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公开(公告)号:US08609617B2
公开(公告)日:2013-12-17
申请号:US13394068
申请日:2010-09-07
CPC分类号: C12N5/0619 , C07K14/4702 , C12N2501/60
摘要: This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 9,12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e.g., KLF 6 and/or 7).
摘要翻译: 本发明涉及一种促进CNS轴突再生的方法,包括:(1)抑制抑制轴突生长的Krüppel样转录因子(KLF)家族中的一个或多个成员的神经元中的表达或活性(例如, KLF 1,2,3,4,5,9,12,13,14,15和/或16),和/或(2)刺激KLF中一个或多个成员的神经元中的表达或活性 促进轴突生长的家庭(例如,KLF 6和/或7)。
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公开(公告)号:US06210369B1
公开(公告)日:2001-04-03
申请号:US09212570
申请日:1998-12-16
申请人: John G. Wilmot , Jeffrey L. Goldberg , Jon Page , Cliff Ketcham , Jeffrey P. Castleberry , Jason Morton , Dave Edsall , Robert R. Boyd , Robert L. Hill
发明人: John G. Wilmot , Jeffrey L. Goldberg , Jon Page , Cliff Ketcham , Jeffrey P. Castleberry , Jason Morton , Dave Edsall , Robert R. Boyd , Robert L. Hill
IPC分类号: A61M520
CPC分类号: A61M5/24 , A61M5/2033 , A61M5/3135 , A61M5/3202 , A61M5/3232 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/2407 , A61M2005/247 , A61M2005/2492 , A61M2005/3118
摘要: The present invention relates to an automatic injector having a drive assembly with an actuator extending from the rearward end portion of the housing and a removal resistant cover for preventing unintended operation of the actuator. The present invention also relates to a sealing arrangement wherein the needle is sealed within a sterilized needle chamber by at least three sealing members which cooperate to form the chamber. Also, the present invention relates to an injector in which the cartridge is mounted to a tubular cartridge mounting portion of the needle carrier with an annular sealing member disposed therebetween. The cartridge mounting portion has at least one generally axially extending groove which allows air to escape from the cartridge mounting portion as the cartridge is being moved forwardly to a medicament supplying position.
摘要翻译: 本发明涉及一种具有驱动组件的自动喷射器,该驱动组件具有从壳体的后端部分延伸的致动器和用于防止致动器意外操作的防拆盖。 本发明还涉及一种密封装置,其中针通过至少三个密封构件密封在灭菌的针室内,这些密封构件协作形成腔室。 此外,本发明涉及一种注射器,其中药筒安装到针架的管状药筒安装部分,其间设置有环形密封件。 盒安装部分具有至少一个大致轴向延伸的凹槽,当槽被向前移动到药物供应位置时,允许空气从盒安装部分逸出。
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公开(公告)号:US09078932B2
公开(公告)日:2015-07-14
申请号:US12866004
申请日:2009-02-04
申请人: Jeffrey L. Goldberg , Alan Halpern
发明人: Jeffrey L. Goldberg , Alan Halpern
IPC分类号: A61K47/48 , A61N2/00 , A61K9/50 , A61K35/12 , A61K35/44 , A61K41/00 , C12N5/00 , A61K9/00 , A61K9/51
CPC分类号: A61K47/6929 , A61K9/0034 , A61K9/0048 , A61K9/5094 , A61K9/5115 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/44 , A61K41/00 , A61K47/68 , A61K47/6803 , A61K47/6829 , A61K47/6901 , A61K47/6923 , A61K47/6931 , A61N2/002 , C12N5/0006
摘要: Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and or injury.
摘要翻译: 具有与其表面结合(固定)的磁性纳米颗粒的正常或遗传修饰的细胞和递送至靶组织的方法,例如, 用于治疗疾病和/或损伤。
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公开(公告)号:US08317861B2
公开(公告)日:2012-11-27
申请号:US11093351
申请日:2005-03-29
IPC分类号: A61F2/20
CPC分类号: A61F2/203 , A61L27/54 , A61L2300/404 , A61L2300/606
摘要: A voice prosthesis comprising a tubular body portion, a valve and a valve seat disposed within the body portion. The valve seat is further comprised of a medical grade elastomer containing a dispersion of an antimicrobial agent. This valve seat extends the life of the prosthesis by retarding the growth of microorganisms. The body portion of the prosthesis may also contain an antimicrobial agent at a concentration that is non-toxic to the tissue it contacts.
摘要翻译: 一种声音假体,包括管状主体部分,阀和设置在主体部分内的阀座。 阀座还包含含有抗微生物剂分散体的医用级弹性体。 该阀座通过延缓微生物的生长来延长假体的寿命。 假体的身体部分还可以含有与其接触的组织无毒的浓度的抗微生物剂。
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5.
公开(公告)号:US20120225084A1
公开(公告)日:2012-09-06
申请号:US13394068
申请日:2010-09-07
IPC分类号: A61K48/00 , A61P25/00 , A61K39/395 , C12Q1/68 , C12N5/0793 , A61K38/02
CPC分类号: C12N5/0619 , C07K14/4702 , C12N2501/60
摘要: This invention relates, e.g., to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 9, 12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e.g., KLF 6 and/or 7).
摘要翻译: 本发明涉及例如促进CNS轴突再生的方法,其包括:(1)抑制抑制轴突生长的Krüppel样转录因子(KLF)家族中一个或多个成员的神经元中的表达或活性( 例如,KLF 1,2,3,4,5,9,12,13,14,15和/或16),和/或(2)刺激一个或多个成员的神经元中的表达或活性 促进轴突生长的KLF家族(例如,KLF 6和/或7)。
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公开(公告)号:US20110003003A1
公开(公告)日:2011-01-06
申请号:US12866004
申请日:2009-02-04
申请人: Jeffrey L. Goldberg , Alan Halpern
发明人: Jeffrey L. Goldberg , Alan Halpern
CPC分类号: A61K47/6929 , A61K9/0034 , A61K9/0048 , A61K9/5094 , A61K9/5115 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/44 , A61K41/00 , A61K47/68 , A61K47/6803 , A61K47/6829 , A61K47/6901 , A61K47/6923 , A61K47/6931 , A61N2/002 , C12N5/0006
摘要: Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and or injury.
摘要翻译: 具有与其表面结合(固定)的磁性纳米颗粒的正常或遗传修饰的细胞和递送至靶组织的方法,例如, 用于治疗疾病和/或损伤。
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