公开(公告)号：US20130266665A1

公开(公告)日：2013-10-10

申请号：US13802080

申请日：2013-03-13

申请人： Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

发明人： Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

IPC分类号： G01N33/50

CPC分类号： G01N33/5044 ,  G01N2800/52 ,  G01Q60/366

摘要： A method of treating a patient having cancer includes: (1) providing a biological sample from the patient, the biological sample including multiple cells; (2) detecting a response of the biological sample to a probing element; (3) based on the response, determining test values for the biological sample, the test values being indicative of a nanomechanical characteristic of the cells; (4) deriving a test nanomechanical profile characterizing a distribution of the test values; and (5) based on the test nanomechanical profile, selecting a therapeutic agent to treat the patient.

摘要翻译： 治疗患有癌症的患者的方法包括：（1）从患者提供生物样品，所述生物样品包括多个细胞; （2）检测生物样品对探测元件的响应; （3）基于响应，确定生物样品的测试值，测试值表示细胞的纳米机械特征; （4）导出表征测试值分布的测试纳米机械轮廓; 和（5）基于测试纳米机械特征，选择治疗剂治疗患者。

公开(公告)号：US20110070604A1

公开(公告)日：2011-03-24

申请号：US12993826

申请日：2008-12-01

申请人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

发明人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

IPC分类号： C12Q1/02 ,  C12M1/34 ,  B82Y15/00 ,  B82Y5/00

CPC分类号： G01Q30/025 ,  B82Y15/00 ,  B82Y35/00 ,  G01Q20/00 ,  G01Q30/14 ,  G01Q60/366 ,  Y10S977/92

摘要： Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.

摘要翻译： 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。

公开(公告)号：US08652798B2

公开(公告)日：2014-02-18

申请号：US12993826

申请日：2008-12-01

申请人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

发明人： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

IPC分类号： C12Q1/02 ,  B82B3/00

CPC分类号： G01Q30/025 ,  B82Y15/00 ,  B82Y35/00 ,  G01Q20/00 ,  G01Q30/14 ,  G01Q60/366 ,  Y10S977/92

摘要： Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.

摘要翻译： 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。

公开(公告)号：US20170231499A1

公开(公告)日：2017-08-17

申请号：US15503371

申请日：2015-08-10

申请人： James K. GIMZEWSKI ,  Shivani SHARMA ,  Paul WILKINSON ,  Nagesh RAGAVENDRA ,  JianYu RAO ,  M. Dayan J. WICKRAMARATNE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： James K. Gimzewski ,  Shivani Sharma ,  Paul R. Wilkinson ,  Nagesh Ragavendra ,  JianYu Rao ,  M. Dayan J. Wickramaratne

IPC分类号： A61B5/00 ,  A61B10/00 ,  A61B10/02 ,  A61B5/06

CPC分类号： A61B5/0048 ,  A61B5/0053 ,  A61B5/062 ,  A61B5/067 ,  A61B5/4312 ,  A61B5/6848 ,  A61B5/7242 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283

摘要： In one aspect, an elastography system includes an elastography device and a position sensing device connected to the elastography device. The elastography device includes a housing, a probing element removably attached to the housing, and a force sensor attached within the housing, where the force sensor is connected to the probing element. In another aspect, an elastography) method includes inserting a probing element into a material, producing, by a force sensor connected to a base of the probing element a signal indicative of a force applied to the probing element upon insertion of the probing element into the material, and based on the signal, deriving a mapping of spatial variations of a material property within the material.