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公开(公告)号：US09216256B2
公开(公告)日：2015-12-22
申请号：US12905572
申请日：2010-10-15
申请人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
发明人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译： 公开了用于胃肠外递送药物例如药物的装置。 该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。
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公开(公告)号：US20110092915A1
公开(公告)日：2011-04-21
申请号：US12905572
申请日：2010-10-15
申请人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
发明人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译： 公开了用于胃肠外递送药物例如药物的装置。 该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。
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公开(公告)号：US20160089503A1
公开(公告)日：2016-03-31
申请号：US14959701
申请日：2015-12-04
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
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4.发明申请2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF 失效2-甲基-5-取代的亚甲基环戊酮衍生物及其用途公开(公告)号：US20110060054A1
公开(公告)日：2011-03-10
申请号：US12867223
申请日：2009-02-10
申请人： Linxiang Zhao , Jingli Wang , Zhenjun Bian , Rui Wang , Dan Liu , Yongkui Jing
发明人： Linxiang Zhao , Jingli Wang , Zhenjun Bian , Rui Wang , Dan Liu , Yongkui Jing
IPC分类号： A61K31/122 , C07C49/647 , C07C317/24 , C07C49/743 , C07C49/683 , C07C49/697 , C07C49/753 , A61P35/00
CPC分类号： C07C49/683 , C07C45/59 , C07C45/673 , C07C49/697 , C07C49/753 , C07C225/22 , C07C317/24 , C07C2601/08 , C07D317/64
摘要： The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
摘要翻译： 本发明涉及式I的2-亚甲基-5-取代 - 亚甲基环戊酮衍生物及其用途。 作为活性组分的式I的衍生物可用于制备用于治疗和/或预防癌症疾病如乳腺癌，肺癌，结肠癌，直肠癌，胃癌，前列腺癌，膀胱癌，子宫癌， 胰腺癌和卵巢癌。 本发明的活性化合物可单独用作抗癌药物或与一种或多种其它抗肿瘤药物组合使用。 联合治疗可以通过同时，随后或分开地施用每种治疗成分进行。
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公开(公告)号：US20070119451A1
公开(公告)日：2007-05-31
申请号：US11606244
申请日：2006-11-29
申请人： Jingli Wang , Johanna Bentz , Rolfe Anderson
发明人： Jingli Wang , Johanna Bentz , Rolfe Anderson
CPC分类号： A61M15/08 , A61M11/008 , A61M15/0028 , A61M15/0033 , A61M2016/0024 , A61M2205/073 , A61M2205/075 , A61M2210/0618
摘要： A device for delivery of a substance to the olfactory region is described. The device includes a nosepiece and an elongate tubular member slidably disposed within the nosepiece for movement between a retracted position and an extended position. The tubular member is in flow communication with a reservoir containing the substance to be delivered. During use, the tubular member extends from the device, to direct the substance toward the olfactory region.
摘要翻译： 描述了将物质输送到嗅觉区域的装置。 该装置包括鼻梁和可滑动地设置在鼻梁内的细长管状构件，用于在缩回位置和延伸位置之间移动。 管状构件与容纳待输送物质的容器流动连通。 在使用期间，管状构件从装置延伸，以将物质引向嗅觉区域。
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公开(公告)号：US09233213B2
公开(公告)日：2016-01-12
申请号：US13833978
申请日：2013-03-15
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
摘要翻译： 构造成施用药物的装置可以包括下壳体，其包括壳体闩锁。 该装置还可以包括针护罩，所述针护罩可沿第一方向相对于所述下壳体从第一位置运动到第二位置，以便露出针头，以及相对于所述下壳体支撑的上壳体。 上壳体可以被构造成沿着从预先使用位置到分配位置的第二方向相对于下壳体移动。 当上壳体处于使用前位置时，壳体闩锁可以可释放地干扰上壳体，以防止上壳体向分配位置移动，并且针护罩朝向第二位置的运动引起干扰 从而允许上壳体朝向第二位置移动。
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公开(公告)号：US20130204229A1
公开(公告)日：2013-08-08
申请号：US13833978
申请日：2013-03-15
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
摘要翻译： 构造成施用药物的装置可以包括下壳体，其包括壳体闩锁。 该装置还可以包括针护罩，所述针护罩可沿第一方向相对于所述下壳体从第一位置运动到第二位置，以便露出针头，以及相对于所述下壳体支撑的上壳体。 上壳体可以被构造成沿着从预先使用位置到分配位置的第二方向相对于下壳体移动。 当上壳体处于使用前位置时，壳体闩锁可以可释放地干扰上壳体，以防止上壳体向分配位置移动，并且针护罩朝向第二位置的运动引起干扰 从而允许上壳体朝向第二位置移动。
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8.发明授权2-methylene-5-substituted-methylenecyclopentanone derivatives and use thereof 失效2-亚甲基-5-取代的亚甲基环戊酮衍生物及其用途公开(公告)号：US08415505B2
公开(公告)日：2013-04-09
申请号：US12867223
申请日：2009-02-10
申请人： Linxiang Zhao , Jingli Wang , Zhenjun Bian , Rui Wang , Dan Liu , Yongkui Jing
发明人： Linxiang Zhao , Jingli Wang , Zhenjun Bian , Rui Wang , Dan Liu , Yongkui Jing
IPC分类号： C07C49/00 , C07C317/24 , A61K31/122
CPC分类号： C07C49/683 , C07C45/59 , C07C45/673 , C07C49/697 , C07C49/753 , C07C225/22 , C07C317/24 , C07C2601/08 , C07D317/64
摘要： The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
摘要翻译： 本发明涉及式I的2-亚甲基-5-取代 - 亚甲基环戊酮衍生物及其用途。 作为活性组分的式I的衍生物可用于制备用于治疗和/或预防癌症疾病如乳腺癌，肺癌，结肠癌，直肠癌，胃癌，前列腺癌，膀胱癌，子宫癌， 胰腺癌和卵巢癌。 本发明的活性化合物可单独用作抗癌药物或与一种或多种其它抗肿瘤药物组合使用。 联合治疗可以通过同时，随后或分开地施用每种治疗成分进行。
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9.发明授权Electro-polishing fixture and electrolyte solution for polishing stents and method 有权用于抛光支架的电抛光夹具和电解质溶液及方法公开(公告)号：US06375826B1
公开(公告)日：2002-04-23
申请号：US09503280
申请日：2000-02-14
IPC分类号： C25F316
摘要： An electro-polishing fixture for polishing stents which incorporates multiple anodes in contact with the stent and a center cathode disposed coaxially within the interior of the stent and a curved exterior cathode disposed about the perimeter of the stent. The invention further includes an electrolyte solution adapted for polishing stents composed of nickel-titanium alloy and a method of using the electrolyte in combination with the electro-polishing fixture.
摘要翻译： 一种用于抛光支架的电抛光夹具，其包括与支架接触的多个阳极和同轴地布置在支架内部的中心阴极和围绕支架周边布置的弯曲外部阴极。 本发明还包括适用于抛光由镍 - 钛合金构成的支架的电解质溶液以及与电抛光固定装置组合使用电解质的方法。
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