公开(公告)号：USRE39606E1

公开(公告)日：2007-05-01

申请号：US10841422

申请日：2004-05-07

申请人： John Cargill

发明人： John Cargill

IPC分类号： G01N33/543 ,  G01N33/544

CPC分类号： G01N33/553 ,  B01J19/0046 ,  B01J2219/00281 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00463 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00504 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00567 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07B43/06 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  G01N33/532 ,  G01N33/54373 ,  G01N33/552

摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

公开(公告)号：US06417010B1

公开(公告)日：2002-07-09

申请号：US09261718

申请日：1999-03-03

申请人： John Cargill ,  Robert W. Armstrong

发明人： John Cargill ,  Robert W. Armstrong

IPC分类号： G01N33543

CPC分类号： G01N33/553 ,  B01J19/0046 ,  B01J2219/00281 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00463 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00504 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00567 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07B43/06 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  G01N33/532 ,  G01N33/54373 ,  G01N33/552

摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

摘要翻译： 本发明提供了随机低聚物的标记的合成文库以及用于产生标记的合成低聚物文库的方法和装置。 这种图书馆的每个成员都标有一个唯一的标识符标签，用于指定低聚物的结构或序列。 在本发明的一个优选实施例中，标识符标签是一种微芯片，其在标识符标签被电磁辐射脉冲时被预先编码或可编码与信号相关的信息。

公开(公告)号：US5770455A

公开(公告)日：1998-06-23

申请号：US480438

申请日：1995-06-07

申请人： John Cargill ,  Robert W. Armstrong

发明人： John Cargill ,  Robert W. Armstrong

IPC分类号： C07D203/12 ,  A61K31/215 ,  A61K38/00 ,  A61P25/02 ,  A61P35/00 ,  B01J19/00 ,  C07B43/06 ,  C07B61/00 ,  C07C279/02 ,  C07D205/08 ,  C07D233/72 ,  C07D303/46 ,  C07D405/12 ,  C07H21/00 ,  C07K1/04 ,  C07K5/103 ,  C07K5/117 ,  C07K7/06 ,  C08B37/00 ,  C08F8/30 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  G01N33/53 ,  G01N33/532 ,  G01N33/543 ,  G01N33/552 ,  G01N33/553 ,  G01N33/544

CPC分类号： G01N33/553 ,  B01J19/0046 ,  C07B43/06 ,  C07K1/047 ,  G01N33/532 ,  G01N33/54373 ,  G01N33/552 ,  B01J2219/00281 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00463 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00504 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00567 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00

摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

摘要翻译： 本发明提供了随机低聚物的标记的合成文库以及用于产生标记的合成低聚物文库的方法和装置。 这种图书馆的每个成员都标有一个唯一的标识符标签，用于指定低聚物的结构或序列。 在本发明的一个优选实施例中，标识符标签是一种微芯片，其在标识符标签被电磁辐射脉冲时被预先编码或可编码与信号相关的信息。

公开(公告)号：US08532952B2

公开(公告)日：2013-09-10

申请号：US12818437

申请日：2010-06-18

申请人： Joseph Pecina ,  Scott Ryan ,  John Cargill

发明人： Joseph Pecina ,  Scott Ryan ,  John Cargill

IPC分类号： G01N17/00 ,  G01N33/20

CPC分类号： G01N17/00 ,  G01N17/02 ,  G01N21/93 ,  G01N29/30 ,  G01N2223/303 ,  G01N2223/3037 ,  G01N2223/6466 ,  Y10T436/10 ,  Y10T436/109163

摘要： Methods and apparatuses are provided for creation of discrete corrosion defects with a wide range of diameter to depth aspect ratios for painted test standards. Also provided are methods for use of those test standards to characterize the corrosion under paint detection threshold, statistical reliability, and accuracy of NDI and/or NDT techniques including but not limited to flash thermography, ultrasonic testing, eddy current testing, microwave testing, shearography, and infrared testing.

摘要翻译： 提供的方法和设备用于创建具有广泛范围的直径与深度纵横比的分离腐蚀缺陷，用于涂漆测试标准。 还提供了使用这些测试标准来表征油漆检测阈值，统计可靠性和NDI和/或NDT技术的精度的腐蚀的方法，包括但不限于闪蒸热成像，超声波测试，涡流测试，微波测试，剪切 ，和红外线测试。

公开(公告)号：US08448490B2

公开(公告)日：2013-05-28

申请号：US12818444

申请日：2010-06-18

申请人： Joseph Pecina ,  Scott Ryan ,  John Cargill

发明人： Joseph Pecina ,  Scott Ryan ,  John Cargill

IPC分类号： G01N17/00 ,  G01N21/93 ,  G01N29/30

CPC分类号： G01N17/00 ,  G01N17/02 ,  G01N21/93 ,  G01N29/30 ,  G01N2223/303 ,  G01N2223/3037 ,  G01N2223/6466 ,  Y10T436/10 ,  Y10T436/109163

摘要： Methods and apparatuses are provided for creation of discrete corrosion defects with a wide range of diameter to depth aspect ratios for painted test standards. Also provided are methods for use of those test standards to characterize the corrosion under paint detection threshold, statistical reliability, and accuracy of NDI and/or NDT techniques including but not limited to flash thermography, ultrasonic testing, eddy current testing, microwave testing, shearography, and infrared testing.

公开(公告)号：US20070220946A1

公开(公告)日：2007-09-27

申请号：US11713886

申请日：2007-03-05

申请人： Joseph Pecina ,  Scott Ryan ,  John Cargill ,  Paul Galbraith ,  Wayne Powell

发明人： Joseph Pecina ,  Scott Ryan ,  John Cargill ,  Paul Galbraith ,  Wayne Powell

IPC分类号： G01N17/00 ,  G01N29/30 ,  G01N33/20 ,  G01N33/00

CPC分类号： G01N17/00 ,  G01N17/02 ,  G01N21/93 ,  G01N29/30 ,  G01N2223/303 ,  G01N2223/3037 ,  G01N2223/6466 ,  Y10T436/10 ,  Y10T436/109163

摘要： Methods and apparatuses are provided for creation of discrete corrosion defects with a wide range of diameter to depth aspect ratios for painted test standards. Also provided are methods for use of those test standards to characterize the corrosion under paint detection threshold, statistical reliability, and accuracy of NDI and/or NDT techniques including but not limited to flash thermography, ultrasonic testing, eddy current testing, microwave testing, shearography, and infrared testing.

摘要翻译： 提供的方法和设备用于创建具有广泛范围的直径与深度纵横比的分离腐蚀缺陷，用于涂漆测试标准。 还提供了使用这些测试标准来表征油漆检测阈值，统计可靠性和NDI和/或NDT技术的精度的腐蚀的方法，包括但不限于闪蒸热成像，超声波测试，涡流测试，微波测试，剪切 ，和红外线测试。

公开(公告)号：US5609826A

公开(公告)日：1997-03-11

申请号：US422869

申请日：1995-04-17

申请人： John Cargill ,  Romaine R. Maiefski

发明人： John Cargill ,  Romaine R. Maiefski

IPC分类号： C12N15/09 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C12M1/00 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/02 ,  B01L11/00

CPC分类号： C07H21/00 ,  B01J19/0046 ,  C07K1/045 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/028

摘要： Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks. An inert atmosphere in the reaction block is maintained by a top and (optional) bottom seal. A synthesis support may be introduced into each reaction chamber as a slurry, and the top septum fastened. A needle pipettes reagents from an array of reagent containers into the reaction chambers, and maintains the inert atmosphere. A locking reagent container rack keeps the containers securely in place.

摘要翻译： 描述了用于生成化学文库的方法和装置。 优选的实施方案包括使用支撑在块中的可更换反应室的反应块。 每个反应块配有四组12个反应室，并具有便于机器人操作的配件。 反应室优选配有玻璃料。 一个S形的收集管卡入每个反应室底部的一个配件。 捕集管进入排水管。 反应块配有气体（优选N2）管线和隔膜密封件，使得气体加压将反应室排空到排放管中。 排水管布置成与标准的96孔微量滴定板直接配合以收集材料。 对接站提供反应块的安全注册，并提供气体和液体引入反应块。 反应块中的惰性气氛通过顶部和（可选）底部密封件保持。 可以将合成载体作为浆料引入每个反应室，并将顶部隔片固定。 针将试剂从试剂容器阵列移入反应室，并保持惰性气氛。 锁定试剂容器架将容器牢固地保持在适当位置。

公开(公告)号：USRE39571E1

公开(公告)日：2007-04-17

申请号：US10841421

申请日：2004-05-07

申请人： John Cargill

发明人： John Cargill

IPC分类号： G01N33/543 ,  C12Q1/68 ,  G08B13/14 ,  A61K38/00

摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

摘要翻译： 本发明提供了随机低聚物的标记的合成文库以及用于产生标记的合成低聚物文库的方法和装置。 这种图书馆的每个成员都标有一个唯一的标识符标签，用于指定低聚物的结构或序列。 在本发明的一个优选实施例中，标识符标签是一种微芯片，其在标识符标签被电磁辐射脉冲时被预先编码或可编码与信号相关的信息。

公开(公告)号：USRE39545E1

公开(公告)日：2007-04-03

申请号：US10841423

申请日：2004-05-07

申请人： John Cargill

发明人： John Cargill

IPC分类号： G01N33/543 ,  C12Q1/68 ,  G08B13/14 ,  A61K38/00

摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

公开(公告)号：US5770157A

公开(公告)日：1998-06-23

申请号：US718105

申请日：1996-09-18

申请人： John Cargill ,  Romaine R. Maiefski

发明人： John Cargill ,  Romaine R. Maiefski

IPC分类号： C12N15/09 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C12M1/00 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/02 ,  B01L3/00

CPC分类号： C07H21/00 ,  B01J19/0046 ,  C07K1/045 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/028

摘要： Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks. An inert atmosphere in the reaction block is maintained by a top and (optional) bottom seal. A synthesis support may be introduced into each reaction chamber as a slurry, and the top septum fastened. A needle pipettes reagents from an array of reagent containers into the reaction chambers, and maintains the inert atmosphere. A locking reagent container rack keeps the containers securely in place.

摘要翻译： 描述了用于生成化学文库的方法和装置。 优选的实施方案包括使用支撑在块中的可更换反应室的反应块。 每个反应块配有四组12个反应室，并具有便于机器人操作的配件。 反应室优选配有玻璃料。 一个S形的收集管卡入每个反应室底部的一个配件。 捕集管进入排水管。 反应块配有气体（优选N2）管线和隔膜密封件，使得气体加压将反应室排空到排放管中。 排水管布置成与标准的96孔微量滴定板直接配合以收集材料。 对接站提供反应块的安全注册，并提供气体和液体引入反应块。 反应块中的惰性气氛通过顶部和（可选）底部密封件保持。 可以将合成载体作为浆料引入每个反应室，并将顶部隔片固定。 针将试剂从试剂容器阵列移入反应室，并保持惰性气氛。 锁定试剂容器架将容器牢固地保持在适当位置。