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1.发明申请公开(公告)号：US20110319742A1
公开(公告)日：2011-12-29
申请号：US12877738
申请日：2010-09-08
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/150022 , A61B5/150175 , A61B5/150389 , A61B5/150419 , A61B5/150427 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150755 , A61B5/15117 , A61B5/15121 , A61B5/15123 , A61B5/15151 , A61B5/15163 , A61B5/157 , A61B5/685 , A61B2562/046 , A61M2037/0061
摘要： A method for monitoring at least one biomedical characteristic is disclosed. A first microneedle coated with one or more regions of a chemical sensing material is illuminated. One or more digital images are captured of the first microneedle, wherein at least one of the one or more digital images is captured after the first coated microneedle has been actuated to penetrate a subject's skin. Pixel information is spatially extracted from the captured one or more images to define one or more pixel sample areas corresponding to the one or more regions of a chemical sensing material. One or more spectral characteristics are determined for each of the one or more pixel sample areas. The at least one biomedical characteristic is determined for each of the one or more pixel sample areas based on the determined one or more spectral characteristics for each of the one or more pixel sample areas.
摘要翻译： 公开了一种用于监测至少一种生物医学特性的方法。 涂覆有化学感测材料的一个或多个区域的第一微针被照亮。 捕获第一微针的一个或多个数字图像，其中在第一涂覆的微针被致动以穿透受试者的皮肤之后，捕获一个或多个数字图像中的至少一个。 从所捕获的一个或多个图像中空间地提取像素信息以定义与化学感测材料的一个或多个区域相对应的一个或多个像素样本区域。 确定一个或多个像素样本区域中的每一个的一个或多个光谱特性。 基于所确定的一个或多个像素样本区域中的每个像素样本区域的一个或多个光谱特性，为一个或多个像素采样区域中的每一个确定至少一个生物医学特征。
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公开(公告)号：US20100100005A1
公开(公告)日：2010-04-22
申请号：US12373385
申请日：2007-02-05
申请人： Jose Mir , Dennis Roland Zander
发明人： Jose Mir , Dennis Roland Zander
IPC分类号： A61B5/00
摘要： An allergy testing system has a microneedle array. The allergy testing system also has at least one coated allergen. The allergy testing system further has an activation system coupled to the microneedle array such that the at least one coated allergen is moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is disclosed. One or more allergen coated microneedles is caused to penetrate into a skin of the patient. One or more images of at least one of the penetrations into the skin are captured. At least one of the captured images are analyzed to assess the degree of reaction to a specific allergen. Allergic reactivity data is output for at least one of the allergens.
摘要翻译： 过敏测试系统具有微针阵列。 过敏测试系统还具有至少一种包衣过敏原。 过敏测试系统还具有耦合到微针阵列的激活系统，使得当微针阵列从静止位置移动到穿透位置时，使至少一个被涂覆的变应原移动到与受试者接触。 公开了以微创方式确定患者对一种或多种变应原的反应程度的方法。 使一种或多种过敏原包被的微针穿透到患者的皮肤中。 捕获至少一个穿入皮肤的一个或多个图像。 分析至少一个捕获的图像以评估对特定变应原的反应程度。 对至少一种过敏原输出过敏反应性数据。
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公开(公告)号：US20080269635A1
公开(公告)日：2008-10-30
申请号：US11995366
申请日：2006-07-11
申请人： Jose Mir , Dennis Roland Zander
发明人： Jose Mir , Dennis Roland Zander
CPC分类号： A61B5/0059 , A61B5/411 , A61B5/444 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： An allergy testing system includes encapsulated allergens, a microneedle array, and an activation system coupled to the microneedle array and the encapsulated allergens such that the encapsulated allergens are moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is also disclosed. Penetration of one or more microneedles into a skin of the patient is caused. Each of the penetrations into the skin is exposed with an allergen from each of the one or more microneedles. One or more images are captured of each of the penetrations into the skin. Each of the captured images are analyzed to assess the degree of reaction to the specific allergen. Allergic reactivity data is output for at least one of the allergens.
摘要翻译： 过敏测试系统包括包封的过敏原，微针阵列和耦合到微针阵列和包封的变应原的激活系统，使得当微针阵列从静止位置移动到穿透时，包封的过敏原被移动到与受试者接触 位置。 还公开了以微创方式确定患者对一种或多种过敏原的反应程度的方法。 引起一个或多个微针穿入患者皮肤。 穿过皮肤的每一个都被来自一个或多个微针中的每一个的变应原暴露。 将每个穿透物捕获到皮肤中的一个或多个图像。 分析每个捕获的图像以评估对特定变应原的反应程度。 对至少一种过敏原输出过敏反应性数据。
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4.发明申请System and method for obtaining image-based products from a digital motion picture source 有权用于从数字电影源获得基于图像的产品的系统和方法公开(公告)号：US20060147179A1
公开(公告)日：2006-07-06
申请号：US11016008
申请日：2004-12-17
申请人： Rajiv Mehrotra , Jose Mir
发明人： Rajiv Mehrotra , Jose Mir
CPC分类号： H04N7/17318 , G06Q30/06 , G11B27/32 , H04N1/00132 , H04N1/00143 , H04N1/00188 , H04N1/0019 , H04N1/00198 , H04N1/00283 , H04N1/00297 , H04N21/2542 , H04N21/42646 , H04N21/4333 , H04N21/472 , H04N21/47815 , H04N21/6581 , H04N21/8153 , H04N21/835 , H04N21/8455
摘要： Image-based products are obtained from a digital motion picture source by utilizing a content playing and display system for (a) displaying a sequence of motion picture image frames from a digital motion picture image source containing motion picture contents, and (b) selecting one or more of the image frames for an image-based product and obtaining a unique frame identification for said one or more selected frames; a content management system that (a) utilizes the unique frame identification and determines whether at least one permissible image-based product can be made from said one or more selected frames, and (b), if a permissible image-based product may be made as determined, obtains file data corresponding to said one or more selected frames from a digital source file containg source information corresponding to the motion picture contents; an order management system for preparing order information for the permissible image-based product from the file data; and an order fulfillment system for generating the image-based product from the file data according to the order information.
摘要翻译： 基于图像的产品通过利用内容播放和显示系统从数字运动图像源获得，用于（a）从包含运动图像内容的数字运动图像图像源显示运动图像帧序列，以及（b）选择一个 或更多的用于基于图像的产品的图像帧，并且获得用于所述一个或多个所选帧的唯一帧标识; 一种内容管理系统，其（a）利用唯一的帧识别，并确定是否可以从所述一个或多个所选择的帧中进行至少一个许可的基于图像的产品，以及（b）如果可以制作允许的基于图像的产品 从包含与运动图像内容相对应的源信息的数字源文件中获得与所述一个或多个所选帧对应的文件数据; 订单管理系统，用于从所述文件数据准备所述允许的基于图像的商品的订单信息; 以及用于根据订单信息从文件数据生成基于图像的产品的订单履行系统。
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公开(公告)号：US20120253224A1
公开(公告)日：2012-10-04
申请号：US13272966
申请日：2011-10-13
申请人： Jose Mir , John Spoonhower , John A. Agostinelli , John Squilla
发明人： Jose Mir , John Spoonhower , John A. Agostinelli , John Squilla
IPC分类号： A61B5/00
CPC分类号： A61B5/441 , A61B5/0053 , A61B5/0077 , A61B5/442
摘要： An apparatus and method for making an apparatus for skin testing includes a housing with an opening which defines a field of view of a skin testing region, an image sensing apparatus, an illumination apparatus, a binding apparatus, and an image processing controller. The image sensing apparatus is positioned with respect to the housing to capture images in the field of view provided by the opening. The illumination apparatus is positioned within the housing to direct light towards a portion of the field of view provided by the opening. The binding apparatus detachably secures the housing over the skin testing region and maintains a fixed distance between the image sensing apparatus and the skin testing region. The controller is configured to analyze test samples sites in each of the captured images from the image sensing apparatus and provide a skin test result for each of the test sample sites.
摘要翻译： 用于制造皮肤测试装置的装置和方法包括具有限定皮肤测试区域的视野的开口的壳体，图像感测装置，照明装置，装订装置和图像处理控制器。 图像感测装置相对于壳体定位以捕获由开口提供的视野中的图像。 照明装置位于壳体内以将光引导到由开口提供的视场的一部分。 装订装置将外壳可拆卸地固定在皮肤测试区域上，并且在图像感测装置和皮肤测试区域之间保持固定的距离。 控制器被配置为分析来自图像感测装置的每个捕获图像中的测试样本位置，并为每个测试样本位置提供皮肤测试结果。
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公开(公告)号：US20090093697A1
公开(公告)日：2009-04-09
申请号：US12189509
申请日：2008-08-11
IPC分类号： A61B5/145
CPC分类号： A61B5/02035
摘要： A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum.
摘要翻译： 公开了一种确定凝血酶原时间的方法。 将介体应用于角质层。 穿透角质层以允许介体进入含有组织液的区域并与至少一个毛细管相互作用，导致血液和/或血液成分从至少一个毛细管渗漏到含有间质液的区域中。 在与凝血酶原时间相关的含有间质液的区域中测量受血液和/或血液成分影响的特征。 还公开了一种用于测量凝血酶原时间的系统。 该系统具有介体，一个或多个微针，以及处理器，其直接或间接地耦合到所述一个或多个微针并且被配置为确定在所述一个或多个微针之后的所述一个或多个微针周围的区域中的血液或血液成分中的凝血变化 微针穿透角质层。
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公开(公告)号：US20080218696A1
公开(公告)日：2008-09-11
申请号：US11994444
申请日：2006-06-30
申请人： Jose Mir
发明人： Jose Mir
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A monitoring system includes a light source that illuminates at least a portion of a subject's eye with an incident light beam, and a contact lens with a coupler. The coupler couples the incident light beam into an aqueous humor of the eye, creating an aqueous light beam. The coupler also couples the aqueous light beam out of the aqueous humor of the eye, creating an output light beam. The monitoring system also includes a sensor that measures at least one spectral characteristic of the output light beam. The monitoring system further includes a processing system that determines at least one measurable characteristic of the subject based on the at least one spectral characteristic of the output light beam. A method for monitoring is provided, as well as a contact lens for use with a monitoring systems, and a method of manufacturing a contact lens.
摘要翻译： 监视系统包括用入射光束照射被检者眼睛的至少一部分的光源和具有耦合器的隐形眼镜。 耦合器将入射光束耦合到眼睛的房水中，产生水性光束。 耦合器还将水光束耦合到眼睛的房水中，产生输出光束。 监测系统还包括测量输出光束的至少一个光谱特性的传感器。 监测系统还包括处理系统，其基于输出光束的至少一个光谱特性确定对象的至少一个可测量特征。 提供了一种用于监视的方法，以及用于监视系统的隐形眼镜以及制造隐形眼镜的方法。
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公开(公告)号：US20110224515A1
公开(公告)日：2011-09-15
申请号：US12877755
申请日：2010-09-08
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/150022 , A61B5/150175 , A61B5/150389 , A61B5/150419 , A61B5/150427 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150755 , A61B5/15117 , A61B5/15121 , A61B5/15123 , A61B5/15151 , A61B5/15163 , A61B5/157 , A61B5/685 , A61B2562/046 , A61M2037/0061
摘要： A replaceable microneedle array for a biomedical monitor is disclosed. The microneedle array includes a plurality of moveable microneedles coated with at least one chemical sensing material coupled with a porous material. The microneedle array also includes a substrate defining wells to house the microneedles. The microneedle array further includes at least one restoring spring element coupled between each microneedle and the substrate such that each of the plurality of microneedles is held at least partially in an associated well.
摘要翻译： 公开了用于生物医学监视器的可替换的微针阵列。 微针阵列包括多个可移动的微针，其涂覆有与多孔材料耦合的至少一种化学感测材料。 微针阵列还包括限定用于容纳微针的孔的衬底。 微针阵列还包括耦合在每个微针和基板之间的至少一个恢复弹簧元件，使得多个微针中的每一个至少部分保持在相关联的孔中。
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公开(公告)号：US07942827B2
公开(公告)日：2011-05-17
申请号：US11995366
申请日：2006-07-11
申请人： Jose Mir , Dennis Roland Zander
发明人： Jose Mir , Dennis Roland Zander
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/411 , A61B5/444 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： An allergy testing system includes encapsulated allergens, a microneedle array, and an activation system coupled to the microneedle array and the encapsulated allergens such that the encapsulated allergens are moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is also disclosed. Penetration of one or more microneedles into a skin of the patient is caused. Each of the penetrations into the skin is exposed with an allergen from each of the one or more microneedles. One or more images are captured of each of the penetrations into the skin. Each of the captured images are analyzed to assess the degree of reaction to the specific allergen. Allergic reactivity data is output for at least one of the allergens.
摘要翻译： 过敏测试系统包括包封的过敏原，微针阵列和耦合到微针阵列和包封的变应原的激活系统，使得当微针阵列从静止位置移动到穿透时，包封的过敏原被移动到与受试者接触 位置。 还公开了以微创方式确定患者对一种或多种过敏原的反应程度的方法。 引起一个或多个微针穿入患者皮肤。 穿过皮肤的每一个都被来自一个或多个微针中的每一个的变应原暴露。 将每个穿透物捕获到皮肤中的一个或多个图像。 分析每个捕获的图像以评估对特定变应原的反应程度。 对至少一种过敏原输出过敏反应性数据。
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公开(公告)号：US20090295910A1
公开(公告)日：2009-12-03
申请号：US11912361
申请日：2006-03-24
申请人： Jose Mir , Dennis Zander
发明人： Jose Mir , Dennis Zander
IPC分类号： H04N7/18
CPC分类号： G01J3/2823 , G01J3/02 , G01J3/0208 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0278 , G01J3/0291 , G01J3/0294 , G01J3/10 , G01N21/31 , G01N2021/3133 , G01N2021/317 , G01N2201/0221
摘要： A hyperspectral imaging system and methods thereof especially useful in fields such as medicine, food safety, chemical sensing, and agriculture, for example. In one embodiment, the hyperspectral imaging module contains a light source (1) for illuminating the object (6) in a light-tight housing (17). The light is spectrally filtered (4) prior to illuminating the object. The light leaving the object is then directed through imaging optics (T) to an imaging array (9). In another embodiment, the object of interest is illuminated by ambient light which is then compensated by a light modulation system. In this embodiment, the light emitted from the object is spectrally filtered prior to reaching the imaging array.
摘要翻译： 一种高光谱成像系统及其方法在医药，食品安全，化学感应和农业等领域尤其有用。 在一个实施例中，高光谱成像模块包含用于在无光外壳（17）中照亮物体（6）的光源（1）。 在照射物体之前，光线被光谱过滤（4）。 离开物体的光然后被引导通过成像光学元件（T）到成像阵列（9）。 在另一个实施例中，感兴趣的对象被环境光照亮，然后光被光调制系统补偿。 在该实施例中，在到达成像阵列之前，从对象发射的光被光谱滤波。
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