公开(公告)号：US20090295910A1

公开(公告)日：2009-12-03

申请号：US11912361

申请日：2006-03-24

申请人： Jose Mir ,  Dennis Zander

发明人： Jose Mir ,  Dennis Zander

IPC分类号： H04N7/18

CPC分类号： G01J3/2823 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01N21/31 ,  G01N2021/3133 ,  G01N2021/317 ,  G01N2201/0221

摘要： A hyperspectral imaging system and methods thereof especially useful in fields such as medicine, food safety, chemical sensing, and agriculture, for example. In one embodiment, the hyperspectral imaging module contains a light source (1) for illuminating the object (6) in a light-tight housing (17). The light is spectrally filtered (4) prior to illuminating the object. The light leaving the object is then directed through imaging optics (T) to an imaging array (9). In another embodiment, the object of interest is illuminated by ambient light which is then compensated by a light modulation system. In this embodiment, the light emitted from the object is spectrally filtered prior to reaching the imaging array.

摘要翻译： 一种高光谱成像系统及其方法在医药，食品安全，化学感应和农业等领域尤其有用。 在一个实施例中，高光谱成像模块包含用于在无光外壳（17）中照亮物体（6）的光源（1）。 在照射物体之前，光线被光谱过滤（4）。 离开物体的光然后被引导通过成像光学元件（T）到成像阵列（9）。 在另一个实施例中，感兴趣的对象被环境光照亮，然后光被光调制系统补偿。 在该实施例中，在到达成像阵列之前，从对象发射的光被光谱滤波。

公开(公告)号：US20060264715A1

公开(公告)日：2006-11-23

申请号：US11279290

申请日：2006-04-11

申请人： Jose Mir ,  Dennis Zander

发明人： Jose Mir ,  Dennis Zander

IPC分类号： A61B5/00

CPC分类号： A61B5/14503 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150282 ,  A61B5/150984 ,  A61B5/685 ,  A61B2560/0412

摘要： A blood monitoring system is capable of monitoring the blood of a subject in vivo. The blood monitoring system comprises: 1) an array of movable microneedle micromachined within associated wells; 2) array of motion actuators able to move each needle in and out of their associated wells; 3) array of microvalves associated with each microneedle able to control the flow of air around the microneedle; 4) an array of chemical sensors inserted into patient by movable microneedles; 5) an array of inductors able to measure chemical concentration in the vicinity of inserted chemical sensors; 6) conducting vias that provide timed actuating signal signals from a control system to each motion actuator; 7) conducting vias that transmit signal produced by array of chemical sensors to the control system for processing, although the blood monitoring system can comprise other numbers and types of elements in other configurations.

摘要翻译： 血液监测系统能够在体内监测受试者的血液。 血液监测系统包括：1）在相关井内微加工的可移动微针阵列; 2）运动致动器阵列，能够将每个针头移入和移出其相关联的井; 3）与每个微针相关联的微阀阵列，能够控制微针周围空气的流动; 4）可移动微针插入病人的化学传感器阵列; 5）能够测量插入的化学传感器附近的化学浓度的电感器阵列; 6）进行通孔，其提供从控制系统到每个运动致动器的定时致动信号信号; 7）将通过化学传感器阵列产生的信号传导到控制系统进行处理的通孔，尽管血液监测系统可以包括其它配置中的其它数量和类型的元件。

公开(公告)号：US08108023B2

公开(公告)日：2012-01-31

申请号：US11279290

申请日：2006-04-11

申请人： Jose Mir ,  Dennis Zander

发明人： Jose Mir ,  Dennis Zander

IPC分类号： A61B5/05

CPC分类号： A61B5/14503 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150282 ,  A61B5/150984 ,  A61B5/685 ,  A61B2560/0412

摘要： A blood monitoring system is capable of monitoring the blood of a subject in vivo. The blood monitoring system comprises: 1) an array of movable microneedle micromachined within associated wells; 2) array of motion actuators able to move each needle in and out of their associated wells; 3) array of microvalves associated with each microneedle able to control the flow of air around the microneedle; 4) an array of chemical sensors inserted into patient by movable microneedles; 5) an array of inductors able to measure chemical concentration in the vicinity of inserted chemical sensors; 6) conducting vias that provide timed actuating signal signals from a control system to each motion actuator; 7) conducting vias that transmit signal produced by array of chemical sensors to the control system for processing, although the blood monitoring system can comprise other numbers and types of elements in other configurations.

摘要翻译： 血液监测系统能够在体内监测受试者的血液。 血液监测系统包括：1）在相关井内微加工的可移动微针阵列; 2）运动致动器阵列，能够将每个针头移入和移出其相关联的井; 3）与每个微针相关联的微阀阵列，能够控制微针周围空气的流动; 4）可移动微针插入病人的化学传感器阵列; 5）能够测量插入的化学传感器附近的化学浓度的电感器阵列; 6）进行通孔，其提供从控制系统到每个运动致动器的定时致动信号信号; 7）将通过化学传感器阵列产生的信号的通孔传导到控制系统进行处理，尽管血液监测系统可以包括其它配置中的其它数量和类型的元件。

公开(公告)号：US20120253224A1

公开(公告)日：2012-10-04

申请号：US13272966

申请日：2011-10-13

申请人： Jose Mir ,  John Spoonhower ,  John A. Agostinelli ,  John Squilla

发明人： Jose Mir ,  John Spoonhower ,  John A. Agostinelli ,  John Squilla

IPC分类号： A61B5/00

CPC分类号： A61B5/441 ,  A61B5/0053 ,  A61B5/0077 ,  A61B5/442

摘要： An apparatus and method for making an apparatus for skin testing includes a housing with an opening which defines a field of view of a skin testing region, an image sensing apparatus, an illumination apparatus, a binding apparatus, and an image processing controller. The image sensing apparatus is positioned with respect to the housing to capture images in the field of view provided by the opening. The illumination apparatus is positioned within the housing to direct light towards a portion of the field of view provided by the opening. The binding apparatus detachably secures the housing over the skin testing region and maintains a fixed distance between the image sensing apparatus and the skin testing region. The controller is configured to analyze test samples sites in each of the captured images from the image sensing apparatus and provide a skin test result for each of the test sample sites.

摘要翻译： 用于制造皮肤测试装置的装置和方法包括具有限定皮肤测试区域的视野的开口的壳体，图像感测装置，照明装置，装订装置和图像处理控制器。 图像感测装置相对于壳体定位以捕获由开口提供的视野中的图像。 照明装置位于壳体内以将光引导到由开口提供的视场的一部分。 装订装置将外壳可拆卸地固定在皮肤测试区域上，并且在图像感测装置和皮肤测试区域之间保持固定的距离。 控制器被配置为分析来自图像感测装置的每个捕获图像中的测试样本位置，并为每个测试样本位置提供皮肤测试结果。

公开(公告)号：US20080218696A1

公开(公告)日：2008-09-11

申请号：US11994444

申请日：2006-06-30

申请人： Jose Mir

发明人： Jose Mir

IPC分类号： A61B3/10 ,  G02C7/04

CPC分类号： A61B5/1455 ,  A61B5/14532

摘要： A monitoring system includes a light source that illuminates at least a portion of a subject's eye with an incident light beam, and a contact lens with a coupler. The coupler couples the incident light beam into an aqueous humor of the eye, creating an aqueous light beam. The coupler also couples the aqueous light beam out of the aqueous humor of the eye, creating an output light beam. The monitoring system also includes a sensor that measures at least one spectral characteristic of the output light beam. The monitoring system further includes a processing system that determines at least one measurable characteristic of the subject based on the at least one spectral characteristic of the output light beam. A method for monitoring is provided, as well as a contact lens for use with a monitoring systems, and a method of manufacturing a contact lens.

摘要翻译： 监视系统包括用入射光束照射被检者眼睛的至少一部分的光源和具有耦合器的隐形眼镜。 耦合器将入射光束耦合到眼睛的房水中，产生水性光束。 耦合器还将水光束耦合到眼睛的房水中，产生输出光束。 监测系统还包括测量输出光束的至少一个光谱特性的传感器。 监测系统还包括处理系统，其基于输出光束的至少一个光谱特性确定对象的至少一个可测量特征。 提供了一种用于监视的方法，以及用于监视系统的隐形眼镜以及制造隐形眼镜的方法。

公开(公告)号：US20080214952A1

公开(公告)日：2008-09-04

申请号：US11995370

申请日：2006-07-11

申请人： Jose Mir ,  Dennis Roland Zander

发明人： Jose Mir ,  Dennis Roland Zander

IPC分类号： A61M37/00 ,  A61B5/00 ,  B65B43/00

CPC分类号： A61B5/0059 ,  A61B5/411 ,  A61B5/444 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A replaceable cartridge for use in a minimally invasive allergy testing system includes a microneedle array; encapsulated allergens, and packaging to hold the array in alignment with the allergens. A method of manufacturing a replaceable cartridge is disclosed. A formable layer is placed on a mold having cavities and vacuum lines coupled to the cavities. Heat is applied to the formable layer and a negative pressure is applied to the vacuum lines to wrap the cavities with the formable layer. The wrapped cavities are filled with allergens. The filled cavities are covered with a plastic cover to form an encapsulated allergen assembly. A removable seal is applied over the plastic cover. A microneedle array having a substrate and at least one microneedle is formed. An energy storage device is coupled to the substrate to form a microneedle array assembly. The encapsulated allergen assembly is coupled with the microneedle array assembly.

摘要翻译： 用于微创过敏测试系统的可更换盒包括微针阵列; 包封的过敏原和包装以将阵列保持与过敏原保持一致。 公开了一种制造可更换盒的方法。 将可成形层放置在具有耦合到空腔的空腔和真空管线的模具上。 将热量施加到可成形层上，并将负压施加到真空管线以将空腔与可成形层包裹。 包裹的空腔充满了过敏原。 填充的空腔被塑料盖覆盖以形成封装的变应原组件。 在塑料盖上涂上可拆卸的密封。 形成具有基底和至少一个微针的微针阵列。 能量存储装置耦合到衬底以形成微针阵列组件。 包封的变应原组件与微针阵列组件耦合。

公开(公告)号：US20070276211A1

公开(公告)日：2007-11-29

申请号：US11754987

申请日：2007-05-29

申请人： Jose Mir ,  James Lee

发明人： Jose Mir ,  James Lee

IPC分类号： A61M31/00 ,  A61B5/05

CPC分类号： A61B5/685 ,  A61B5/0075 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486

摘要： A biomedical monitor is disclosed. The biomedical monitor has an array of moveable microneedles coated with a first chemical sensing media. The biomedical monitor also has an actuator configured to move at least one microneedle in the array of microneedles from a retracted position to an engaged position whereby the at least one microneedle enters a subject's skin. The biomedical monitor further has an optical system configured to illuminate the at least one microneedle during or after entering the subject's skin and monitor the first chemical sensing media from the at least one microneedle, whereby at least one biomedical characteristic is determined based on at least one spectral property of the monitored first chemical sensing media. A method of monitoring at least one biomedical characteristic is also disclosed.

摘要翻译： 公开了一种生物医学监测器。 生物医学监视器具有涂覆有第一化学感测介质的可移动微针阵列。 生物医学监视器还具有致动器，该致动器被配置为将微针阵列中的至少一个微针从缩回位置移动到接合位置，由此至少一个微针进入受试者的皮肤。 该生物医学监视器还具有一种光学系统，其被配置为在进入对象的皮肤期间或之后照亮该至少一个微针，并且从该至少一个微针监测第一化学感测介质，由此至少一个生物医学特征基于至少一个 监测的第一化学传感介质的光谱性质。 还公开了一种监测至少一种生物医学特性的方法。

公开(公告)号：US20110319742A1

公开(公告)日：2011-12-29

申请号：US12877738

申请日：2010-09-08

申请人： Jose Mir ,  John Spoonhower ,  John A. Agostinelli ,  Larry Demejo ,  Kamal K. Sarbadhikari

发明人： Jose Mir ,  John Spoonhower ,  John A. Agostinelli ,  Larry Demejo ,  Kamal K. Sarbadhikari

IPC分类号： A61B5/00

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150389 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150755 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/157 ,  A61B5/685 ,  A61B2562/046 ,  A61M2037/0061

摘要： A method for monitoring at least one biomedical characteristic is disclosed. A first microneedle coated with one or more regions of a chemical sensing material is illuminated. One or more digital images are captured of the first microneedle, wherein at least one of the one or more digital images is captured after the first coated microneedle has been actuated to penetrate a subject's skin. Pixel information is spatially extracted from the captured one or more images to define one or more pixel sample areas corresponding to the one or more regions of a chemical sensing material. One or more spectral characteristics are determined for each of the one or more pixel sample areas. The at least one biomedical characteristic is determined for each of the one or more pixel sample areas based on the determined one or more spectral characteristics for each of the one or more pixel sample areas.

摘要翻译： 公开了一种用于监测至少一种生物医学特性的方法。 涂覆有化学感测材料的一个或多个区域的第一微针被照亮。 捕获第一微针的一个或多个数字图像，其中在第一涂覆的微针被致动以穿透受试者的皮肤之后，捕获一个或多个数字图像中的至少一个。 从所捕获的一个或多个图像中空间地提取像素信息以定义与化学感测材料的一个或多个区域相对应的一个或多个像素样本区域。 确定一个或多个像素样本区域中的每一个的一个或多个光谱特性。 基于所确定的一个或多个像素样本区域中的每个像素样本区域的一个或多个光谱特性，为一个或多个像素采样区域中的每一个确定至少一个生物医学特征。

公开(公告)号：US20100100005A1

公开(公告)日：2010-04-22

申请号：US12373385

申请日：2007-02-05

申请人： Jose Mir ,  Dennis Roland Zander

发明人： Jose Mir ,  Dennis Roland Zander

IPC分类号： A61B5/00

CPC分类号： A61B5/411 ,  A61B5/685

摘要： An allergy testing system has a microneedle array. The allergy testing system also has at least one coated allergen. The allergy testing system further has an activation system coupled to the microneedle array such that the at least one coated allergen is moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is disclosed. One or more allergen coated microneedles is caused to penetrate into a skin of the patient. One or more images of at least one of the penetrations into the skin are captured. At least one of the captured images are analyzed to assess the degree of reaction to a specific allergen. Allergic reactivity data is output for at least one of the allergens.

摘要翻译： 过敏测试系统具有微针阵列。 过敏测试系统还具有至少一种包衣过敏原。 过敏测试系统还具有耦合到微针阵列的激活系统，使得当微针阵列从静止位置移动到穿透位置时，使至少一个被涂覆的变应原移动到与受试者接触。 公开了以微创方式确定患者对一种或多种变应原的反应程度的方法。 使一种或多种过敏原包被的微针穿透到患者的皮肤中。 捕获至少一个穿入皮肤的一个或多个图像。 分析至少一个捕获的图像以评估对特定变应原的反应程度。 对至少一种过敏原输出过敏反应性数据。

公开(公告)号：US20080269635A1

公开(公告)日：2008-10-30

申请号：US11995366

申请日：2006-07-11

申请人： Jose Mir ,  Dennis Roland Zander

发明人： Jose Mir ,  Dennis Roland Zander

IPC分类号： A61B5/00 ,  G06K9/00

CPC分类号： A61B5/0059 ,  A61B5/411 ,  A61B5/444 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An allergy testing system includes encapsulated allergens, a microneedle array, and an activation system coupled to the microneedle array and the encapsulated allergens such that the encapsulated allergens are moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is also disclosed. Penetration of one or more microneedles into a skin of the patient is caused. Each of the penetrations into the skin is exposed with an allergen from each of the one or more microneedles. One or more images are captured of each of the penetrations into the skin. Each of the captured images are analyzed to assess the degree of reaction to the specific allergen. Allergic reactivity data is output for at least one of the allergens.

摘要翻译： 过敏测试系统包括包封的过敏原，微针阵列和耦合到微针阵列和包封的变应原的激活系统，使得当微针阵列从静止位置移动到穿透时，包封的过敏原被移动到与受试者接触 位置。 还公开了以微创方式确定患者对一种或多种过敏原的反应程度的方法。 引起一个或多个微针穿入患者皮肤。 穿过皮肤的每一个都被来自一个或多个微针中的每一个的变应原暴露。 将每个穿透物捕获到皮肤中的一个或多个图像。 分析每个捕获的图像以评估对特定变应原的反应程度。 对至少一种过敏原输出过敏反应性数据。