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    Adenoviral vector with replication-dependent transgene expression
    5.
    发明申请
    Adenoviral vector with replication-dependent transgene expression 有权
    具有复制依赖性转基因表达的腺病毒载体

    公开(公告)号：US20050063953A1

    公开(公告)日：2005-03-24

    申请号：US10911957

    申请日：2004-08-05

    申请人： Erik Falck-Pedersen ,  Jason Gall

    发明人： Erik Falck-Pedersen ,  Jason Gall

    IPC分类号： A61K48/00 ,  C12N15/861

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2840/44

    摘要： The invention provides an adenoviral vector comprising (a) at least a portion of an adenoviral genome comprising a major late transcription unit containing a terminal exon, wherein the terminal exon comprises a 5′ splice acceptor DNA sequence element and a 3′ polyadenylation signal sequence, and (b) a non-native nucleic acid sequence encoding a protein that does not contribute to the adenoviral vector entry into a host cell, wherein the non-native nucleic acid sequence is positioned within the terminal exon, such that the non-native nucleic acid sequence is selectively expressed in cells within which the adenoviral vector can replicate. The invention further provides an adenoviral vector composition and a method for treating or preventing a pathologic state in a mammal, comprising administering to the mammal the adenoviral vector composition of the invention in an amount sufficient to treat or prevent the pathologic state in the mammal.

    摘要翻译： 本发明提供了一种腺病毒载体，其包含（a）至少一部分腺病毒基因组，其包含含有末端外显子的主要晚期转录单位，其中所述末端外显子包含5'剪接受体DNA序列元件和3'多腺苷酸化信号序列， 和（b）编码不对腺病毒载体进入宿主细胞有贡献的蛋白质的非天然核酸序列，其中非天然核酸序列位于末端外显子内，使得非天然核酸 酸序列在腺病毒载体可以复制的细胞中选择性表达。 本发明进一步提供了一种用于治疗或预防哺乳动物病理状态的腺病毒载体组合物和方法，其包括以足以治疗或预防哺乳动物病理状态的量向哺乳动物施用本发明的腺病毒载体组合物。

    Adenoviral vector-based vaccines
    8.
    发明申请
    Adenoviral vector-based vaccines 审中-公开
    基于腺病毒载体的疫苗

    公开(公告)号：US20060286121A1

    公开(公告)日：2006-12-21

    申请号：US11337866

    申请日：2006-01-23

    申请人： Jason Gall ,  Thomas Wickham ,  William Enright ,  Douglas Brough ,  Mohammed Zuber ,  C. King ,  Gary Nabel ,  Cheng Cheng

    发明人： Jason Gall ,  Thomas Wickham ,  William Enright ,  Douglas Brough ,  Mohammed Zuber ,  C. King ,  Gary Nabel ,  Cheng Cheng

    IPC分类号： A61K39/12 ,  A61K39/395

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345

    摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80% or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

    摘要翻译： 本发明提供在哺乳动物中诱导免疫应答的方法。 该方法包括向哺乳动物施用非亚组C腺病毒载体，其包含具有与编码亚组C腺病毒纤维蛋白的氨基酸序列具有约80％或更高同一性的氨基酸序列的腺病毒纤维蛋白。 腺病毒载体还包含编码在哺乳动物中表达以诱导免疫应答的抗原的核酸序列。 本发明还包括产生腺病毒载体的方法和包含血清型41或血清型35腺病毒载体和载体的组合物。 本发明还提供了一种腺病毒载体，其包含编码与异源表达控制序列可操作地连接的腺病毒pIX蛋白的核酸序列，以及增强腺病毒载体的稳定性和/或包装能力的方法。

    METHOD OF USING ADENOVIRAL VECTORS WITH INCREASED IMMUNOGENICITY IN VIVO
    9.
    发明申请
    METHOD OF USING ADENOVIRAL VECTORS WITH INCREASED IMMUNOGENICITY IN VIVO 审中-公开
    使用腺病毒载体在体内具有增加的免疫原性的方法

    公开(公告)号：US20080069836A1

    公开(公告)日：2008-03-20

    申请号：US11678947

    申请日：2007-02-26

    申请人： Gary Nabel ,  Cheng Cheng ,  Jason Gall ,  Thomas Wickham

    发明人： Gary Nabel ,  Cheng Cheng ,  Jason Gall ,  Thomas Wickham

    IPC分类号： A61K39/00 ,  A61P37/04 ,  C12N15/63

    CPC分类号： C12N15/86 ,  A61K39/00 ,  C12N2710/10343 ,  Y02A50/412

    摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.

    摘要翻译： 本发明提供在哺乳动物中诱导免疫应答的方法。 该方法包括向哺乳动物施用腺病毒载体，其包含（a）亚组C纤维蛋白，其中天然柯萨奇病毒和腺病毒受体（CAR）结合位点被破坏，（b）亚基C戊聚糖碱基蛋白，其中天然整联蛋白结合 位点被破坏，和（c）编码至少一种来源于哺乳动物中表达的腺病毒以外的感染因子的抗原以诱导免疫应答的核酸序列。