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公开(公告)号：US08985429B2
公开(公告)日：2015-03-24
申请号：US13242164
申请日：2011-09-23
申请人： Stephen J. Balek , Chad P. Boudreaux , Matthew D. Holcomb , Thomas W. Lytle, IV , Matthew C. Miller , Charles J. Scheib , Bret W. Smith , Yi-Lan Wang , Donald F. Wilson, Jr. , Edward A. Rhad , Kreena R. Modi , Joseph Zavatsky , Aron O. Zingman
发明人： Stephen J. Balek , Chad P. Boudreaux , Matthew D. Holcomb , Thomas W. Lytle, IV , Matthew C. Miller , Charles J. Scheib , Bret W. Smith , Yi-Lan Wang , Donald F. Wilson, Jr. , Edward A. Rhad , Kreena R. Modi , Joseph Zavatsky , Aron O. Zingman
IPC分类号： A61B17/068 , A61B17/00 , A61B17/072 , A61B17/32
CPC分类号： A61B17/00491 , A61B17/07207 , A61B2017/07271 , A61B2017/07285 , A61B2017/320052
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a removable cartridge. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further includes an agent. The firing bar is operable to assist with releasing the agent onto a severed line of tissue when the firing bar is advanced.
摘要翻译： 手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切割组件。 下颌构造成接收可移除的盒。 盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。 甲板限定孔，每个孔基本上设置在每个钉上。 该盒还包括一个代理。 射击杆可操作以帮助当射击杆前进时将药剂释放到组织切断线上。
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2.发明授权公开(公告)号：US08138236B2
公开(公告)日：2012-03-20
申请号：US12608361
申请日：2009-10-29
CPC分类号： A61L24/0094 , A61L24/043 , C08L71/02 , C08L79/00
摘要： The invention relates to a novel moisture activated solvent-free latent curing adhesive or sealant mixture comprising (1) a selected poly(alkylene oxide)imine, and (2) a selected amine reactive moiety.
摘要翻译： 本发明涉及一种新型水分活化无溶剂的潜在固化粘合剂或密封剂混合物，其包含（1）选择的聚（环氧烷）亚胺和（2）选择的胺反应性部分。
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公开(公告)号：US08969649B2
公开(公告)日：2015-03-03
申请号：US13571770
申请日：2012-08-10
CPC分类号： A61F13/00063 , A61F13/00068 , A61F13/023 , A61F2013/00412 , A61M2025/0266
摘要： A device for the dressing of wounds and insertion sites of percutaneous and drug delivery devices provides 360 degree or complete circumferential protection of a wound or insertion site of a percutaneous or drug delivery device. In particular, the device is an integrated dressing for catheters comprising a pad and an adhesive dressing.
摘要翻译： 用于修整经皮和药物递送装置的伤口和插入部位的装置为经皮或药物递送装置的伤口或插入部位提供360度或完全圆周保护。 特别地，该装置是用于导管的综合敷料，其包括垫和粘合剂敷料。
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公开(公告)号：US20120288530A1
公开(公告)日：2012-11-15
申请号：US13107375
申请日：2011-05-13
CPC分类号： A61L24/106
摘要： The present invention is directed in one embodiment to a tissue adhesive or sealant composition comprising an electrophilic group containing cross-linking compound having a linker moiety of a diglycolic acid, a water soluble core moiety and an electrophilic group that is covalently bonded to the diglycolic acid linker moiety and a nucleophilic group containing protein. In other embodiments, the present invention is directed to a delivery device or a medical device on which the composition has been applied or incorporated therein. The present invention is also directed to a method for sealing tissue using the tissue adhesive or sealant composition.
摘要翻译： 本发明在一个实施方案中涉及一种组织粘合剂或密封剂组合物，其包含亲电子基团，该亲电子基团含有交联化合物，该交联化合物具有二甘醇酸的接头部分，水溶性核心部分和与二甘醇酸共价结合的亲电子基团 接头部分和含亲核基团的蛋白质。 在其它实施方案中，本发明涉及其上已经施用或并入其中的组合物的递送装置或医疗装置。 本发明还涉及使用组织粘合剂或密封剂组合物密封组织的方法。
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公开(公告)号：US07947758B2
公开(公告)日：2011-05-24
申请号：US11501541
申请日：2006-08-09
IPC分类号： C09J139/00 , C09J133/14 , A61L27/14
CPC分类号： C09J179/02 , A61L24/046 , C08G18/10 , C08G18/503 , C08G65/325 , C08G65/326 , C08G65/3324 , C08G2190/00 , C08L79/02 , C09J175/04 , C08L71/02 , C08G18/48
摘要： The invention relates to a novel poly(ethylene oxide)imine; a novel amine reactive moiety; a novel moisture activated latent curing adhesive or sealant mixture comprising (1) a ketimine or aldimine, and (2) an amine reactive moiety; and a novel moisture activated latent curing adhesive or sealant comprising the reaction product of (1) and (2).
摘要翻译： 本发明涉及新型聚（环氧乙烷）亚胺; 一种新的胺反应性部分; 一种新型水分活化的潜在固化粘合剂或密封剂混合物，其包含（1）酮亚胺或醛亚胺，和（2）胺反应性部分; 和包含（1）和（2）的反应产物的新型水分活化的潜在固化粘合剂或密封剂。
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公开(公告)号：US20080039547A1
公开(公告)日：2008-02-14
申请号：US11501541
申请日：2006-08-09
IPC分类号： A61K6/083
CPC分类号： C09J179/02 , A61L24/046 , C08G18/10 , C08G18/503 , C08G65/325 , C08G65/326 , C08G65/3324 , C08G2190/00 , C08L79/02 , C09J175/04 , C08L71/02 , C08G18/48
摘要： The invention relates to a novel poly(ethylene oxide)imine; a novel amine reactive moiety; a novel moisture activated latent curing adhesive or sealant mixture comprising (1) a ketimine or aldimine, and (2) an amine reactive moiety; and a novel moisture activated latent curing adhesive or sealant comprising the reaction product of (1) and (2).
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公开(公告)号：US09492170B2
公开(公告)日：2016-11-15
申请号：US13206752
申请日：2011-08-10
申请人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
发明人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
IPC分类号： A61B17/04 , A61B17/10 , A61B17/072 , A61B17/00 , A61B17/29
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00495 , A61B2017/00893 , A61B2017/07271 , A61B2017/2927
摘要： A modular end effector delivers a therapeutic agent onto tissue that has been severed and/or stapled. The end effector is removably attached to a device. The device applies force to a piston of the end effector. The force causes a distal movement of a piston along a wall disposed within the end effector. The piston engages with agents stored on opposite sides of the wall, moving the agents distally to a mixture space. The agents are mixed in the mixture space and expelled through a tip. Staples may be embedded in or disposed below a foam block, which is disposed within a staple cartridge. Via an endoscopic stapling device, coated staples are driven through tissue while interacting with another agent on the device or the cartridge. The interaction forms a tissue restoring material that is applied onto the tissue.
摘要翻译： 模块化的末端执行器将治疗剂递送到已被切断和/或装订的组织上。 端部执行器可拆卸地连接到装置。 该装置对末端执行器的活塞施加力。 该力导致活塞沿着设置在末端执行器内的壁的远端移动。 活塞与存储在壁的相对侧上的试剂接合，将试剂向远端移动到混合物空间。 将试剂在混合物空间中混合并通过尖端排出。 钉书钉可以嵌入或设置在布置在钉仓内的泡沫块的下方。 通过内窥镜缝合装置，当与装置或药筒上的另一药剂相互作用时，涂布的钉被驱动通过组织。 相互作用形成施加到组织上的组织恢复材料。
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公开(公告)号：US20140046238A1
公开(公告)日：2014-02-13
申请号：US13571770
申请日：2012-08-10
IPC分类号： A61F13/00
CPC分类号： A61F13/00063 , A61F13/00068 , A61F13/023 , A61F2013/00412 , A61M2025/0266
摘要： The invention relates to a device for the dressing of wounds and insertion sites of percutaneous and drug delivery devices. The device provides 360 degree or complete circumferential protection of a wound or insertion site of a percutaneous or drug delivery device. In particular, the device is an integrated dressing for catheters comprising a pad and an adhesive dressing.
摘要翻译： 本发明涉及用于修整经皮和药物递送装置的伤口和插入部位的装置。 该装置提供经皮或药物递送装置的伤口或插入部位的360度或完全圆周保护。 特别地，该装置是用于导管的综合敷料，其包括垫和粘合剂敷料。
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9.发明申请MEDICALLY ACCEPTABLE FORMULATION OF A DIISOCYANATE TERMINATED MACROMER FOR USE AS AN INTERNAL ADHESIVE OR SEALANT 有权用作内部胶粘剂或密封剂的二异氰酸酯终止的MACROMER的医学上可接受的配方公开(公告)号：US20090222038A1
公开(公告)日：2009-09-03
申请号：US12415155
申请日：2009-03-31
CPC分类号： A61L24/0042 , A61L24/043 , A61L31/041 , A61L31/148 , C08G18/10 , C08G18/42 , C08L75/04
摘要： The present invention is directed to a medically acceptable formulation comprising a diisocyanate terminated macromer or mixture thereof, and bio-absorbable desiccant comprising a hygroscopic and/or hydrophilic or combination thereof. The present invention is also directed to methods of use for such formulations for medical procedures.
摘要翻译： 本发明涉及包含二异氰酸酯封端的大分子单体或其混合物的医学上可接受的制剂，以及包含吸湿性和/或亲水性或其组合的生物可吸收干燥剂。 本发明还涉及用于这种制剂用于医疗过程的方法。
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公开(公告)号：US20080039548A1
公开(公告)日：2008-02-14
申请号：US11501651
申请日：2006-08-09
申请人： Joseph Zavatsky , Binoy K. Bordoloi
发明人： Joseph Zavatsky , Binoy K. Bordoloi
IPC分类号： A61K6/083
CPC分类号： C09J171/02 , A61L24/046 , C08G18/10 , C08G18/503 , C08G65/325 , C08G65/326 , C08G65/331 , C08G65/3324 , C08G65/33337 , C08G2190/00 , C08L79/00 , C08G18/50
摘要： The invention relates to a novel poly(ethylene oxide)imine; a novel amine reactive moiety; a novel moisture activated latent curing adhesive or sealant mixture comprising (1) a ketimine or aldimine, and (2) an amine reactive moiety; and a novel moisture activated latent curing adhesive or sealant comprising the reaction product of (1) and (2).
摘要翻译： 本发明涉及新型聚（环氧乙烷）亚胺; 一种新的胺反应性部分; 一种新型水分活化的潜在固化粘合剂或密封剂混合物，其包含（1）酮亚胺或醛亚胺，和（2）胺反应性部分; 和包含（1）和（2）的反应产物的新型水分活化的潜在固化粘合剂或密封剂。
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