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公开(公告)号：US20130017580A1
公开(公告)日：2013-01-17
申请号：US13514750
申请日：2010-12-08
申请人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
发明人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。
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2.发明申请Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法。公开(公告)号：US20130302859A1
公开(公告)日：2013-11-14
申请号：US13890944
申请日：2013-05-09
申请人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
发明人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
IPC分类号： C12N9/00
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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公开(公告)号：US09598712B2
公开(公告)日：2017-03-21
申请号：US14384233
申请日：2013-03-22
申请人： Michael Crowe , Michael Foulkes , Giancarlo Francese , Dominique Grimler , Ernst Kuesters , Kurt Laumen , Yunzhong Li , Changxue Lin , Jovana Nazor , Thomas Ruch , Derek Smith , Shiwei Song , Shangjun Teng
发明人： Michael Crowe , Michael Foulkes , Giancarlo Francese , Dominique Grimler , Ernst Kuesters , Kurt Laumen , Yunzhong Li , Changxue Lin , Jovana Nazor , Thomas Ruch , Derek Smith , Shiwei Song , Shangjun Teng
IPC分类号： C07D209/12 , C07D209/16 , C12P17/10 , C07D405/06 , C07D471/20 , C07D209/14 , C07D209/34 , C12N9/10 , C07D209/38
CPC分类号： C12P17/10 , C07D209/12 , C07D209/14 , C07D209/34 , C07D209/38 , C07D405/06 , C07D471/20 , C12N9/1096 , Y02P20/52
摘要： The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
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公开(公告)号：US08895271B2
公开(公告)日：2014-11-25
申请号：US13514750
申请日：2010-12-08
申请人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
发明人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。
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5.发明授权Engineered imine reductases and methods for the reductive animation of ketone and amine compounds 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法公开(公告)号：US09193957B2
公开(公告)日：2015-11-24
申请号：US13890944
申请日：2013-05-09
申请人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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