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1.发明申请公开(公告)号：US20140199735A1
公开(公告)日：2014-07-17
申请号：US14110964
申请日：2012-04-12
申请人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
发明人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
摘要翻译： 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。
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2.发明申请Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法。公开(公告)号：US20130302859A1
公开(公告)日：2013-11-14
申请号：US13890944
申请日：2013-05-09
申请人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
发明人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
IPC分类号： C12N9/00
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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3.发明授权Engineered imine reductases and methods for the reductive animation of ketone and amine compounds 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法公开(公告)号：US09193957B2
公开(公告)日：2015-11-24
申请号：US13890944
申请日：2013-05-09
申请人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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4.发明授权Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine 有权用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法公开(公告)号：US08932836B2
公开(公告)日：2015-01-13
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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5.发明授权公开(公告)号：US09102963B2
公开(公告)日：2015-08-11
申请号：US14110964
申请日：2012-04-12
申请人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
发明人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
IPC分类号： C12P17/10 , C12N9/02 , C07D223/22 , C07D223/28 , C07D453/02 , C12P41/00 , C12N9/04
CPC分类号： C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
摘要翻译： 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。
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6.发明授权公开(公告)号：US08354262B2
公开(公告)日：2013-01-15
申请号：US13174253
申请日：2011-06-30
申请人： Scott Novick , Oscar Alvizo
发明人： Scott Novick , Oscar Alvizo
CPC分类号： C12N9/96 , B01D53/1475 , B01D53/1493 , B01D53/84 , B01D2252/20484 , B01D2252/20489 , B01D2252/602 , B01D2255/804 , B01D2257/504 , B01D2258/0283 , C12N9/88 , Y02C10/06 , Y02P20/59
摘要： The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.
摘要翻译： 本公开涉及化学修饰的碳酸酐酶多肽和可溶性组合物，包含它们的均匀液体制剂。 化学修饰的碳酸酐酶多肽相对于不经化学修饰的相同碳酸酐酶多肽具有改进的性质，包括在胺化合物，氨或碳酸根离子存在下增加的活性和/或稳定性的改进性质。 本公开还提供了制备化学修饰的多肽的方法和使用化学修饰的多肽用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳进行进一步处理和/ 或隔离。
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7.发明授权公开(公告)号：US08354261B2
公开(公告)日：2013-01-15
申请号：US13174479
申请日：2011-06-30
申请人： Oscar Alvizo , Mike Benoit , Irene Fusman , Jack Liang , Luan Nguyen , Scott Novick
发明人： Oscar Alvizo , Mike Benoit , Irene Fusman , Jack Liang , Luan Nguyen , Scott Novick
CPC分类号： C12Y402/01001 , C12N9/88
摘要： The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.
摘要翻译： 本公开涉及具有改进性质的碳酸酐酶多肽类，包括在胺化合物，氨或碳酸根离子存在下增加的热稳定性和/或稳定性。 本公开还提供了多肽的制剂和用途，用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳用于进一步处理和/或螯合。 还提供了编码碳酸酐酶多肽和能够表达它们的宿主细胞的多核苷酸。
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8.发明申请BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE 有权（1R，2R）-2-（3,4-二甲氧基苯基）环己基胺的合成的生物化学和方法公开(公告)号：US20130164794A1
公开(公告)日：2013-06-27
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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9.发明授权Highly stable beta-class carbonic anhydrases useful in carbon capture systems 有权用于碳捕集系统的高度稳定的β级碳酸酐酶公开(公告)号：US08420364B2
公开(公告)日：2013-04-16
申请号：US13174393
申请日：2011-06-30
申请人： Oscar Alvizo , Mike Benoit , Scott Novick
发明人： Oscar Alvizo , Mike Benoit , Scott Novick
CPC分类号： C12N9/88 , B01D53/62 , C12Y402/01001
摘要： The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.
摘要翻译： 本公开涉及具有改进性质的碳酸酐酶多肽类，包括在胺化合物，氨或碳酸根离子存在下增加的热稳定性和/或稳定性。 本公开还提供了多肽的制剂和用途，用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳用于进一步处理和/或螯合。 还提供了编码碳酸酐酶多肽和能够表达它们的宿主细胞的多核苷酸。
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10.发明申请公开(公告)号：US20120009646A1
公开(公告)日：2012-01-12
申请号：US13174253
申请日：2011-06-30
申请人： Scott Novick , Oscar Alvizo
发明人： Scott Novick , Oscar Alvizo
CPC分类号： C12N9/96 , B01D53/1475 , B01D53/1493 , B01D53/84 , B01D2252/20484 , B01D2252/20489 , B01D2252/602 , B01D2255/804 , B01D2257/504 , B01D2258/0283 , C12N9/88 , Y02C10/06 , Y02P20/59
摘要： The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.
摘要翻译： 本公开涉及化学修饰的碳酸酐酶多肽和可溶性组合物，包含它们的均匀液体制剂。 化学修饰的碳酸酐酶多肽相对于不经化学修饰的相同碳酸酐酶多肽具有改进的性质，包括在胺化合物，氨或碳酸根离子存在下增加的活性和/或稳定性的改进性质。 本公开还提供了制备化学修饰的多肽的方法和使用化学修饰的多肽用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳进行进一步处理和/ 或隔离。
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