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公开(公告)号：US6046011A
公开(公告)日：2000-04-04
申请号：US105298
申请日：1998-06-26
IPC分类号： C07H21/04 , C07K14/72 , C12N5/06 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/567 , G01N33/74
CPC分类号： G01N33/566 , C07K14/723 , C12Q1/6876 , G01N33/74 , C12Q2600/158 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adreocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH-R agonists and antagonists in vitro using prerations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH-R receptor gene. The invention specifically provides human and bovine ACTH-R genes.
摘要翻译： 本发明涉及哺乳动物促肾上腺皮质激素受体。 本发明涉及哺乳动物促肾上腺皮质激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化真核细胞的培养物中表达哺乳动物促肾上腺皮质激素受体的重组真核表达构建体和转化的真核生物 合成哺乳动物促肾上腺皮质激素受体的细胞。 本发明还提供了使用由包含ACTH-R受体基因的重组真核表达构建体转化的真核细胞的这种培养物的受体的预测体外筛选ACTH-R激动剂和拮抗剂的方法。 本发明特别提供人和牛ACTH-R基因。
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公开(公告)号：US5994087A
公开(公告)日：1999-11-30
申请号：US475637
申请日：1995-06-07
IPC分类号： C07K14/72 , C12N15/12 , G01N33/74 , G01N33/567 , G01N33/48 , G01N33/53 , G01N33/574
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译： 本发明涉及哺乳动物黑皮质素受体。 本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。 本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。 还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。 本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。
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公开(公告)号：US5554729A
公开(公告)日：1996-09-10
申请号：US77673
申请日：1993-06-15
IPC分类号： C07H21/04 , C07K14/72 , C12N5/06 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/567 , G01N33/74 , C07K14/705 , C07K14/71
CPC分类号： G01N33/566 , C07K14/723 , C12Q1/6876 , G01N33/74 , C12Q2600/158 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.
摘要翻译： 本发明涉及哺乳动物促肾上腺皮质激素受体。 本发明涉及哺乳动物促肾上腺皮质激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化的真核细胞和转化真核生物培养物中表达哺乳动物促肾上腺皮质激素受体的重组真核表达构建体 合成哺乳动物促肾上腺皮质激素受体的细胞。 本发明还提供了使用由包含ACTHR受体基因的重组真核表达构建体转化的真核细胞的这种培养物的受体制备体外筛选ACTHR激动剂和拮抗剂的方法。 本发明特别提供人和牛ACTHR基因。
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公开(公告)号：US06268221B1
公开(公告)日：2001-07-31
申请号：US09201746
申请日：1998-12-01
IPC分类号： G01N33566
CPC分类号： G01N33/74 , C07K14/72 , C12Q1/6886 , C12Q2600/136 , G01N2333/726
摘要： The present invention relates to a mammalian melanocyte stimulating hormone receptor (MSH-R). The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocyte stimulating hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian melanocyte stimulating hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian melanocyte stimulating hormone receptor. The invention also provide methods for screening MSH-R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the MSH-R receptor gene. The invention specifically provides human and mouse MSH-R genes.
摘要翻译： 本发明涉及哺乳动物黑素细胞激素受体（MSH-R）。 本发明涉及哺乳动物黑素细胞刺激激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化的真核细胞和这种培养物的培养物中表达哺乳动物黑素细胞刺激激素受体的重组真核表达构建体 的转化真核细胞，合成哺乳动物黑素细胞刺激激素受体。 本发明还提供了使用由包含MSH-R受体基因的重组真核表达构建体转化的真核细胞的这种培养物的受体制备体外筛选MSH-R激动剂和拮抗剂的方法。 本发明特别提供人和小鼠MSH-R基因。
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公开(公告)号：US5837521A
公开(公告)日：1998-11-17
申请号：US44812
申请日：1993-04-08
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译： 本发明涉及哺乳动物黑皮质素受体。 本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。 本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。 还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。 本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。
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公开(公告)号：US06392027B1
公开(公告)日：2002-05-21
申请号：US09542122
申请日：2000-04-04
IPC分类号： C07H2104
CPC分类号： G01N33/566 , C07K14/723 , C12Q1/6876 , C12Q2600/158 , G01N33/74 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTHR agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTHR receptor gene. The invention specifically provides human and bovine ACTHR genes.
摘要翻译： 本发明涉及哺乳动物促肾上腺皮质激素受体。 本发明涉及哺乳动物促肾上腺皮质激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化的真核细胞和转化真核生物培养物中表达哺乳动物促肾上腺皮质激素受体的重组真核表达构建体 合成哺乳动物促肾上腺皮质激素受体的细胞。 本发明还提供了使用由包含ACTHR受体基因的重组真核表达构建体转化的真核细胞的这种培养物的受体制备体外筛选ACTHR激动剂和拮抗剂的方法。 本发明特别提供人和牛ACTHR基因。
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7.发明授权DNA sequence encoding bovine and human adrenocorticotropic hormone receptors 失效编码牛和人促肾上腺皮质激素受体的DNA序列
公开(公告)号：US5280112A
公开(公告)日：1994-01-18
申请号：US866560
申请日：1992-04-10
IPC分类号： C07H21/04 , C07K14/72 , C12N5/06 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/567 , G01N33/74 , C07H15/12 , A61K37/24 , A61K37/38 , C12Q1/00
CPC分类号： G01N33/566 , C07K14/723 , C12Q1/6876 , G01N33/74 , C12Q2600/158 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.
摘要翻译： 本发明涉及哺乳动物促肾上腺皮质激素受体。 本发明涉及哺乳动物促肾上腺皮质激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化的真核细胞和转化真核生物培养物中表达哺乳动物促肾上腺皮质激素受体的重组真核表达构建体 合成哺乳动物促肾上腺皮质激素受体的细胞。 本发明还提供了使用由含有ACTHR受体基因的重组真核表达构建体转化的真核细胞培养物的受体制备体外筛选ACTHR激动剂和拮抗剂的方法。 本发明特别提供人和牛ACTHR基因。
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公开(公告)号：US06261838B1
公开(公告)日：2001-07-17
申请号：US09191359
申请日：1998-11-13
IPC分类号： C07K14705
CPC分类号： G01N33/74 , C07K14/723
摘要： The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
摘要翻译： 本发明涉及哺乳动物黑皮质素受体。 本发明涉及哺乳动物黑皮质素受体（MC3-R）的分离，表征和药理学应用。 本发明特别提供了一种称为MC3-R的特异性黑皮质素受体，其被分离为相应于大鼠该受体基因的mRNA的互补DNA拷贝。 还提供了能够在转化的真核细胞和合成哺乳动物黑皮质素受体的转化真核细胞的这种培养物中表达哺乳动物黑皮质素受体的真核重组表达构建体。 本发明还提供了使用来自用重组表达构建体转化的真核细胞的这种培养物的受体蛋白质的制备物筛选这种黑皮质素受体的体外激动剂和拮抗剂的方法。
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公开(公告)号：US5849871A
公开(公告)日：1998-12-15
申请号：US466906
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K39/395 , C07H21/04 , C07K14/705 , C07K14/72 , C07K16/00 , C07K16/28 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/74 , C07K14/68
CPC分类号： G01N33/74 , C07K14/72 , C12Q1/6886 , C12Q2600/136 , G01N2333/726
摘要： The present invention relates to a mammalian alpha-melanocyte stimulating hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian melanocyte stimulating hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian melanocyte stimulating hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian melanocyte stimulating hormone receptor. The invention also provides methods for screening MSH-R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the MSH-R receptor gene. The invention specifically provides human and mouse MSH-R genes.
摘要翻译： 本发明涉及哺乳动物α-黑素细胞刺激激素受体。 本发明涉及哺乳动物黑素细胞刺激激素受体的分离，表征和药理学应用，该受体是相应于该受体的基因，能够在转化的真核细胞培养物中表达哺乳动物黑素细胞刺激激素受体的重组真核表达构建体， 转化的真核细胞合成哺乳动物黑素细胞刺激激素受体。 本发明还提供了使用由含有MSH-R受体基因的重组真核表达构建体转化的真核细胞培养物的受体制备体外筛选MSH-R激动剂和拮抗剂的方法。 本发明特别提供人和小鼠MSH-R基因。
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公开(公告)号：US5773229A
公开(公告)日：1998-06-30
申请号：US478992
申请日：1995-06-07
IPC分类号： C07H21/04 , C07K14/72 , C12N5/06 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/567 , G01N33/74
CPC分类号： G01N33/566 , C07K14/723 , C12Q1/6876 , G01N33/74 , C12Q2600/158 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.
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