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1.发明授权公开(公告)号：US08065010B2
公开(公告)日：2011-11-22
申请号：US12319642
申请日：2009-01-08
申请人： Marina V. Brockway , Donald L. Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth C. Beck
发明人： Marina V. Brockway , Donald L. Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth C. Beck
IPC分类号： A61N1/36
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果未检测到心源性肺水肿，则基于由可植入或非可行的肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。
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公开(公告)号：US08428711B2
公开(公告)日：2013-04-23
申请号：US12249842
申请日：2008-10-10
申请人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
发明人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译： 描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。 该系统也可用于治疗涉及呼吸驱动障碍的其他病症。
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公开(公告)号：US09730618B2
公开(公告)日：2017-08-15
申请号：US13024720
申请日：2011-02-10
申请人： Kenneth C. Beck , Lemont Baker , Kassity Yefei Liu
发明人： Kenneth C. Beck , Lemont Baker , Kassity Yefei Liu
IPC分类号： A61B5/02 , A61B5/11 , G06F19/00 , A61B5/0245 , A61B5/08
CPC分类号： A61B5/1118 , A61B5/0245 , A61B5/0816 , G06F19/00 , G16H50/50
摘要： A physiological response to activity (PRA) during a subject's activities of daily living (ADL) can be used, such as to generate useful diagnostic information about the subject. This can involve using a template, such as an impulse response template. The technique can be used with an implantable or other ambulatory medical monitoring or therapy device, such as a cardiac function management device, or with a local or remote external interface device.
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公开(公告)号：US08905925B2
公开(公告)日：2014-12-09
申请号：US12482172
申请日：2009-06-10
CPC分类号： A61B5/222 , A61B5/0022 , A61B5/0031 , A61B5/0205 , A61B5/4833 , A61N1/362 , A61N1/37247 , A63B2230/08 , G06F19/00 , G06F19/3418 , G06F19/3475 , G06F19/36 , G16H40/63 , G16H40/67 , G16H80/00 , Y10S482/902
摘要： Systems and methods permit remotely-monitored rehabilitation of a patient. A system can comprise a patient monitor configured to monitor a patient's physiological data. The patient monitor can monitor using a first monitoring mode. A patient communication device can be configured to present, to the patient, an option to perform an exercise regimen, and to receive a response indicating whether the patient will perform the exercise regimen. A configuration module coupled to the patient communication device can be configured to activate a second monitoring mode when the response indicates that the patient will perform the exercise regimen. When the exercise regimen is complete, the first monitoring mode can be re-established. When the response indicates that the patient will not perform the exercise regimen, the response can be recorded as a negative response, and the option to perform the exercise regimen can be presented again.
摘要翻译： 系统和方法允许远程监测患者的康复。 系统可以包括被配置为监视患者生理数据的患者监护仪。 患者监护仪可以使用第一监测模式进行监测。 患者通信装置可以被配置为向患者呈现执行运动方案的选项，并且接收指示患者是否将执行运动方案的响应。 耦合到患者通信设备的配置模块可以被配置为当响应指示患者将执行运动方案时激活第二监视模式。 运动方案完成后，可以重新建立第一种监测模式。 当反应表明患者不能进行运动方案时，可以将反应记录为阴性反应，并且可再次呈现执行运动方案的选择。
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公开(公告)号：US08417463B2
公开(公告)日：2013-04-09
申请号：US12505926
申请日：2009-07-20
CPC分类号： A61B5/03 , A61B5/021 , A61B5/0537 , A61B5/4878
摘要： This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).
摘要翻译： 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。
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公开(公告)号：US20100094102A1
公开(公告)日：2010-04-15
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译： 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。
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公开(公告)号：US20100022911A1
公开(公告)日：2010-01-28
申请号：US12505926
申请日：2009-07-20
IPC分类号： A61B5/00
CPC分类号： A61B5/03 , A61B5/021 , A61B5/0537 , A61B5/4878
摘要： This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).
摘要翻译： 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。
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公开(公告)号：US06363890B1
公开(公告)日：2002-04-02
申请号：US09035655
申请日：1998-03-06
申请人： Kenneth C. Beck
发明人： Kenneth C. Beck
IPC分类号： A01K1015
CPC分类号： A01K1/0157 , A01K1/0107 , A01K1/015
摘要： A package for animal bedding which includes one or more pads or sheets of cotton within a plastic pouch is disclosed. The pads are placed within the pouch and the air from the interior of the pouch is evacuated. The pouch is then sealed. The package is also irradiated in order to provide sterile sheets to be used to line the bottom of animal cages.
摘要翻译： 公开了一种用于动物床上用品的包装，其在塑料袋内包括一个或多个棉布片或片材。 垫被放置在袋内，并且将来自袋内部的空气排出。 然后将小袋密封。 包装也被照射，以提供用于排列动物笼的底部的无菌片。
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公开(公告)号：US09066659B2
公开(公告)日：2015-06-30
申请号：US13437318
申请日：2012-04-02
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/11 , G06F19/00 , A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02405 , A61B5/076 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/4848 , A61B5/686 , A61B5/7246 , A61B5/7275 , A61B5/742 , A61B2560/0462 , A61B2562/0219 , A61N1/36535 , G06F19/34 , G16H20/40
摘要： Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status.
摘要翻译： 可以接收患者姿势信息，例如指示患者姿势的变化至少阈值量。 可以在患者姿势变化附近的多个实例处接收表示生理参数变化的瞬时响应信号。 可以从瞬态响应信号中提取波形形态特征，并用于提供心脏状态的指示，例如心力衰竭状态。
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10.发明授权公开(公告)号：US08321003B2
公开(公告)日：2012-11-27
申请号：US12508398
申请日：2009-07-23
申请人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
发明人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
IPC分类号： A61B5/04
CPC分类号： A61B5/0205 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/4519
摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.
摘要翻译： 本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。
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