公开(公告)号：US5037976A

公开(公告)日：1991-08-06

申请号：US430539

申请日：1989-11-01

Applicant: Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

Inventor： Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined, pharmaceutically acceptable salts thereof, composition containing the same and processes for preparing the same are disclosed. The compound is useful as an antimicrobial agent.

公开(公告)号：US4634783A

公开(公告)日：1987-01-06

申请号：US573268

申请日：1984-01-23

Applicant: Setsuro Fujii ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Ryoji Matsui ,  Shin-ichi Watanabe ,  Kimio Sudo ,  Toshiyuki Okutome ,  Masateru Kurumi ,  Yojiro Sakurai ,  Takuo Aoyama

Inventor： Setsuro Fujii ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Ryoji Matsui ,  Shin-ichi Watanabe ,  Kimio Sudo ,  Toshiyuki Okutome ,  Masateru Kurumi ,  Yojiro Sakurai ,  Takuo Aoyama

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/454 ,  A61K31/455 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61K31/5415 ,  A61P1/00 ,  A61P7/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D207/16 ,  C07D207/337 ,  C07D207/34 ,  C07D209/08 ,  C07D209/18 ,  C07D209/30 ,  C07D209/42 ,  C07D211/62 ,  C07D213/55 ,  C07D213/79 ,  C07D213/80 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D233/54 ,  C07D233/60 ,  C07D233/61 ,  C07D235/06 ,  C07D235/28 ,  C07D235/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D263/42 ,  C07D277/68 ,  C07D279/22 ,  C07D279/36 ,  C07D307/16 ,  C07D307/24 ,  C07D307/54 ,  C07D307/68 ,  C07D307/71 ,  C07D307/85 ,  C07D311/12 ,  C07D333/24 ,  C07D333/38 ,  C07D333/70 ,  C12N9/99 ,  C07D307/56 ,  C07D307/64 ,  C07D307/66

CPC classification number: C07D213/79 ,  C07D207/16 ,  C07D207/34 ,  C07D209/08 ,  C07D209/18 ,  C07D209/42 ,  C07D211/62 ,  C07D213/55 ,  C07D215/48 ,  C07D233/54 ,  C07D233/64 ,  C07D235/06 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D277/68 ,  C07D279/22 ,  C07D307/54 ,  C07D307/68 ,  C07D307/71 ,  C07D307/85 ,  C07D311/12 ,  C07D333/24 ,  C07D333/38 ,  C07D333/70

Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.

Abstract translation: 式“IMAGE”的脒化合物及其药学上可接受的酸加成盐是新的化合物，可用作强抗胰蛋白酶，抗纤溶酶，抗激肽释放酶和抗凝血酶剂。 它们也可用作强大的抗补体剂。

公开(公告)号：US4898859A

公开(公告)日：1990-02-06

申请号：US165942

申请日：1988-03-09

Applicant: Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

Inventor： Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined, pharmaceutically acceptable salts thereof, composition containing the same and processes for preparing the same are disclosed. The compound is useful as an antimicrobial agent.

公开(公告)号：US4831026A

公开(公告)日：1989-05-16

申请号：US23602

申请日：1987-03-09

Applicant: Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

Inventor： Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Kouichi Tsuji

IPC: C07D505/00 ,  A61K31/535 ,  A61P31/04 ,  C07D498/04 ,  C07D507/04 ,  C07D507/06 ,  C07D507/08

CPC classification number: C07D498/04

Abstract: A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined, pharmaceutically acceptable salts thereof, esters of the carboxy group in the 4-position thereof and quaternary ammonium salts thereof, composition containing the same and processes for preparing the same are disclosed. The compound is useful as an antimicrobial compound.

Abstract translation: 式（1）的2-氧杂 - 异头孢烯化合物：其中R1，R2和R3如上定义，其药学上可接受的盐，其4-位的羧基酯和季铵盐 公开了含有该组合物的组合物及其制备方法。 该化合物可用作抗微生物化合物。

公开(公告)号：US4563527A

公开(公告)日：1986-01-07

申请号：US632350

申请日：1984-07-19

Applicant: Setsuro Fujii ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shin-ichi Watanabe ,  Toshiyuki Okutome ,  Yojiro Sakurai ,  Masateru Kurumi ,  Takuo Aoyama

Inventor： Setsuro Fujii ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shin-ichi Watanabe ,  Toshiyuki Okutome ,  Yojiro Sakurai ,  Masateru Kurumi ,  Takuo Aoyama

IPC: C07D307/68 ,  C07D307/85 ,  C07D333/38 ,  C07D405/12 ,  C07D307/54

CPC classification number: C07D405/12 ,  C07D307/68 ,  C07D307/85 ,  C07D333/38

Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.

Abstract translation: 式“IMAGE”的脒化合物及其药学上可接受的酸加成盐是新的化合物，可用作强抗胰蛋白酶，抗纤溶酶，抗激肽释放酶和抗凝血酶剂。 它们也可用作强大的抗补体剂。

公开(公告)号：US07065852B2

公开(公告)日：2006-06-27

申请号：US10450908

申请日：2001-12-26

Applicant: Kimio Sudo ,  Ryuji Uda

Inventor： Kimio Sudo ,  Ryuji Uda

IPC: F16F9/32

CPC classification number: F16F9/3214 ,  B23P15/10 ,  B23P2700/14 ,  F16F9/3485 ,  Y10T29/49828 ,  Y10T29/49829 ,  Y10T29/4984

Abstract: A method of manufacturing a hydraulic shock absorber is provided with a piston main body manufacturing step 21 including the process of sintering of the piston main body and the process of forming of the molded sealing are performed, a piston assembly manufacturing step 22 including process of forming of the throttle oil passage on the piston main body manufactured in the piston main body manufacturing step 21 and the assembly of valves onto the piston main body, and a hydraulic shock absorber manufacturing step 23 for manufacturing a hydraulic shock absorber using the piston assembly. In this manner, it is not necessary to provide for an intermediate inventory between each process. Furthermore inventory monitoring processes are simplified in the piston main body manufacturing step and productivity is increased since it is not necessary to monitor the inventory level with respect to a plurality of piston assembly types with different valves or throttle hydraulic passages.

Abstract translation: 一种制造液压减震器的方法设置有包括活塞主体的烧结过程的活塞主体制造步骤21和模制密封的形成过程，活塞组件制造步骤22包括形成 在活塞主体制造步骤21中制造的活塞主体上的节气门油通道以及将阀组装到活塞主体上的液压减震器制造步骤23，以及用于制造使用该活塞组件的液压减震器的液压减震器制造步骤23。 以这种方式，不需要在每个处理之间提供中间库存。 此外，在活塞主体制造步骤中简化了库存监控过程，并且由于不需要监视相对于具有不同阀或节流液压通道的多个活塞组件类型的库存水平，生产率增加。

公开(公告)号：US5262411A

公开(公告)日：1993-11-16

申请号：US635441

申请日：1990-12-28

Applicant: Tetsuhiko Shirasaka ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Koichi Tsuji

Inventor： Tetsuhiko Shirasaka ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Koichi Tsuji

IPC: A61K31/545 ,  C07D498/04 ,  C07D501/00 ,  C07D501/36 ,  C07D513/04 ,  C07D417/12 ,  A61K31/54

CPC classification number: C07D513/04 ,  C07D501/00

Abstract: There is provided a cephalosporin derivative represented by the general formula (1): ##STR1## wherein R.sup.101, R.sup.102, R.sup.103 and Y.sup.101 are as difined; the general formula (2): ##STR2## wherein R.sup.201, R.sup.202 and R.sup.203 are as defined above; the general formula (3): ##STR3## wherein R.sup.301, R.sup.302, Y.sup.301, Y.sup.302 and A.sup.301 are as defined; or pharmaceutically acceptable salt thereof. The compound is useful as an active ingredient of antimicrobial agent.

公开(公告)号：US4950662A

公开(公告)日：1990-08-21

申请号：US261293

申请日：1988-10-24

Applicant: Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Koichi Tsuji

Inventor： Setsuro Fujii ,  Hiroshi Ishikawa ,  Koichi Yasumura ,  Koichiro Jitsukawa ,  Sachio Toyama ,  Hidetsugu Tsubouchi ,  Kimio Sudo ,  Koichi Tsuji

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: There is described a 2-oxa-isocephem compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined, and R.sup.3 is a group of the formula: ##STR2## wherein n, m, R.sup.6, R.sup.7, B.sup.- and l are as defined, or pharmaceutically acceptable salt thereof. The compound has antimicrobial activity.

Abstract translation: 描述了下式的2-氧杂 - 异头孢烯化合物：其中R1，R2和R4如上所定义，R3是下式的基团：其中n，m，R6，R7 ，B和I定义，或其药学上可接受的盐。 该化合物具有抗菌活性。

公开(公告)号：US4820730A

公开(公告)日：1989-04-11

申请号：US217405

申请日：1988-07-11

Applicant: Setsurou Fujii ,  Toshiyuki Okutome ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shinichi Watanabe ,  Masateru Kurumi ,  Takuo Aoyama

Inventor： Setsurou Fujii ,  Toshiyuki Okutome ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shinichi Watanabe ,  Masateru Kurumi ,  Takuo Aoyama

IPC: A61K31/24 ,  A61K31/245 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P1/18 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P43/00 ,  C07C277/08 ,  C07C279/18 ,  C07D233/50 ,  C07D233/88 ,  C07D235/30 ,  C07D239/14 ,  C12N9/99 ,  C07C129/12

CPC classification number: C07C279/18 ,  C07D233/50 ,  C07D233/88 ,  C07D235/30

Abstract: Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.

公开(公告)号：US4777182A

公开(公告)日：1988-10-11

申请号：US835853

申请日：1986-02-24

Applicant: Setsurou Fujii ,  Toshiyuki Okutome ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shinichi Watanabe ,  Masateru Kurumi ,  Takuo Aoyama

Inventor： Setsurou Fujii ,  Toshiyuki Okutome ,  Toyoo Nakayama ,  Shigeki Nunomura ,  Kimio Sudo ,  Shinichi Watanabe ,  Masateru Kurumi ,  Takuo Aoyama

IPC: A61K31/24 ,  A61K31/245 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P1/18 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P43/00 ,  C07C277/08 ,  C07C279/18 ,  C07D233/50 ,  C07D233/88 ,  C07D235/30 ,  C07D239/14 ,  C12N9/99 ,  A61K31/505

CPC classification number: C07C279/18 ,  C07D233/50 ,  C07D233/88 ,  C07D235/30

Abstract: Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.

Abstract translation: PCT No.PCT / JP85 / 00392 Sec。 一九八六年二月二十四日 102（e）日期1986年2月24日PCT提交1985年7月12日PCT公布。 公开号WO86 / 00893 日本2月13日，1986年。式（I）的化合物（Ⅰ）及其药学上可接受的酸加成盐是新的，可用作抗胰蛋白酶，抗纤溶酶，抗激肽释放酶，抗凝血酶 和可以口服给药的抗补体剂。 这些脒化合物可以通过式（II）的羧酸化合物（II）或其反应性中间体与式（III）的6-脒基-2-萘酚（III）或 优选其酸加成盐。