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12 条记录 (耗时 0.015 秒)

    Process for the preparation of carbonyl compounds by cleavage of hydroxycarboxylic acids
    2.
    发明授权
    Process for the preparation of carbonyl compounds by cleavage of hydroxycarboxylic acids 失效
    通过羟基羧酸的切割制备羰基化合物的方法

    公开(公告)号：US06506942B2

    公开(公告)日：2003-01-14

    申请号：US09976988

    申请日：2001-10-12

    申请人： Klas Sorger ,  Hermann Petersen ,  Juergen Stohrer

    发明人： Klas Sorger ,  Hermann Petersen ,  Juergen Stohrer

    IPC分类号： C07C4500

    CPC分类号： C07B41/06 ,  C07C45/512

    摘要： The invention relates to a process for the preparation of a carbonyl compound of the general formula (1) R1R2C═O  (1), in which a &bgr;-hydroxycarboxylic acid or its salt of the general formula (2) R1R2C(OH)—CR3R4—COOM  (2) is cleaved in the presence of a Brönstedt base which is selected from hydroxides, alkanolates, oxides, amides and hydrides of the alkali metals and alkaline earth metals, and in the presence of a hydroxyl-free solvent, R1, R2, R3, R4 and M having the meanings from claim 1.

    摘要翻译： 本发明涉及一种制备通式（1）的羰基化合物的方法，其中在布朗斯台德碱存在下将β-羟基羧酸或其通式（2）的盐切割，其选自 碱金属和碱土金属的氢氧化物，链烷醇化物，氧化物，酰胺和氢化物，以及在没有权利要求1的含义的无羟基溶剂R1，R2，R3，R4和M的存在下。

    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof
    4.
    发明授权
    Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof 失效
    光学活性3-烷基羧酸的制备方法及其中间产物

    公开(公告)号：US07534908B2

    公开(公告)日：2009-05-19

    申请号：US11569452

    申请日：2005-05-12

    申请人： Klas Sorger ,  Jürgen Stohrer

    发明人： Klas Sorger ,  Jürgen Stohrer

    IPC分类号： C07C51/38 ,  C07C53/126 ,  C07C55/02 ,  C07B53/00

    CPC分类号： C07C51/09 ,  C07B2200/07 ,  C07C51/38 ,  C07C67/343 ,  C07C55/02 ,  C07C53/126 ,  C07C69/34

    摘要： An enantioselective method for producing optically active 3-alkyl carboxylic acids comprises transforming an optically active secondary alcohol into an optically active, activated compound by introducing a leaving group; reacting the activated compound with a malonic acid derivative to obtain an optically active, alkylated malonic acid compound, the reaction taking place exclusively in ether and/or carboxylic acid ester solvents and one or more aprotic polar solvents or alcohols as a cosolvent in a maximum proportion of 30 volume percent of total solvent, wherein the added cosolvent is not hexamethyl phosphoric acid triamide; the malonic acid compound is hydrolyzed if necessary to obtain the corresponding acid; and the corresponding acid is decarboxylated.

    摘要翻译： 用于制备光学活性3-烷基羧酸的对映选择性方法包括通过引入离去基团将光学活性仲醇转化为光学活性化合物; 使活化的化合物与丙二酸衍生物反应，得到光学活性的烷基化丙二酸化合物，该反应仅在醚和/或羧酸酯溶剂和一种或多种非质子极性溶剂或醇中作为共溶剂以最大比例进行 的总溶剂的30体积％，其中所添加的共溶剂不是六甲基磷酸三酰胺; 如果需要，丙二酸化合物被水解得到相应的酸; 并将相应的酸脱羧。

    Method for the Production of Optically Active 3-Alkyl Carboxylic Acids and the Intermediate Products Thereof
    7.
    发明申请
    Method for the Production of Optically Active 3-Alkyl Carboxylic Acids and the Intermediate Products Thereof 失效
    光活性3-烷基羧酸及其中间产物的制备方法

    公开(公告)号：US20070225519A1

    公开(公告)日：2007-09-27

    申请号：US11569452

    申请日：2005-05-12

    申请人： Klas Sorger ,  Jurgen Stohrer

    发明人： Klas Sorger ,  Jurgen Stohrer

    IPC分类号： C07B57/00

    CPC分类号： C07C51/09 ,  C07B2200/07 ,  C07C51/38 ,  C07C67/343 ,  C07C55/02 ,  C07C53/126 ,  C07C69/34

    摘要： An enantioselective method for producing optically active 3-alkyl carboxylic acids comprises transforming an optically active secondary alcohol into an optically active, activated compound by introducing a leaving group; reacting the activated compound with a malonic acid derivative to obtain an optically active, alkylated malonic acid compound, the reaction taking place exclusively in ether and/or carboxylic acid ester solvents and one or more aprotic polar solvents or alcohols as a cosolvent in a maximum proportion of 30 volume percent of total solvent, wherein the added cosolvent is not hexamethyl phosphoric acid triamide; the malonic acid compound is hydrolyzed if necessary to obtain the corresponding acid; and the corresponding acid is decarboxylated.

    摘要翻译： 用于制备光学活性3-烷基羧酸的对映选择性方法包括通过引入离去基团将光学活性仲醇转化为光学活性化合物; 使活化的化合物与丙二酸衍生物反应，得到光学活性的烷基化丙二酸化合物，该反应仅在醚和/或羧酸酯溶剂和一种或多种非质子极性溶剂或醇中作为共溶剂以最大比例进行 的总溶剂的30体积％，其中所添加的共溶剂不是六甲基磷酸三酰胺; 如果需要，丙二酸化合物被水解得到相应的酸; 并将相应的酸脱羧。

    Process for preparing beta-keto nitriles and salts thereof
    8.
    发明申请
    Process for preparing beta-keto nitriles and salts thereof 审中-公开
    制备β-酮腈及其盐的方法

    公开(公告)号：US20070142661A1

    公开(公告)日：2007-06-21

    申请号：US11605604

    申请日：2006-11-29

    申请人： Klas Sorger ,  Jurgen Stohrer

    发明人： Klas Sorger ,  Jurgen Stohrer

    IPC分类号： C07C253/22

    CPC分类号： C08F2/20

    摘要： A process for preparing β-keto nitrites or salts thereof is provided by reacting a nitrile with a carboxylic ester in the presence of an alkali metal alkoxide or alkaline earth metal alkoxide. Alcohol formed as a by-product is distilled off. The volume of alcohol distilled off is continually replaced by metering in an essentially equal volume of nitrile. The nitrile is provided in excess based on the carboxylic ester to be converted.

    摘要翻译： 通过在碱金属醇盐或碱土金属醇盐的存在下使腈与羧酸酯反应来提供制备β-酮亚硝酸盐或其盐的方法。 蒸馏出作为副产物形成的醇。 蒸馏出的醇的体积通过在基本上相等体积的腈中的计量来连续替换。 基于待转化的羧酸酯，过量提供腈。