-
1.发明申请公开(公告)号：US20190030076A1
公开(公告)日：2019-01-31
申请号：US15771853
申请日：2016-10-27
申请人： Kyu Boem HAN , EHLBIO CO., LTD.
发明人： Kyu Boem HAN , Hong Ki LEE , Seong Hun LEE
IPC分类号： A61K35/28 , C12N5/0775 , A61L27/38 , A61L27/54 , A61P37/06
摘要： The present invention relates to a composition containing cells, cultured by adding 15-PGDH inhibitor to PGE2-expressing cells, or a culture thereof and a use thereof. More specifically, the present invention relates to: a pharmaceutical composition, containing cells, cultured by adding 15-PGDH inhibitor to PGE2-expressing cells, or a culture thereof, for the prevention or treatment of immunological diseases, inflammatory diseases, or wounds; a method for inhibiting an immune response, an inflammatory response, or wounds in a subject, the method comprising a step for administering the pharmaceutical composition, or the cells or the culture thereof, to the subject; a method for preparing an immunosuppressive agent, an antiinflammatory agent, or a wound healing agent, using the cells or the culture thereof; a method for preparing PGE2, the method comprising a step for adding a 15-PGDH inhibitor to PGE2-expressing cells, followed by culturing; an implant comprising PGE2-expressing cells and a 15-PGDH inhibitor; a method for preparing the implant; a complex comprising PGE2-expressing cells and a 15-PGDH inhibitor; and a culture obtained by adding a 15-PGDH inhibitor to PGE2-expressing cells.
-
公开(公告)号：US09605015B2
公开(公告)日：2017-03-28
申请号：US14369869
申请日：2012-08-31
申请人： Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
发明人： Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
IPC分类号： C07H15/26 , C12P19/62 , C07H17/08 , C07D493/08
CPC分类号： C07H17/08 , C07D493/08 , C07H15/26 , C12P19/62
摘要： The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
-
3.发明申请NOVEL POLYENE COMPOUND, METHOD FOR PREPARING THE SAME, AND ANTIFUNGAL DRUG COMPRISING NOVEL POLYENE COMPOUND ASACTIVE INGREDIENT 有权新型聚戊烯化合物，其制备方法和包含新型多元醇化合物的抗真菌药物公开(公告)号：US20140371436A1
公开(公告)日：2014-12-18
申请号：US14369869
申请日：2012-08-31
申请人： Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
发明人： Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
CPC分类号： C07H17/08 , C07D493/08 , C07H15/26 , C12P19/62
摘要： The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
摘要翻译： 本发明涉及类似于制霉菌素的新型多烯化合物，其制备方法，以及包含新型多烯化合物作为活性成分的抗真菌药物。 与包含一种糖的制霉菌素相比，与制霉菌素类似的多烯化合物，NNP显示出300倍的溶解度和10倍的细胞毒性，同时保持抗真菌活性，因此可用于开发具有改善的溶解度和更少的新型多烯抗真菌剂 在药代动力学方面的毒性。
-
4.发明授权Staphylococcal enterotoxin SEC-SER, expression vector and host cell, production method thereof, and manufacturing method of vaccine 失效葡萄球菌肠毒素SEC-SER，表达载体和宿主细胞，其制备方法和疫苗的制造方法公开(公告)号：US07223412B1
公开(公告)日：2007-05-29
申请号：US10203536
申请日：2000-10-31
申请人： Hong-Kyun Lee , Yong-Ho Park , Kyu-Boem Han , Byoung-Sun Chang , Yong-Jun Lee
发明人： Hong-Kyun Lee , Yong-Ho Park , Kyu-Boem Han , Byoung-Sun Chang , Yong-Jun Lee
CPC分类号： C07K14/31 , A61K39/00 , Y10S424/832 , Y10S530/825
摘要： The present invention relates to a method of producing recombinant modified Staphylococcal toxin having improved stability, comprising the steps of preparing a modified toxin in which a specific amino acid sequence is substituted and a vector for expressing the modified toxin, and culturing E. coli transformed with the vector, and a use thereof for the vaccine.
摘要翻译： 本发明涉及一种具有改善的稳定性的重组改性葡萄球菌毒素的制备方法，包括以下步骤：制备其中取代特定氨基酸序列的修饰毒素和用于表达经修饰的毒素的载体，并培养用 载体及其用于疫苗的用途。
-
-
-
搜索结果
4 条记录 (耗时 0.009 秒)
