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    ACELLULAR DERMAL GRAFT
    4.
    发明申请
    ACELLULAR DERMAL GRAFT 有权

    公开(公告)号：US20150057751A1

    公开(公告)日：2015-02-26

    申请号：US14484031

    申请日：2014-09-11

    申请人： Joon Yong KIM ,  Byung Moo KIM ,  L&C BIO CO., LTD.

    发明人： Joon Yong KIM ,  Byung Moo KIM ,  Yong Sup HWANG ,  Whan Chul LEE ,  Soo Jeong SEO ,  Ju Hee LEE ,  Hyung Gu KIM

    IPC分类号： A61F2/10

    CPC分类号： A61F2/105

    摘要： An acellular dermal graft is provided. The acellular dermal graft may be useful in minimizing side effects caused after transplantation since an environment favorable for formation of new blood vessels and proliferation of autologous tissues is provided by forming a multi-penetration structure in an acellular dermal tissue, removing a basement membrane layer and/or subjecting corners to slope cutting, and transplantation is stably performed within a short transplantation time due to improved extensibility and flexibility of tissues. The acellular dermal graft may be useful in reducing a time required to recover tissues after transplantation since the transplantation is stably performed due to improved grafting reaction with a host tissue by enhancing uptake of fibroblasts and promoting angiogenic activities. Also, the acellular dermal graft may be useful in maintaining smooth external appearance since hypodermic implantation is easily performed upon transplantation, and the skin at a graft site does not protrude after transplantation.

    摘要翻译： 提供无细胞真皮移植物。 无细胞真皮移植物可以用于最小化移植后引起的副作用，因为通过在无细胞真皮组织中形成多穿透结构，去除基底膜层和去除基底膜层来提供有利于新血管形成和自体组织增殖的环境 /或使拐角进行斜切割，并且由于组织的可伸展性和柔韧性的改善，在短的移植时间内稳定地进行移植。 无细胞真皮移植物可用于减少移植后恢复组织所需的时间，因为由于通过增强成纤维细胞的摄取和促进血管生成活性而改善与宿主组织的接枝反应，稳定地进行移植。 此外，无细胞真皮移植物可用于保持平滑的外观，因为移植后容易进行皮下注射，移植后移植部位的皮肤不会突出。

    COMPOSITION INJECTION DEVICE
    6.
    发明公开
    COMPOSITION INJECTION DEVICE 审中-公开

    公开(公告)号：US20240165340A1

    公开(公告)日：2024-05-23

    申请号：US18553107

    申请日：2021-03-29

    申请人： L&C BIO CO.,LTD.

    发明人： Kee Won LEE ,  Hyung Gu KIM ,  Whan Chul LEE

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31565

    摘要： A composition injection device includes a needle which is provided such that the ends of a distal part and proximal part thereof are open, and which is hollow such that a composition is injected thereto or discharged therefrom; a pressing member inserted into the needle to discharge the composition from the needle by pressurizing the composition injected into the needle; and a paddle which is formed to extend from the end of the distal part of the needle, and which enables the composition discharged from the needle to be applied, wherein the maximum width of the paddle is at most the outer diameter of the needle.

    Decellularized Nerve Graft and Method of Manufacturing the Same
    10.
    发明申请
    Decellularized Nerve Graft and Method of Manufacturing the Same 有权

    公开(公告)号：US20230041245A1

    公开(公告)日：2023-02-09

    申请号：US17791113

    申请日：2020-12-21

    申请人： L&C Bio Co., Ltd.

    发明人： Dong Hyun Nam ,  Sang Chul Kim ,  Kee Won Lee ,  Hyung Gu Kim ,  Whan Chul Lee

    IPC分类号： A61L27/36 ,  C12N5/071

    摘要： The present invention relates to a decellularized nerve graft using allogeneic and heterologous nervous tissues and a method of manufacturing the same.
    In the present invention, by using a low-concentration basic solution and a surfactant as a decellularization solution, cell and tissue toxicity caused by a solvent or surfactant remaining in the tissue may be minimized by minimizing the use of a basic solution and an anionic surfactant in the entire manufacturing process. In addition, a peristaltic pump may be used to maintain the tissue structure and effectively remove lipid and cells.