公开(公告)号：US11179454B2

公开(公告)日：2021-11-23

申请号：US16493638

申请日：2018-03-14

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Jon Cuccui ,  Brendan Wren ,  Alexandra Faulds-Pain

IPC: A61K39/02 ,  A61K39/104 ,  A61P31/04 ,  A61K39/116 ,  A61K39/00

Abstract: The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.

公开(公告)号：US10039814B2

公开(公告)日：2018-08-07

申请号：US15465312

申请日：2017-03-21

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Brendan Wren ,  Jon Cuccui ,  Madeleine Moule

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/38 ,  C07K14/21 ,  C12M1/00 ,  A61K45/06 ,  C07K14/195 ,  A61K47/64

Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.

公开(公告)号：US20150104489A1

公开(公告)日：2015-04-16

申请号：US14402389

申请日：2013-05-08

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Lisa Dawson ,  Brendan Wren

IPC: A61K38/46 ,  A61K45/06 ,  A01N43/90

CPC classification number: A61K38/465 ,  A01N43/90 ,  A61K38/482 ,  A61K45/06 ,  A61L2/16 ,  C11D3/38636 ,  C11D3/48 ,  C12Y301/21 ,  C12Y301/21001 ,  C12Y301/21002 ,  C12Y301/22001 ,  C12Y304/21064

Abstract: The invention relates to deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a pharmaceutical or veterinary composition or formulation comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a combination therapeutic comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a method of treating a mammal suspected of being infected with, or infected with, C. difficile comprising the use of at least deoxyribonuclease; a method of cleaning or sterilising a material or product comprising the use of at least deoxyribonuclease; and a cleaning or sterilising product impregnated with or containing at least deoxyribonuclease.

Abstract translation: 本发明涉及用于治疗怀疑或存在的艰难梭菌感染的脱氧核糖核酸酶; 至少包含脱氧核糖核酸酶的药物或兽药组合物或制剂，用于治疗怀疑或现存的艰难梭菌感染; 至少包含脱氧核糖核酸酶的组合治疗剂，用于治疗疑似或现存的艰难梭菌感染; 一种治疗怀疑被感染或受到艰难梭菌感染的哺乳动物的方法，包括至少使用脱氧核糖核酸酶; 一种清洁或消毒包含使用至少脱氧核糖核酸酶的材料或产品的方法; 和至少含有脱氧核糖核酸酶或至少含有脱氧核糖核酸酶的清洁或灭菌产品。

公开(公告)号：US20140093530A1

公开(公告)日：2014-04-03

申请号：US14049554

申请日：2013-10-09

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Kevin TETTEH ,  David Conway

IPC: C07K14/00 ,  G01N33/569

CPC classification number: C07K14/001 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/445 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/40 ,  G01N33/56905 ,  Y02A50/412

Abstract: The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of K1-type Plasmodium falciparum merozite surface antigen (MSP1) and fusion proteins containing that sequence in combination with additional epitope-containing sequences capable of inducing antibody and cellular immune responses to P. falciparum antigens

Abstract translation: 本发明涉及一种合成抗原序列，其表示来自K1型恶性疟原虫黑斑岩表面抗原（MSP1）的高度多态性嵌段2重复区的融合蛋白与含有表位的序列的组合的组合， 含有能够诱导针对恶性疟原虫抗原的抗体和细胞免疫应答的序列

公开(公告)号：US11890336B2

公开(公告)日：2024-02-06

申请号：US17098809

申请日：2020-11-16

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Brendan Wren ,  Jon Cuccui ,  Madeleine Moule

IPC: A61K39/00 ,  A61K39/02 ,  A61K47/64 ,  A61P31/04 ,  C07K14/195 ,  C12N15/74

CPC classification number: A61K39/0208 ,  A61K47/646 ,  A61P31/04 ,  C07K14/195 ,  C12N15/74 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/70 ,  C07K2319/40

Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.

公开(公告)号：US20210298297A1

公开(公告)日：2021-09-30

申请号：US17041602

申请日：2019-03-25

Applicant: Wageningen Universiteit ,  London School of Hygiene and Tropical Medicine

Inventor： Jetske Gudrun de Boer ,  Ailie Robinson ,  James George Logan ,  Joseph Johannes Antonius van Loon ,  Willem Takken

IPC: A01N35/02 ,  A01M1/02 ,  G01N33/497

Abstract: A mosquito attractant composition is described comprising heptanal, octanal, nonanal, (E)-2-octenal and (E)-2-decenal. More particularly a composition wherein the compounds are present in the following proportions: nonanal 1.00, octanal 0.32±0.16, heptanal 0.06±0.03, (E)-2-octenal 0.04±0.02 and (E)-2-decenal 0.13±0.065.

公开(公告)号：US10646562B2

公开(公告)日：2020-05-12

申请号：US15892624

申请日：2018-02-09

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Brendan Wren ,  Jon Cuccui ,  Sherif Abouelhadid

IPC: C12N9/10 ,  C12P21/00 ,  A61K39/02 ,  C12N15/70 ,  C12N15/74 ,  C12N1/20 ,  A61K39/09

Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.

公开(公告)号：US20200009241A1

公开(公告)日：2020-01-09

申请号：US16493638

申请日：2018-03-14

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Jon Cuccui ,  Brendan Wren ,  Alexandra Faulds-Pain

IPC: A61K39/104 ,  A61K39/02 ,  A61K39/116 ,  A61P31/04

Abstract: The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.

公开(公告)号：US20170196958A1

公开(公告)日：2017-07-13

申请号：US15465312

申请日：2017-03-21

Applicant: London School of Hygiene and Tropical Medicine

Inventor： Brendan Wren ,  Jon Cuccui ,  Madeleine Moule

IPC: A61K39/02 ,  C07K14/195

CPC classification number: A61K39/0208 ,  A61K45/06 ,  A61K47/646 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/70 ,  C07K14/195 ,  C07K14/21 ,  C12M23/00

Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.

公开(公告)号：US20150152141A1

公开(公告)日：2015-06-04

申请号：US14498317

申请日：2014-09-26

Applicant: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

Inventor： Ursula Gompels ,  David Dewin ,  Julie Catusse

IPC: C07K14/005 ,  A61K39/245 ,  C12N7/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/245 ,  A61K2039/53 ,  C07K14/523 ,  C12N7/00 ,  C12N2710/16034 ,  G01N2333/521 ,  G01N2500/00

Abstract: A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in treatment of a range of diseases, including cancers and HIV/AIDS, are described.

Abstract translation: 描述了一种新的细胞因子U83A，细胞因子的变体形式，具有广泛的针对趋化因子受体的激动和拮抗活性。 描述了趋化因子在治疗一系列疾病（包括癌症和艾滋病毒/艾滋病）中的用途。