公开(公告)号：US08870398B2

公开(公告)日：2014-10-28

申请号：US13373918

申请日：2011-12-06

申请人： W. Mark Haynes

发明人： W. Mark Haynes

IPC分类号： G03B15/00

CPC分类号： F21V17/04 ,  F21S10/02 ,  F21V17/007 ,  F21W2131/406

摘要： A collapsible snoot assembly for motion picture lighting fixture having a cylindrical body of a fabric material configured to expand and collapse along a longitudinal axis between expanded and collapsed positions having a biasing means for biasing the cylindrical body into an expanded position and a lighting fixture attachment means for securing the cylindrical body to a lighting fixture such that light projected from the lighting fixture is directed through the collapsible snoot assembly.

摘要翻译： 一种用于电影照明灯具的可折叠点烟器组件，其具有织物材料的圆柱形主体，其构造成沿着纵向轴线在膨胀位置和收缩位置之间膨胀和折叠，所述纵向轴线具有用于将所述圆柱体偏压到扩张位置的偏置装置和照明器具附接装置 用于将圆柱体固定到照明器具上，使得从照明器具投影的光被引导通过可折叠的鼻烟组件。

公开(公告)号：US20080016360A1

公开(公告)日：2008-01-17

申请号：US11779061

申请日：2007-07-17

申请人： Tony Rodriguez ,  Mark Haynes ,  Hugh Brunk ,  Geoffrey Rhoads

发明人： Tony Rodriguez ,  Mark Haynes ,  Hugh Brunk ,  Geoffrey Rhoads

IPC分类号： G06F1/26

CPC分类号： H04N21/4425 ,  G06T1/0021 ,  G06T2201/0051 ,  G06T2201/0065 ,  H04N17/004 ,  H04N21/8358

摘要： The invention provides methods for embedding digital watermarks for authentication of printed objects, and corresponding methods for authenticating these objects. One aspect of the invention is a method of embedding a digital watermark in a digital image to be printed on an object. The method embeds an auxiliary signal in the digital image so that the auxiliary signal is substantially imperceptible, yet machine readable. It converts the image to a halftone image using a halftoning process. If copies are made of the printed image, the image characteristics change due a change in the halftoning process used to create the copies. These changes are detected to determine whether a suspect document is authentic.

摘要翻译： 本发明提供了用于嵌入用于打印对象认证的数字水印的方法以及用于认证这些对象的相应方法。 本发明的一个方面是将数字水印嵌入到要打印在对象上的数字图像中的方法。 该方法在数字图像中嵌入辅助信号，使得辅助信号基本上不可察觉，但是机器可读。 它使用半色调处理将图像转换为半色调图像。 如果由打印的图像构成复印件，则由于用于创建复印件的半色调处理的变化，图像特性变化。 检测到这些更改以确定可疑文档是否可信。

公开(公告)号：US20170258146A1

公开(公告)日：2017-09-14

申请号：US15068719

申请日：2016-03-14

申请人： Mark Haynes

发明人： Mark Haynes

IPC分类号： A41B11/12

CPC分类号： A41B11/125 ,  A41B2300/32

摘要： A sock system for PURPOSE includes a sock that may be worn and the sock has a cuff. A strap is coupled to the sock and the strap may be manipulated. The strap is positioned on the cuff. The strap is manipulated to select a tightness of the cuff on a user. Thus, the user may select an amount of pressure the cuff imparts to the user.

公开(公告)号：US08843691B2

公开(公告)日：2014-09-23

申请号：US12343378

申请日：2008-12-23

申请人： William Calvert ,  Stephen Russell Boorman ,  Simon Mark Haynes

发明人： William Calvert ,  Stephen Russell Boorman ,  Simon Mark Haynes

IPC分类号： G06F13/00 ,  G06F11/14

CPC分类号： G06F3/0613 ,  G06F3/0659 ,  G06F3/0688 ,  G06F11/1441

摘要： Methods and systems for the prioritized erasure of data blocks in a flash storage device are provided. A data block in the flash storage device is selected for erasure based upon the number of valid data segments therein, thereby minimizing the number of data segments that are carried over to another data block before erasing the selected data block. The overhead of write operations in the flash storage device is therefore greatly reduced, and the overall performance thereof greatly increased. A method for managing memory operations in a flash storage device having a plurality of data blocks comprises the steps of selecting one of the plurality of data blocks for erasure based upon a number of valid data segments therein, and erasing the selected one of the plurality of data blocks.

摘要翻译： 提供了闪存存储设备中优先擦除数据块的方法和系统。 闪存存储设备中的数据块根据其中的有效数据段的数目被选择用于擦除，从而最小化在擦除所选择的数据块之前承载到另一个数据块的数据段的数量。 闪存存储装置中的写入操作的开销因此大大降低，并且其整体性能大大提高。 一种用于管理具有多个数据块的闪速存储装置中的存储器操作的方法，包括以下步骤：根据其中的有效数据段的数目，选择多个数据块中的一个用于擦除，并且擦除多个 数据块。

公开(公告)号：US08835506B2

公开(公告)日：2014-09-16

申请号：US12990334

申请日：2009-06-05

申请人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

发明人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

IPC分类号： A01N33/02 ,  A61K31/165 ,  A61K31/445

CPC分类号： A61K31/437 ,  A61K31/135 ,  A61K31/165 ,  A61K31/445 ,  A61K45/06 ,  A61N5/10

摘要： A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death. While the exact mechanism of cancer cell degradation and death is not completely understood, the treated cancer cells, including refractory prostate cancer cells, give indications of cell death through an autophagic mechanism. Pharmaceutical compositions related to the presently disclosed methods are also disclosed.

摘要翻译： 治疗和/或预防癌症的方法包括在癌细胞中引起增加的细胞内颗粒度的给药剂，至少足以抑制这些细胞增殖的量，优选以足以导致癌细胞死亡的量。 该方法特别涉及难治性癌症，特别是激素难治性前列腺癌。 所鉴定的试剂导致癌细胞中的细胞内颗粒度增加，并且将粘附的癌细胞转化为非贴壁癌细胞，导致癌细胞死亡。 使用本发明，癌细胞在相对低的药物浓度下经历增加的细胞内粒度，同时也抑制细胞增殖。 增加的浓度导致粘附的癌细胞转化为非粘附的癌细胞，然后转移到细胞死亡。 虽然癌细胞降解和死亡的确切机制尚未完全了解，但治疗的癌细胞（包括难治性前列腺癌细胞）通过自噬机制给予细胞死亡的指示。 还公开了与目前公开的方法相关的药物组合物。

公开(公告)号：US08572308B2

公开(公告)日：2013-10-29

申请号：US12492103

申请日：2009-06-25

申请人： Mark Moshayedi ,  William Calvert ,  Stephen Russell Boorman ,  Simon Mark Haynes

发明人： Mark Moshayedi ,  William Calvert ,  Stephen Russell Boorman ,  Simon Mark Haynes

IPC分类号： G06F12/00

CPC分类号： G06F3/0613 ,  G06F3/0659 ,  G06F3/0688 ,  G06F11/1441

摘要： A flash storage device comprises a plurality of data blocks, each data block comprising a plurality of data segments, a system memory, and a controller. The controller is configured to cache in the system memory a plurality of data sectors to be written, to write to a first one of the plurality of data segments a first one of the plurality of data sectors, to write to the first one of the plurality of data segments a first portion of a second one of the plurality of data sectors, and to write to a second one of the plurality of data segments a second portion of the second one of the plurality of data sectors.

摘要翻译： 闪存存储设备包括多个数据块，每个数据块包括多个数据段，系统存储器和控制器。 控制器被配置为在系统存储器中缓存要写入的多个数据扇区，以写入多个数据扇区中的第一个数据扇区中的第一个数据段中的第一个数据扇区，以写入多个数据扇区中的第一个 的数据段分割多个数据扇区中的第二个的第一部分，并且对多个数据段中的第二部分写入多个数据扇区中的第二个的第二部分。

公开(公告)号：US20120239851A1

公开(公告)日：2012-09-20

申请号：US12343378

申请日：2008-12-23

申请人： William CALVERT ,  Stephen Russell Boorman ,  Simon Mark Haynes

发明人： William CALVERT ,  Stephen Russell Boorman ,  Simon Mark Haynes

IPC分类号： G06F12/00 ,  G06F12/02

CPC分类号： G06F3/0613 ,  G06F3/0659 ,  G06F3/0688 ,  G06F11/1441

摘要： Methods and systems for the prioritized erasure of data blocks in a flash storage device are provided. A data block in the flash storage device is selected for erasure based upon the number of valid data segments therein, thereby minimizing the number of data segments that are carried over to another data block before erasing the selected data block. The overhead of write operations in the flash storage device is therefore greatly reduced, and the overall performance thereof greatly increased. A method for managing memory operations in a flash storage device having a plurality of data blocks comprises the steps of selecting one of the plurality of data blocks for erasure based upon a number of valid data segments therein, and erasing the selected one of the plurality of data blocks.

摘要翻译： 提供了闪存存储设备中优先擦除数据块的方法和系统。 闪存存储设备中的数据块根据其中的有效数据段的数目被选择用于擦除，从而最小化在擦除所选择的数据块之前承载到另一个数据块的数据段的数量。 闪存存储装置中的写入操作的开销因此大大降低，并且其整体性能大大提高。 一种用于管理具有多个数据块的闪速存储装置中的存储器操作的方法，包括以下步骤：根据其中的有效数据段的数目，选择多个数据块中的一个用于擦除，并且擦除多个 数据块。

公开(公告)号：US20110224141A1

公开(公告)日：2011-09-15

申请号：US12990334

申请日：2009-06-05

申请人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

发明人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

IPC分类号： A61K31/454 ,  A61K31/496 ,  A61K38/08 ,  A61K31/56 ,  A61P35/00

CPC分类号： A61K31/437 ,  A61K31/135 ,  A61K31/165 ,  A61K31/445 ,  A61K45/06 ,  A61N5/10

摘要： A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death. While the exact mechanism of cancer cell degradation and death is not completely understood, the treated cancer cells, including refractory prostate cancer cells, give indications of cell death through an autophagic mechanism. Pharmaceutical compositions related to the presently disclosed methods are also disclosed.

摘要翻译： 治疗和/或预防癌症的方法包括在癌细胞中引起增加的细胞内颗粒度的给药剂，至少足以抑制这些细胞增殖的量，优选以足以导致癌细胞死亡的量。 该方法特别涉及难治性癌症，特别是激素难治性前列腺癌。 所鉴定的试剂导致癌细胞中的细胞内颗粒度增加，并且将粘附的癌细胞转化为非贴壁癌细胞，导致癌细胞死亡。 使用本发明，癌细胞在相对低的药物浓度下经历增加的细胞内粒度，同时也抑制细胞增殖。 增加的浓度导致粘附的癌细胞转化为非粘附的癌细胞，然后转移到细胞死亡。 虽然癌细胞降解和死亡的确切机制尚未完全了解，但治疗的癌细胞（包括难治性前列腺癌细胞）通过自噬机制给予细胞死亡的指示。 还公开了与目前公开的方法相关的药物组合物。

公开(公告)号：US20050202467A1

公开(公告)日：2005-09-15

申请号：US11016991

申请日：2004-12-20

申请人： Bradford Jameson ,  Anna Tretiakova ,  Mark Haynes

发明人： Bradford Jameson ,  Anna Tretiakova ,  Mark Haynes

IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/94

CPC分类号： C07K14/70571 ,  G01N33/942 ,  G01N2500/02

摘要： The present invention relates to a novel spliced 5-HT1A receptor and nucleic acids encoding the same and the polypeptides encoded thereby.

摘要翻译： 本发明涉及新的剪接的5-HT1A受体和编码它的核酸以及由此编码的多肽。

公开(公告)号：US06261962B1

公开(公告)日：2001-07-17

申请号：US08904954

申请日：1997-08-01

申请人： Jyoti Kiron Bhardwaj ,  Huma Ashraf ,  Babak Khamsehpour ,  Janet Hopkins ,  Alan Michael Hynes ,  Martin Edward Ryan ,  David Mark Haynes

发明人： Jyoti Kiron Bhardwaj ,  Huma Ashraf ,  Babak Khamsehpour ,  Janet Hopkins ,  Alan Michael Hynes ,  Martin Edward Ryan ,  David Mark Haynes

IPC分类号： H01L21311

CPC分类号： H01L21/30655 ,  H01L21/3086 ,  H01L21/312

摘要： A sidewall passivation layer is deposited on an etched feature in a semiconductor substrate with a hydrocarbon deposition gas by introducing H2, determining certain mixture percentages for the hydrocarbon gas/H2 mix at which the etch rate for the substrate peaks, the etch rate begins to rise from a generally steady state, and/or the etch rate falls to zero, and then maintaining the mixture percentage within a selected range. Where the hydrocarbon gas/H2 mix is maintained at a percentage between the steady-state etch rate percentage and the peak etch rate percentage, then relatively high ion energies are used. Where the hydrocarbon gas/H2 mix is maintained at a percentage between the peak etch rate percentage and the percentage where the etch rate falls to zero, then relatively low ion energies are used. High aspect-ratio features in a semiconductor substrate can be produced by performing alternating etching and depositing a passivation layer on the substrate, where the deposition is performed according to the above-described deposition process.

摘要翻译： 侧壁钝化层通过引入H2而沉积在具有烃沉积气体的半导体衬底的蚀刻特征上，确定烃基气体/ H2混合物的某些混合百分比，其中衬底的蚀刻速率达峰值，蚀刻速率开始上升 和/或蚀刻速率降至零，然后将混合物百分比保持在所选择的范围内。 当烃气/ H2混合物保持在稳态蚀刻速率百分比和峰蚀刻速率百分比之间的百分比时，则使用相对较高的离子能量。 当烃气体/ H 2混合物保持在峰值蚀刻速率百分比与蚀刻速率降至零的百分比之间的百分比时，则使用相对低的离子能量。 半导体衬底中的高纵横比特征可以通过在衬底上执行交替蚀刻和沉积钝化层来制造，其中根据上述沉积工艺执行沉积。