ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH CORRELATED DOUBLE SAMPLING
    3.
    发明申请
    ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH CORRELATED DOUBLE SAMPLING 有权
    具有相关双重采样的主动化学感应传感器

    公开(公告)号:US20120329044A1

    公开(公告)日:2012-12-27

    申请号:US13599913

    申请日:2012-08-30

    申请人: Mark MILGREW

    发明人: Mark MILGREW

    IPC分类号: G01N27/00 C12M1/40

    摘要: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    摘要翻译: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置,例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号(以及信噪比)。

    ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH IN-SENSOR CURRENT SOURCES
    4.
    发明申请
    ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH IN-SENSOR CURRENT SOURCES 有权
    具有传感器电流源的主动化学感应传感器

    公开(公告)号:US20120325683A1

    公开(公告)日:2012-12-27

    申请号:US13599899

    申请日:2012-08-30

    申请人: Mark MILGREW

    发明人: Mark MILGREW

    摘要: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    摘要翻译: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置,例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号(以及信噪比)。

    Active chemically-sensitive sensors with reset switch
    6.
    发明授权
    Active chemically-sensitive sensors with reset switch 有权
    具有复位开关的活性化学敏感传感器

    公开(公告)号:US08748947B2

    公开(公告)日:2014-06-10

    申请号:US13599918

    申请日:2012-08-30

    申请人: Mark Milgrew

    发明人: Mark Milgrew

    IPC分类号: G01N27/403

    摘要: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    摘要翻译: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置,例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号(以及信噪比)。

    Array configuration and readout scheme
    7.
    发明授权
    Array configuration and readout scheme 有权
    阵列配置和读出方案

    公开(公告)号:US08731847B2

    公开(公告)日:2014-05-20

    申请号:US13174514

    申请日:2011-06-30

    IPC分类号: G06F19/00 G01N27/414

    摘要: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    摘要翻译: 所描述的实施例可以提供化学检测电路,其可以包括在第一侧的多个第一输出电路和在化学检测电路的第二侧的多个第二输出电路。 化学检测电路还可以包括多个像素瓦片,每个瓷砖分别放置在相应的第一和第二输出电路对之间。 每个瓦片可以包括四个像素象限。 每个象限可以具有与第二列交错的指定的第一列的列。 每个第一列可以耦合到第一和第二象限中的相应的第一输出电路,以及耦合到第三和第四象限中的相应的第二输出电路。 每个第二列可以耦合到第一和第二象限中的相应的第二输出电路,以及耦合到第三和第四象限中的相应的第一输出电路。

    Active chemically-sensitive sensors
    8.
    发明授权
    Active chemically-sensitive sensors 有权
    活性化学敏感传感器

    公开(公告)号:US08698212B2

    公开(公告)日:2014-04-15

    申请号:US13599894

    申请日:2012-08-30

    申请人: Mark Milgrew

    发明人: Mark Milgrew

    IPC分类号: G01N27/403

    摘要: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    摘要翻译: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置,例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号(以及信噪比)。

    MICROWELL STRUCTURES FOR CHEMICALLY-SENSITIVE SENSOR ARRAYS
    9.
    发明申请
    MICROWELL STRUCTURES FOR CHEMICALLY-SENSITIVE SENSOR ARRAYS 审中-公开
    用于化学敏感传感器阵列的MICROWELL结构

    公开(公告)号:US20120326213A1

    公开(公告)日:2012-12-27

    申请号:US13599859

    申请日:2012-08-30

    IPC分类号: G01N27/414

    摘要: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    摘要翻译: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置,例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号(以及信噪比)。