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1.发明申请公开(公告)号：US20080212960A1
公开(公告)日：2008-09-04
申请号：US11978138
申请日：2007-10-26
Applicant: Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
Inventor： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2201/126
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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2.发明授权公开(公告)号：US08703422B2
公开(公告)日：2014-04-22
申请号：US13034199
申请日：2011-02-24
Applicant: Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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3.发明授权公开(公告)号：US07995202B2
公开(公告)日：2011-08-09
申请号：US11704689
申请日：2007-02-09
Applicant: Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
Inventor： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
IPC: G01J3/30
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2201/126
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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公开(公告)号：US20100075309A1
公开(公告)日：2010-03-25
申请号：US12413226
申请日：2009-03-27
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
IPC: C12Q1/68 , G01N21/75 , C12Q1/48 , C12Q1/00 , C12Q1/44 , G01N33/48 , G01N21/76 , C12P19/34 , G06F19/00
CPC classification number: C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
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5.发明申请公开(公告)号：US20090024331A1
公开(公告)日：2009-01-22
申请号：US12134186
申请日：2008-06-05
Applicant: Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6869 , G06F19/22 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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Patent Agency Ranking
公开(公告)号：US08383369B2
公开(公告)日：2013-02-26
申请号：US12561221
申请日：2009-09-16
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
CPC classification number: G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
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7.发明授权Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权用于同时实时监测来自多个来源的光信号的方法和系统公开(公告)号：US08264687B2
公开(公告)日：2012-09-11
申请号：US13102551
申请日：2011-05-06
Applicant: Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
Inventor： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
IPC: G01N21/25
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2201/126
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。
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8.发明授权公开(公告)号：US08182993B2
公开(公告)日：2012-05-22
申请号：US12134186
申请日：2008-06-05
Applicant: Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6869 , G06F19/22 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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公开(公告)号：US08143030B2
公开(公告)日：2012-03-27
申请号：US12413226
申请日：2009-03-27
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
CPC classification number: C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
Abstract translation: 提供了在分析反应期间执行间歇检测的方法，装置和系统。 这种方法有助于从不同的反应时间收集反应数据。 此外，这样的方法可用于在给定的反应时间下降低照明分析反应中的一种或多种反应物的光致损伤。 在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。
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公开(公告)号：US20100075327A1
公开(公告)日：2010-03-25
申请号：US12561221
申请日：2009-09-16
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
CPC classification number: G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
Abstract translation: 提供了在分析反应期间执行间歇检测的方法，装置和系统。 这种方法有助于从不同的反应时间收集反应数据。 此外，这样的方法可用于在给定的反应时间下降低照明分析反应中一种或多种反应物的光诱导损伤。 在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。
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