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8 条记录 (耗时 0.061 秒)

    Benzodiazepine derivatives for treating hepatitis C infection
    4.
    发明授权
    Benzodiazepine derivatives for treating hepatitis C infection 失效

    公开(公告)号：US08039616B2

    公开(公告)日：2011-10-18

    申请号：US12067318

    申请日：2005-09-19

    申请人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    发明人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    IPC分类号： C07D243/12 ,  A61K31/55

    CPC分类号： C07D243/24 ,  A61K31/5513

    摘要： Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R′, —CONR′R″, —NH—CO—R′, —S(O)R′, —S(O)2R′, —NH—S(O)2R′, —S(O)NR′R″ or —S(O)2NR′R″, wherein each R′ and R″ is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or —XR6; —X represents —CO—, —S(O)— or —S(O)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 alkyl)-O—, heteroaryl-(C1-6 alkyl)-O—, carbocyclyl-(C1-6 alkyl)-O—, heterocyclyl-(C1-6 alkyl)-O— or —NR′R″ wherein each R′ and R″ is the same or different and represents hydrogen, C1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)- or heterocyclyl-(C1-6 alkyl)-.

    BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION
    5.
    发明申请
    BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION 失效

    公开(公告)号：US20090318427A1

    公开(公告)日：2009-12-24

    申请号：US12067318

    申请日：2005-09-19

    申请人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    发明人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    IPC分类号： A61K31/5513 ,  A61P31/12 ,  C07D243/24

    CPC分类号： C07D243/24 ,  A61K31/5513

    摘要： Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R′, —CONR′R″, —NH—C0-R′, —S(O)R′, —S(O)2R′, —NH—S(O)2R′, —S(O)NR′R″ or —S(O)2NR′R″, wherein each R′ and R″ is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or —XR6; —X represents —CO—, —S(O)— or —S(O)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 alkyl)-O—, heteroaryl-(C1-6 alkyl)-O—, carbocyclyl-(C1-6 alkyl)-O—, heterocyclyl-(C1-6 alkyl)-O— or —NR′R″ wherein each R′ and R″ is the same or different and represents hydrogen, C1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)- or heterocyclyl-(C1-6 alkyl)-.

    FULL FUNCTION PRECISION WELDING SYSTEM
    6.
    发明申请
    FULL FUNCTION PRECISION WELDING SYSTEM 审中-公开
    全功能精密焊接系统

    公开(公告)号：US20070297556A1

    公开(公告)日：2007-12-27

    申请号：US11752733

    申请日：2007-05-23

    申请人： Keith Spencer ,  Bradley Powell

    发明人： Keith Spencer ,  Bradley Powell

    IPC分类号： G21C17/00

    CPC分类号： G21C17/017 ,  B23K9/0286 ,  B23K2101/06

    摘要： A welding system for performing a welding process on a pipe in a confined space includes a motor housing, a weld head assembly and an insertion tube that extends between the motor housing and the weld head assembly with the weld head assembly remote from the motor housing. The motor housing is supported on a platform for rotational and translational movement of the weld head assembly and houses a motor for positioning the weld head assembly relative to the pipe. The weld head assembly includes a clamp assembly for attaching the weld head assembly to the pipe and a weld tool assembly mounted adjacent the clamp assembly for welding the pipe. An arc length gear and a travel gear adjust the distance between a torch assembly and the pipe and adjust the location of the torch assembly around the pipe when the weld head assembly is attached to the pipe.

    摘要翻译： 用于在密闭空间中的管子上执行焊接过程的焊接系统包括马达壳体，焊接头组件和插入管，其在马达壳体和焊接头组件之间延伸，焊头组件远离马达壳体。 电动机壳体支撑在用于焊头组件的旋转和平移运动的平台上，并且容纳用于相对于管定位焊头组件的电动机。 焊头组件包括用于将焊接头组件附接到管道的夹具组件和邻近夹具组件安装以焊接管道的焊接工具组件。 电弧长度齿轮和行走齿轮调节焊枪组件和管道之间的距离，并且当焊头组件附接到管道时调整焊枪组件在管道周围的位置。

    Carbonylamino-benzimidazole derivatives as androgen receptor modulators
    8.
    发明申请
    Carbonylamino-benzimidazole derivatives as androgen receptor modulators 失效

    公开(公告)号：US20060036098A1

    公开(公告)日：2006-02-16

    申请号：US10533259

    申请日：2003-10-28

    申请人： Yuntae Kim ,  Barbara Hanney ,  Mark Duggan ,  Keith Spencer

    发明人： Yuntae Kim ,  Barbara Hanney ,  Mark Duggan ,  Keith Spencer

    IPC分类号： C07D403/02 ,  A61K31/4184

    CPC分类号： C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07D417/14

    摘要： Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.