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公开(公告)号：US08791238B2
公开(公告)日：2014-07-29
申请号：US12072959
申请日：2008-02-29
申请人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
发明人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
CPC分类号： C12N15/1044 , C07K14/00 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6872
摘要： The invention relates to modified proteins of the superfamily of “ubiquitin-like proteins”, proteins that have a ubiquitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention also relates to a method for the production and utilization of said proteins.
摘要翻译： 本发明涉及“遍在蛋白样蛋白”的超家族的修饰蛋白质，具有泛素样折叠的蛋白质及其片段或融合蛋白质。 作为所述修饰的结果，蛋白质相对于先前不存在的预定结合配偶体具有结合亲合力。 本发明还涉及生产和利用所述蛋白质的方法。
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2.发明申请公开(公告)号：US20060099686A1
公开(公告)日：2006-05-11
申请号：US11283332
申请日：2005-11-18
申请人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
发明人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
CPC分类号： C12N15/1044 , C07K14/00 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6872
摘要： The invention relates to modified proteins of the superfamily of “ubiguitin-like proteins”, proteins that have a ubiguitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention also relates to a method for the production and utilization of said proteins.
摘要翻译： 本发明涉及“ubiguitin样蛋白”的超家族的修饰蛋白质，具有ubiguitin样折叠的蛋白质及其片段或融合蛋白质。 作为所述修饰的结果，蛋白质相对于先前不存在的预定结合配偶体具有结合亲合力。 本发明还涉及生产和利用所述蛋白质的方法。
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公开(公告)号：US09492572B2
公开(公告)日：2016-11-15
申请号：US14126358
申请日：2012-06-15
IPC分类号： C07K19/00 , A61K51/08 , C12N1/14 , C12N15/62 , C12N15/63 , C12N1/16 , C12N1/20 , C07K14/47 , C07K14/00 , G01N33/68
CPC分类号： A61K51/08 , C07K14/00 , C07K14/47 , C07K2319/00 , C07K2319/33 , C07K2319/95 , C12N1/14 , C12N1/16 , C12N1/20 , C12N15/62 , C12N15/63 , G01N33/6803
摘要： The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合靶的修饰的泛素获得的新型二聚体蛋白质。 新型二聚结合蛋白包含氨基酸取代和至少一个氨基酸插入单体之一的组合。 本发明进一步涉及所述蛋白质在医学诊断或治疗方法中的用途。
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4.发明授权Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin 有权具有纤连蛋白外域B的特异性结合活性的修饰的泛素蛋白公开(公告)号：US08921304B2
公开(公告)日：2014-12-30
申请号：US13142195
申请日：2010-12-14
申请人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
发明人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
IPC分类号： A61K38/00 , C07K14/00 , C12N15/10 , C07K14/47 , C07K14/435 , C07K14/525 , G01N33/68
CPC分类号： C12N15/1034 , C07K14/435 , C07K14/47 , C07K14/525 , C07K2319/31 , C07K2319/95 , C12N15/1037 , C12N15/1041 , C12N15/1044 , G01N33/6845 , G01N33/6878
摘要： The present invention refers to novel hetero-multimeric proteins obtained from modified ubiquitin capable of binding the extradomain B of fibronectin (ED-B) with high affinity. Furthermore, the invention refers to fusion proteins comprising said recombinant protein fused to a pharmaceutically and/or diagnostically active component. The invention is further directed to the use of said proteins in medical treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合纤连蛋白（ED-B）的外域B的修饰的泛素获得的新型异多聚体蛋白。 此外，本发明涉及包含与药学和/或诊断活性成分融合的所述重组蛋白的融合蛋白。 本发明进一步涉及所述蛋白质在医疗处理方法中的用途。
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公开(公告)号：US20140127129A1
公开(公告)日：2014-05-08
申请号：US14126358
申请日：2012-06-15
CPC分类号： A61K51/08 , C07K14/00 , C07K14/47 , C07K2319/00 , C07K2319/33 , C07K2319/95 , C12N1/14 , C12N1/16 , C12N1/20 , C12N15/62 , C12N15/63 , G01N33/6803
摘要： The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合靶的修饰的泛素获得的新型二聚体蛋白质。 新型二聚结合蛋白包含氨基酸取代和至少一个氨基酸插入单体之一的组合。 本发明进一步涉及所述蛋白质在医学诊断或治疗方法中的用途。
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6.发明申请MODIFIED UBIQUITIN PROTEINS HAVING A SPECIFIC BINDING ACTIVITY FOR THE EXTRADOMAIN B OF FIBRONECTIN 有权具有特异性结合活性的修饰的UBIQUITIN蛋白对纤维蛋白的超量B公开(公告)号：US20130011334A1
公开(公告)日：2013-01-10
申请号：US13142195
申请日：2010-12-14
申请人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
发明人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
IPC分类号： A61K38/17 , A61K38/54 , C12Q1/02 , C12N9/96 , C07H21/04 , C12N15/63 , C40B40/08 , C40B40/10 , C40B50/00 , C07K14/435 , A61K51/08 , C12N1/21
CPC分类号： C12N15/1034 , C07K14/435 , C07K14/47 , C07K14/525 , C07K2319/31 , C07K2319/95 , C12N15/1037 , C12N15/1041 , C12N15/1044 , G01N33/6845 , G01N33/6878
摘要： The present invention refers to novel hetero-multimeric proteins obtained from modified ubiquitin capable of binding the extradomain B of fibronectin (ED-B) with high affinity. Furthermore, the invention refers to fusion proteins comprising said recombinant protein fused to a pharmaceutically and/or diagnostically active component. The invention is further directed to the use of said proteins in medical treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合纤连蛋白（ED-B）的外域B的修饰的泛素获得的新型异多聚体蛋白。 此外，本发明涉及包含与药学和/或诊断活性成分融合的所述重组蛋白的融合蛋白。 本发明进一步涉及所述蛋白质在医疗处理方法中的用途。
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7.发明授权公开(公告)号：US08790895B2
公开(公告)日：2014-07-29
申请号：US11283332
申请日：2005-11-18
申请人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
发明人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
CPC分类号： C12N15/1044 , C07K14/00 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6872
摘要： The invention relates to modified proteins of the superfamily of “ubiquitin-like proteins”, proteins that have a ubiquitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention also relates to a method for the production and utilization of said proteins.
摘要翻译： 本发明涉及“遍在蛋白样蛋白”的超家族的修饰蛋白质，具有泛素样折叠的蛋白质及其片段或融合蛋白质。 作为所述修饰的结果，蛋白质相对于先前不存在的预定结合配偶体具有结合亲合力。 本发明还涉及生产和利用所述蛋白质的方法。
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8.发明申请METHOD FOR IDENTIFYING HETERO-MULTIMERIC MODIFIED UBIQUITIN PROTEINS WITH BINDING CAPABILITY TO LIGANDS 有权用于鉴定具有结合能力的多态性修饰的UBIQUITIN蛋白的方法公开(公告)号：US20130157878A1
公开(公告)日：2013-06-20
申请号：US13144809
申请日：2010-12-14
申请人： Anja Kunert , Jörg Narkamp , Arnd Steuernagel , Markus Fiedler , Erik Fiedler , Thomas Göttler
发明人： Anja Kunert , Jörg Narkamp , Arnd Steuernagel , Markus Fiedler , Erik Fiedler , Thomas Göttler
CPC分类号： C12N15/1034 , C07K14/435 , C07K14/47 , C07K14/525 , C07K2319/31 , C07K2319/95 , C12N15/1037 , C12N15/1041 , C12N15/1044 , G01N33/6845 , G01N33/6878
摘要： The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a population of said hetero-multimeric ubiquitins as well as protein libraries obtained by expression of said DNA libraries, cells and phages containing said DNA or proteins, polynucleotides encoding for said fusion proteins and vectors comprising said polynucleotides. Further new binding proteins based on hetero-multimeric ubiquitin being able to bind specifically with high affinity to selected ligands are provided.
摘要翻译： 本发明涉及用于鉴定具有与配体结合能力的异源多聚体泛素的方法。 此外，本发明提供编码所述异多聚体泛素的群体的DNA文库以及通过表达所述DNA文库，含有所述DNA或蛋白质的细胞和噬菌体，编码所述融合蛋白的多核苷酸和包含所述多核苷酸的载体获得的蛋白质文库 。 提供了基于异多聚体泛素能够以高亲和力特异性结合所选择的配体的进一步的新结合蛋白。
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9.发明申请MODIFIED UBIQUITIN PROTEINS HAVING A SPECIFIC BINDING ACTIVITY FOR THE EXTRADOMAIN B OF FIBRONECTIN 审中-公开具有特异性结合活性的修饰的UBIQUITIN蛋白对纤维蛋白的超量B公开(公告)号：US20120301393A1
公开(公告)日：2012-11-29
申请号：US13516002
申请日：2010-12-14
申请人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
发明人： Arnd Steuernagel , Erik Fiedler , Markus Fiedler , Anja Kunert , Joerg Nerkamp , Thomas Goettler , Manja Gloser , Ilka Haenssgen
IPC分类号： A61K38/16 , C12N9/96 , A61K33/24 , G01N33/53 , C12N15/62 , C12N15/63 , C12N1/21 , A61P35/00 , C07K14/00 , A61K51/00
CPC分类号： C12N15/1034 , C07K14/435 , C07K14/47 , C07K14/525 , C07K2319/31 , C07K2319/95 , C12N15/1037 , C12N15/1041 , C12N15/1044 , G01N33/6845 , G01N33/6878
摘要： The present invention refers to novel recombinant proteins obtained from modified ubiquitin capable of binding the extradomain B of fibronectin (ED-B). Furthermore, the invention refers to fusion proteins comprising said recombinant protein fused to a pharmaceutically and/or diagnostically active component.
摘要翻译： 本发明涉及从能够结合纤连蛋白的外部区域B（ED-B）的修饰的泛素得到的新型重组蛋白质。 此外，本发明涉及包含与药学和/或诊断活性成分融合的所述重组蛋白的融合蛋白。
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公开(公告)号：US20100143387A1
公开(公告)日：2010-06-10
申请号：US12525902
申请日：2008-02-11
申请人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
发明人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
IPC分类号： A61K39/395 , C07D403/14 , C07C235/06 , C07K2/00 , C07K14/475 , C07H21/00 , C07K16/00 , A61K38/00 , A61K31/7088 , A61K31/4025 , A61K31/16
摘要： The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
摘要翻译： 本发明涉及由该多聚体试剂和生物活性剂形成的多聚体试剂和多聚体缀合物。 所述多聚体缀合物与未修饰的生物学试剂相比在体内具有更长的使用寿命和更高的亲合力。 本发明还涉及含有所述缀合物的药物或诊断组合物以及其制备方法。 本发明还提供所述缀合物用于特异性结合配偶体的检测，测定，分离和/或分离以及用于诊断，预防和治疗特异性结合配偶体直接或间接参与的疾病的用途。
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