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公开(公告)号：US08207147B2
公开(公告)日：2012-06-26
申请号：US10584025
申请日：2004-12-23
Applicant: Matthew Colin Thor Fyfe , Lisa Sarah Gardner , John King-Underwood , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Gerard Hugh Thomas
Inventor： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , John King-Underwood , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Gerard Hugh Thomas
IPC: A61K31/66 , A61K31/497 , A61K31/4523 , C07D401/14 , C07F9/02 , C07D211/00 , C07D413/14
CPC classification number: C07D413/14 , C07D401/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/14
Abstract: Compounds of Formula (I), R1-A-V—B—R2; or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.
Abstract translation: 式（I）的化合物，R1-A-V-B-R2; 或其药学上可接受的盐是GPR116的激动剂，并且可用作饱腹感的调节剂，例如， 用于治疗肥胖症和治疗糖尿病。
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公开(公告)号：US20110212939A1
公开(公告)日：2011-09-01
申请号：US13003571
申请日：2009-07-10
Applicant: Lisa Sarah Bertram , Philip Graham Clarke , Graham John Dawson , Peter Timothy Fry , Matthew Colin Thor Fyfe , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Thomas Martin Krulle , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Simon Andrew Swain
Inventor： Lisa Sarah Bertram , Philip Graham Clarke , Graham John Dawson , Peter Timothy Fry , Matthew Colin Thor Fyfe , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Thomas Martin Krulle , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Simon Andrew Swain
IPC: A61K31/397 , C07D401/04 , A61K31/506 , C07D401/14 , A61K31/4965 , A61K31/454 , A61K31/4725 , A61K31/4709 , A61K31/517 , A61P3/00
CPC classification number: C07D401/12 , C07D295/205 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR（GPR119）激动剂，可用于治疗糖尿病和肥胖症。
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公开(公告)号：US20090221824A1
公开(公告)日：2009-09-03
申请号：US11573471
申请日：2005-08-12
Applicant: Paul Howard Briner , Matthew Colin Thor Fyfe , John Paul Madeley , Peter John Murray , Martin James Procter , Felix Spindler
Inventor： Paul Howard Briner , Matthew Colin Thor Fyfe , John Paul Madeley , Peter John Murray , Martin James Procter , Felix Spindler
IPC: C07D405/12 , C07D315/00 , C07D417/12
CPC classification number: C07D405/12 , C07D309/04 , C07D417/12
Abstract: A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.
Abstract translation: 一种制备包含2-取代的丙烯酸衍生物的对映选择性氢化的化合物的方法。
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公开(公告)号：US20090221639A1
公开(公告)日：2009-09-03
申请号：US12225961
申请日：2007-04-05
Applicant: Lisa Sarah Bertram , Matthew Colin Thor Fyfe , Martin James Procter , Geoffrey Martyn Williams
Inventor： Lisa Sarah Bertram , Matthew Colin Thor Fyfe , Martin James Procter , Geoffrey Martyn Williams
IPC: A61K31/4545 , C07D413/02 , A61K31/454 , C07D401/02 , A61P3/04 , A61P3/10 , A61P3/00
CPC classification number: C07D413/14 , C07D413/12
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPR119的激动剂，可用作饱腹感调节剂，例如， 用于治疗肥胖症和治疗糖尿病。
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公开(公告)号：US20090203676A1
公开(公告)日：2009-08-13
申请号：US11922826
申请日：2006-06-30
Applicant: Oscar Barba , Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Simon Andrew Swain
Inventor： Oscar Barba , Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Simon Andrew Swain
IPC: A61K31/496 , C07D401/06 , C07D401/14 , C07D413/14 , C07D497/08 , A61K31/551 , A61K31/454 , A61P3/04 , A61P3/10 , A61P3/00
CPC classification number: C07D401/04 , C07D211/20 , C07D211/26 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D487/08
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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Patent Agency Ranking
公开(公告)号：US20080293741A1
公开(公告)日：2008-11-27
申请号：US12091320
申请日：2006-03-11
Applicant: Matthew Colin Thor Fyfe , Martin James Procter
Inventor： Matthew Colin Thor Fyfe , Martin James Procter
IPC: A61K31/495 , C07D241/20 , C07D213/72 , C07D261/14 , A61K31/426 , A61K31/505 , A61P3/10 , A61K31/42 , A61K31/44 , C07D277/38 , C07D239/42
CPC classification number: C07D241/20 , C07D213/75 , C07D239/42 , C07D261/14 , C07D277/46
Abstract: Compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 式（I）化合物：（I）或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US20080293730A1
公开(公告)日：2008-11-27
申请号：US12091376
申请日：2006-11-11
Applicant: Matthew Colin Thor Fyfe , Martin James Procter
Inventor： Matthew Colin Thor Fyfe , Martin James Procter
IPC: A61K31/501 , C07D241/02 , C07D239/02 , C07D405/02 , C07D261/14 , C07D277/18 , C07D403/02 , A61K31/497 , A61K31/506 , A61K31/4433 , A61K31/422 , A61K31/4178
CPC classification number: C07D309/06 , C07D405/12 , C07D413/12 , C07D417/12
Abstract: Compounds of Formula (I): (formula) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 式（I）化合物：（式）或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US07262196B2
公开(公告)日：2007-08-28
申请号：US10776559
申请日：2004-02-10
Applicant: Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Geoffrey Martyn Williams , David Witter , Arlindo Castelhano , Kosuke Yasuda
Inventor： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Geoffrey Martyn Williams , David Witter , Arlindo Castelhano , Kosuke Yasuda
IPC: A61K31/498 , A61K31/506 , C07D43/14
CPC classification number: C07D401/04 , C07D213/55 , C07D213/61 , C07D213/70 , C07D213/75 , C07D239/38 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts or N-oxides thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐或N-氧化物可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US20120214808A1
公开(公告)日：2012-08-23
申请号：US13399517
申请日：2012-02-17
Applicant: Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Simon Andrew Swain , Philippe Wong-Kai-In
Inventor： Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Simon Andrew Swain , Philippe Wong-Kai-In
IPC: A61K31/5377 , C07D277/38 , A61K31/381 , C07D333/50 , C07D333/36 , A61K31/17 , C07C275/42 , A61K31/4164 , C07D233/56 , A61K31/428 , C07D277/82 , A61K31/44 , C07D213/72 , A61K31/5375 , C07D295/12 , A61K31/505 , C07D239/02 , C07D413/04 , A61P3/04 , A61P25/18 , A61P25/24 , A61P3/00 , A61P25/08 , A61P25/00 , A61K31/426
CPC classification number: A61K31/381 , A61K31/341 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/455
Abstract: A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.
Abstract translation: 通过向需要这种治疗的受试者施用有效量的芳基脲CB-1受体调节化合物来治疗与CB-1受体相关的病症，特别是肥胖症的方法。
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公开(公告)号：US20110178054A1
公开(公告)日：2011-07-21
申请号：US13003573
申请日：2009-07-10
Applicant: Lisa Sarah Bertram , Matthew Colin Thor Fyfe , William Gattrell , Revathy P. Jeevaratnam , John Keily , Martin James Procter
Inventor： Lisa Sarah Bertram , Matthew Colin Thor Fyfe , William Gattrell , Revathy P. Jeevaratnam , John Keily , Martin James Procter
IPC: A61K31/454 , C07D413/04 , C07D413/14 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P3/00 , A61P3/06 , A61P9/12
CPC classification number: C07D413/04 , C07D413/14
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR（GPR119）激动剂，可用于治疗糖尿病和肥胖症。
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