公开(公告)号：US20130288922A1

公开(公告)日：2013-10-31

申请号：US13940011

申请日：2013-07-11

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Tim R. Mosmann ,  David Topham ,  Charles R. Mace

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  C12N2760/16011 ,  G01N21/05 ,  G01N21/211 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/1725 ,  G01N2021/558 ,  G01N2021/5957 ,  G01N2333/11 ,  G01N2800/52

Abstract: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.

公开(公告)号：US20130070201A1

公开(公告)日：2013-03-21

申请号：US13512218

申请日：2010-11-30

Applicant: Mahnaz Shahidi ,  Justin Wanek ,  Bruce Gaynes

Inventor： Mahnaz Shahidi ,  Justin Wanek ,  Bruce Gaynes

IPC: A61B3/14

CPC classification number: A61B3/14 ,  A61B3/10 ,  A61B3/1241 ,  A61B3/145 ,  A61B5/02007 ,  A61B5/026 ,  A61B5/113 ,  G01N2021/5957

Abstract: Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.

Abstract translation: 公开了定量测量体内血管直径，血液速度和其他流动动力学的方法和组合物。 这样的方法和组合物可以优化旨在预防或降低心血管和血液疾病风险的治疗干预措施。 在一个方面，所述方法和装置包括从受试者眼睛的结膜中的血管的二维图像计算血管特征。 在另一方面，获得血管的一系列时间图像以确定血流特性。 该装置可以包括例如生物显微镜，照明光源和高速相机，以便随后由编程的处理器分析的数据来获取一系列时间图像。

公开(公告)号：US07880885B1

公开(公告)日：2011-02-01

申请号：US12270611

申请日：2008-11-13

Applicant: James M. Stana ,  Ronald H. Gilmore ,  Kevin F. Williams

Inventor： James M. Stana ,  Ronald H. Gilmore ,  Kevin F. Williams

IPC: G01N21/00 ,  G01N21/55

CPC classification number: G01N21/958 ,  G01N21/94 ,  G01N2021/5915 ,  G01N2021/5957 ,  G01N2021/9586 ,  G01N2201/0221

Abstract: An apparatus and method for evaluating window transmission loss comprising taking a plurality of photographs through a filter of a window to be evaluated, determining a percentage of the window shown in each photograph that is undamaged, and computing an estimate of transmission loss for the window from the percentages determined.

Abstract translation: 一种用于评估窗口传输损耗的装置和方法，包括通过要评估的窗口的滤波器来获取多个照片，确定未损坏的每张照片中显示的窗口的百分比，以及计算窗口的传输损耗的估计值 确定百分比。

公开(公告)号：US20050225766A1

公开(公告)日：2005-10-13

申请号：US11130717

申请日：2005-05-17

Applicant: Frans Hansen ,  Martin Glensbjerg ,  Borkur Arnvidarson ,  Jesper Jeppesen

Inventor： Frans Hansen ,  Martin Glensbjerg ,  Borkur Arnvidarson ,  Jesper Jeppesen

IPC: G01N33/483 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/06 ,  G01N20060101 ,  G01N15/00 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14 ,  G01N21/00 ,  G01N21/49 ,  G01N21/59 ,  G01N21/64 ,  G01N21/65 ,  G01N24/00 ,  G01N24/08 ,  G01N27/12 ,  G01N33/04 ,  G01N33/48 ,  G01N33/487 ,  G06M11/00

CPC classification number: G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.

Abstract translation: 本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的来自样品的曝光区域电磁信号可以从该区域传播到外部，并将其暴露于诸如CCD元件的主动检测元件阵列上，空间 在从暴露期间通过检测元件阵列检测到的强度的处理条件下，可以通过各个有源检测元件检测作为强度的表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 液体样品的体积大小足够大以允许评估数量和质量参数以满足基于基本上一次暴露的评估的统计质量的预定要求。

公开(公告)号：US20050163354A1

公开(公告)日：2005-07-28

申请号：US10502137

申请日：2003-01-11

Applicant: Michael Ziegler

Inventor： Michael Ziegler

IPC: G01N15/05 ,  G01N21/59 ,  G01N21/88 ,  G01N21/90 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G06K9/00

CPC classification number: G01N35/00603 ,  G01N15/05 ,  G01N21/51 ,  G01N35/0092 ,  G01N35/026 ,  G01N35/10 ,  G01N2021/5923 ,  G01N2021/5957 ,  G01N2021/5973 ,  G01N2035/00504 ,  G01N2035/0406 ,  G01N2035/041 ,  G01N2035/0493

Abstract: The invention relates to a method and a device for analyzing body fluids (21). A picture recording device (30) is placed in a flare-free room (16) provided with a lighting equipment (45) and is connected to an electronic picture evaluating device. The picture recording device (30) is focused on a container (20) which is in an analysis position (22) and contains the body fluid (21) in order to take at least one picture of the body fluid (21). Said picture is analyzed by picture-evaluating software, whereby the quality and quantity of the body fluid (21) is detected.

Abstract translation: 本发明涉及一种用于分析体液（21）的方法和装置。 图像记录装置（30）被放置在设置有照明设备（45）的无闪光室（16）中并连接到电子图像评估装置。 图像记录装置（30）聚焦在处于分析位置（22）并容纳体液（21）的容器（20）上，以便取得体液（21）的至少一张照片。 所述图像由图像评估软件分析，由此检测体液（21）的质量和数量。

公开(公告)号：US06919960B2

公开(公告)日：2005-07-19

申请号：US10727832

申请日：2003-12-04

Applicant: Frans Ejner Rvan Hansen ,  Martin Glensbjerg ,  Borkur Arnvidarson ,  Jesper Myron Jeppesen

Inventor： Frans Ejner Rvan Hansen ,  Martin Glensbjerg ,  Borkur Arnvidarson ,  Jesper Myron Jeppesen

IPC: G01N33/483 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/06 ,  G01N20060101 ,  G01N15/00 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14 ,  G01N21/00 ,  G01N21/49 ,  G01N21/59 ,  G01N21/64 ,  G01N21/65 ,  G01N24/00 ,  G01N24/08 ,  G01N27/12 ,  G01N33/04 ,  G01N33/48 ,  G01N33/487 ,  G06M11/00

CPC classification number: G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.

公开(公告)号：US20040076325A1

公开(公告)日：2004-04-22

申请号：US10415986

申请日：2003-05-06

Inventor： Atsusi Wada ,  Kouji Egawa

IPC: G06K009/00

CPC classification number: G01N21/5907 ,  G01J1/124 ,  G01J1/1626 ,  G01N21/274 ,  G01N2021/5949 ,  G01N2021/5957

Abstract: A linearizing correction unit (104) carries out a linearizing correction process on the output of an image sensor (8) based upon linearizing correction data stored in a linearizing correction data holding unit (102), and a light-irregularity correction unit (108) carries out a light-irregularity correction process on the image sensor output that has been subjected to the linearizing correction process based upon light-irregularity correction data stored in a light-irregularity correction data holding unit (106). A refection factor calculation unit (110) calculates an integral value of the in-plane reflection factor of a test piece by using the output that has been subjected to the linearizing correction and light-irregularity correction with respect to pixel outputs of the image sensor (8) obtained when the test piece having in-plane density irregularities is measured. A quantifying unit (114) applies calibration curve data of a calibration-curve-data holding unit (112) to the integrated reflection factor obtained by the reflection factor calculation unit so that a sample density of the test piece is calculated.

Abstract translation: 线性化校正单元（104）基于线性化校正数据保存单元（102）中存储的校正数据和光不规则校正单元（108），对图像传感器（8）的输出执行线性化校正处理， 对已经经过线性化校正处理的图像传感器输出，基于存储在光不规则校正数据保持单元（106）中的光不规则校正数据执行光不规则校正处理。 反射因子计算单元（110）通过使用对图像传感器的像素输出进行线性化校正和光不规则校正的输出来计算测试片的面内反射系数的积分值（ 测量具有面内密度不均匀的试验片时获得的图8所示的结果。 量化单元（114）将校准曲线数据保持单元（112）的校准曲线数据应用于由反射因子计算单元获得的积分反射系数，从而计算出测试片的样本密度。

公开(公告)号：US20040034494A1

公开(公告)日：2004-02-19

申请号：US10415991

申请日：2003-05-06

Inventor： Atsusi Wada ,  Kouji Egawa

IPC: G01D018/00

CPC classification number: G01J1/1626 ,  G01J1/124 ,  G01N21/4738 ,  G01N21/59 ,  G01N2021/5949 ,  G01N2021/5957

Abstract: Above a measuring object (2), an LEDs (4) for use in light irradiation and a CMOS area sensor (8) with an image-forming lens (6) interpolated in between are installed. In order to detect the quantity of light from the LEDs (4), a photodetector (10) is further placed. A personal computer (28) carries out a linearizing process which, upon variation of the quantity of light, corrects the output of the area sensor (8) so as to make the output from the area sensor (8) proportional to the output of the photodetector (10), and a light-irregularity correction process which, when a flat plate having even in-plane density is measured as the measuring object (2), corrects the resulting output of each pixel in the area sensor (8) that has been corrected by the linearizing process to have in-plane evenness. It becomes possible to achieve a convenient two-dimensional reflection factor measuring method which does not need any mechanical driving system.

Abstract translation: 在测量对象（2）上方安装用于光照射的LED（4）和内置有图像形成透镜（6）的CMOS区域传感器（8）。 为了检测来自LED（4）的光量，进一步放置光电检测器（10）。 个人计算机（28）执行线性化处理，其在光量变化时校正区域传感器（8）的输出，以使区域传感器（8）的输出与 光检测器（10）和光不均匀性校正处理，当测量具有平面密度的平板作为测量对象（2）时，校正已经具有的区域传感器（8）中的每个像素的所得输出 通过线性化处理被校正为具有平面内均匀性。 可以实现不需要任何机械驱动系统的方便的二维反射因子测量方法。

公开(公告)号：US5337148A

公开(公告)日：1994-08-09

申请号：US952501

申请日：1992-12-02

Applicant: Nobutoshi Torii ,  Ryo Nihei ,  Hiroshi Wakio

Inventor： Nobutoshi Torii ,  Ryo Nihei ,  Hiroshi Wakio

IPC: B23K9/32 ,  B23K9/10 ,  G01J1/00 ,  G01J1/04 ,  G01J1/18 ,  G01J1/42 ,  G01N21/15 ,  G01N21/59

CPC classification number: G01J1/18 ,  B23K9/10 ,  G01N2021/157 ,  G01N2021/5957 ,  G01N2201/12753

Abstract: The purpose of the invention is to properly determine the replacement time of a guard window of an arc sensor using an original function of the arc sensor.The apparatus for monitoring a guard window of an arc sensor according to the present invention is provided with an arc sensor guard window (28) mounted on an arc sensor unit (20) and a standard reflecting plate (30) located at a position a determined distance from the front surface of the guard window (28). And the apparatus detects the reflected light (27) from the standard reflecting plate (30) when a laser beam (26) scans the standard reflecting plate (30), before the guard window (28) is used for an arc welding operation. The apparatus memorizes the quantity of detected light reception as the first quantity. The apparatus then detects the reflected light (27) from the standard reflecting plate (30) in the same way as before, after the guard window (28) is used for an arc welding operation. The apparatus memorizes the quantity of detected light reception as the second quantity of detected light reception as the second quantity. Based on the difference between the first quantity and the second quantity, the condition of the guard window (28) is checked and it is determined whether or not the guard window (28) should be replaced.

Abstract translation: PCT No.PCT / JP92 / 00409 Sec。 371日期1992年12月2日 102（e）日期1992年12月2日PCT提交1992年4月2日PCT公布。 出版物WO92 / 17754 日期为1992年10月15日。本发明的目的是使用电弧传感器的原始功能来适当地确定电弧传感器的防护窗的更换时间。 根据本发明的用于监测电弧传感器的防护窗的装置设置有安装在电弧传感器单元（20）和标准反射板（30）上的电弧传感器防护窗（28），该标准反射板位于确定的位置 距保护窗（28）前表面的距离。 并且当激光束（26）在保护窗（28）用于电弧焊接操作之前扫描标准反射板（30）时，该装置从标准反射板（30）检测反射光（27）。 该装置将检测到的光接收量存储为第一数量。 然后，在将防护窗（28）用于电弧焊接操作之后，装置以与之前相同的方式从标准反射板（30）检测反射光（27）。 该装置将检测到的光接收量作为第二数量存储为第二检测光接收量。 基于第一数量和第二数量之间的差异，检查保护窗（28）的状况，并确定是否应更换防护窗（28）。

公开(公告)号：US5309215A

公开(公告)日：1994-05-03

申请号：US894013

申请日：1992-06-05

Applicant: Matthias Schumann

Inventor： Matthias Schumann

IPC: G01N15/02 ,  G01N21/59 ,  G01N15/14

CPC classification number: G01N15/0227 ,  G01N2021/5957

Abstract: A method for automatic particle size analysis of a particle mixture by linear, optoelectronic scanning of a separated particle stream. Particle chord length categories are counted and converted to a particle size distribution. The method takes into account practical considerations such as mixed particle velocities and mixed grain shapes. The exposure time for the linear scanning determines, as a function of the diameter and the velocity of the smallest particle being measured, the number of particles per category size by means of appearance probabilities of recorded chord lengths for corresponding particle sizes. The determination of particle numbers is made using the sequence of the category of the largest particle diameters to the category of the smallest particle diameter, whereby, after each calculation of a particle size category, the number of chord lengths in the length category is corrected.

Abstract translation: 通过对分离的颗粒流的线性，光电扫描来对颗粒混合物进行自动粒度分析的方法。 颗粒和弦长度类别被计数并转换为粒度分布。 该方法考虑了诸如混合颗粒速度和混合颗粒形状的实际考虑。 线性扫描的曝光时间根据被测量的最小颗粒的直径和速度决定了每个类别尺寸的颗粒数，这是通过相应颗粒尺寸记录的和弦长度的外观概率来确定的。 颗粒数的确定使用最小粒径类别的序列与最小粒径的类别进行，由此，在每次计算粒度分类之后，校正长度类别中的弦长数量。