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1.发明申请Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物公开(公告)号：US20050070582A1
公开(公告)日：2005-03-31
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/18 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/437 , A61K31/4375 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/5375 , A61K31/551 , A61P5/16 , A61P9/10 , A61P11/02 , A61P11/06 , A61P25/28 , A61P27/16 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D209/44 , C07D211/14 , C07D211/26 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/12 , C07D295/13 , C07D295/194 , C07D295/22 , C07D295/26 , C07D307/14 , C07D333/38 , C07D333/40 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/44 , C07D213/62
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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2.发明授权Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders 有权用作CCR3拮抗剂治疗炎症和免疫疾病的芳基磺酰胺衍生物公开(公告)号：US08242118B2
公开(公告)日：2012-08-14
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/535 , A61K31/44 , A61K31/195 , A61K31/275 , A01N43/40 , A01N37/12 , A01N37/44 , A01N37/34 , C07D239/02 , C07D213/00 , C07C255/00 , C07C315/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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3.发明授权Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物公开(公告)号：US07700586B2
公开(公告)日：2010-04-20
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/55 , A01N43/62 , A61K31/497 , C07D243/08 , C07D241/04 , C07D295/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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4.发明申请ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS 有权用于治疗炎症和免疫疾病的CCR3拮抗剂的磺酰苯胺衍生物公开(公告)号：US20100204213A1
公开(公告)日：2010-08-12
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu LI , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Eukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu LI , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Eukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/551 , C07D241/04 , A61K31/495 , C07D403/12 , A61K31/496 , C07D243/08 , A61P25/28 , A61P19/02 , A61P11/06 , A61P9/10 , A61P31/18 , A61P11/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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5.发明授权公开(公告)号：US07375103B2
公开(公告)日：2008-05-20
申请号：US10508107
申请日：2003-03-03
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： C07D498/04 , A61K31/5365 , A61P29/00
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]恶嗪-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性
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6.发明申请公开(公告)号：US20050215547A1
公开(公告)日：2005-09-29
申请号：US10508107
申请日：2003-03-03
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： A47B23/00 , A47C21/00 , A61K31/5365 , A61P1/00 , A61P1/04 , A61P1/06 , A61P7/00 , A61P9/10 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D498/04 , A61K31/538 , C07D491/02
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]α-azin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]式（I）的α-氮杂环酮-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
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7.发明申请公开(公告)号：US20090054424A1
公开(公告)日：2009-02-26
申请号：US12123405
申请日：2008-05-19
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： A61K31/5365 , C12N9/99 , A61P35/00 , A61P37/06
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula: or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]恶嗪-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
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