-
1.发明授权Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders 有权用作CCR3拮抗剂治疗炎症和免疫疾病的芳基磺酰胺衍生物公开(公告)号：US08242118B2
公开(公告)日：2012-08-14
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/535 , A61K31/44 , A61K31/195 , A61K31/275 , A01N43/40 , A01N37/12 , A01N37/44 , A01N37/34 , C07D239/02 , C07D213/00 , C07C255/00 , C07C315/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
-
2.发明授权Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物公开(公告)号：US07700586B2
公开(公告)日：2010-04-20
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/55 , A01N43/62 , A61K31/497 , C07D243/08 , C07D241/04 , C07D295/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
-
3.发明申请ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS 有权用于治疗炎症和免疫疾病的CCR3拮抗剂的磺酰苯胺衍生物公开(公告)号：US20100204213A1
公开(公告)日：2010-08-12
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu LI , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Eukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu LI , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Eukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/551 , C07D241/04 , A61K31/495 , C07D403/12 , A61K31/496 , C07D243/08 , A61P25/28 , A61P19/02 , A61P11/06 , A61P9/10 , A61P31/18 , A61P11/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
-
4.发明申请Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物公开(公告)号：US20050070582A1
公开(公告)日：2005-03-31
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/18 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/437 , A61K31/4375 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/5375 , A61K31/551 , A61P5/16 , A61P9/10 , A61P11/02 , A61P11/06 , A61P25/28 , A61P27/16 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D209/44 , C07D211/14 , C07D211/26 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/12 , C07D295/13 , C07D295/194 , C07D295/22 , C07D295/26 , C07D307/14 , C07D333/38 , C07D333/40 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/44 , C07D213/62
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
-
5.发明申请公开(公告)号：US20090054424A1
公开(公告)日：2009-02-26
申请号：US12123405
申请日：2008-05-19
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： A61K31/5365 , C12N9/99 , A61P35/00 , A61P37/06
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula: or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]恶嗪-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
-
6.发明授权公开(公告)号：US07375103B2
公开(公告)日：2008-05-20
申请号：US10508107
申请日：2003-03-03
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： C07D498/04 , A61K31/5365 , A61P29/00
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]恶嗪-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性
-
7.发明申请公开(公告)号：US20050215547A1
公开(公告)日：2005-09-29
申请号：US10508107
申请日：2003-03-03
申请人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
发明人： Toshiki Murata , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Yuji Koriyama , Noriko Nunami , Megumi Yamauchi , Keiko Fukushima , Rolf Grosser , Kinji Fuchikami , Kevin Bacon , Timothy Lowinger
IPC分类号： A47B23/00 , A47C21/00 , A61K31/5365 , A61P1/00 , A61P1/04 , A61P1/06 , A61P7/00 , A61P9/10 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D498/04 , A61K31/538 , C07D491/02
CPC分类号： C07D498/04
摘要： An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]α-azin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 光学活性（ - ） - 7- [2-（环丙基甲氧基）-6-羟基苯基] -5 - [（3S）-3-哌啶基] -1,4-二氢-2H-吡啶并[2,3-d] 1,3]式（I）的α-氮杂环酮-2-酮或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
-
公开(公告)号：US07410986B2
公开(公告)日：2008-08-12
申请号：US10433377
申请日：2001-11-19
申请人： Toshiki Murata , Sachiko Sasaki , Takashi Yoshino , Yuka Ikegami , Tsutomu Masuda , Mitsuyuki Shimada , Takuya Shintani , Makoto Shimazaki , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Masaomi Umeda , Hiroshi Komura , Nagahiro Yoshida
发明人： Toshiki Murata , Sachiko Sasaki , Takashi Yoshino , Yuka Ikegami , Tsutomu Masuda , Mitsuyuki Shimada , Takuya Shintani , Makoto Shimazaki , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Masaomi Umeda , Hiroshi Komura , Nagahiro Yoshida
IPC分类号： A61K31/4412 , A61K31/4418 , C07D213/61 , C07D213/62
CPC分类号： C07D213/73 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/10 , C07D401/12 , C07D405/12
摘要： 4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6 alkyl, etc.; R4 is hydrogen, hydroxy, halogen, amino, etc.; R5 is hydroxy, amino, carboxy, etc.; R6 is hydrogen, carbamoyl, cyano, carboxy, C1-6 alkoxycarbonyl, etc. and R7 is amino or C1-6 alkanoylamino. The compounds (I) or the salts thereof have an excellent anti-inflammatory activity and the like.
摘要翻译： 通式为4-芳基嘧啶化合物及其盐：其中X为CH或N; R1是氢，卤素，C1-6烷基，C1-6烷氧基等; R2是氢或羟基; R3是氢，C1-6烷基等; R4是氢，羟基，卤素，氨基等; R5是羟基，氨基，羧基等; R6是氢，氨基甲酰基，氰基，羧基，C1-6烷氧基羰基等，R7是氨基或C1-6烷酰基氨基。 化合物（I）或其盐具有优异的抗炎活性等。
-
公开(公告)号：US06562811B1
公开(公告)日：2003-05-13
申请号：US09956618
申请日：2001-09-18
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K3154
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents hydrogen, —CR31R32R33, or —NR34R35; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 吡啶化合物，其通式如下：其中-R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基氨基，二（ C 1-6烷酰基氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯磺酰基氨基或-O-（CH 2）n -R 111; R2代表氢或卤素; R3表示氢，-CR31R32R33或-NR34R35; R4是氢，氨基甲酰基，CN，羧基等; R5是氨基，C1-6烷基氨基，二C1-6烷基氨基等或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
-
公开(公告)号：US06984649B1
公开(公告)日：2006-01-10
申请号：US10402500
申请日：2003-03-28
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4545 , C07D409/14 , C07D211/68 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents 1.2.3.6-tetrahydro-pyridine, or —CR31R32R33 wherein R31 represents H or C1-6 alkyl and R32 and R33 are joined to form a 5-8 membered saturated ring optionally containing up to three heteroatoms; R4 is carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译： 吡啶化合物，其通式如下：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基， （C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基， ，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示1.2.3.6-四氢 - 吡啶或-CR 31，其中R 1，R 2，R 3， SUP> 31表示H或C 1-6烷基，R 32和R 33连接形成5-8 任选地含有至多三个杂原子的饱和环; R 4是氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。 该化合物具有优异的抗炎活性和其他生物活性。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.055 秒)
