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公开(公告)号：US09345758B2
公开(公告)日：2016-05-24
申请号：US13066651
申请日：2011-04-19
申请人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , William L. Castleman , Nancy J. Cox
发明人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , William L. Castleman , Nancy J. Cox
IPC分类号： A61K39/145 , A61K39/12 , C12N15/86 , C07K14/005 , C12N7/00 , C07K16/10 , C12Q1/70 , G01N33/569 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12Q1/701 , G01N33/56983 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
摘要翻译： 本发明涉及能够感染犬只并引起犬瘟呼吸系统疾病的分离的流感病毒。 本发明还涉及用于诱导针对本发明的流感病毒的免疫应答的组合物和方法。 本发明还涉及用于鉴定本发明的病毒并用本发明的病毒诊断动物的感染的组合物和方法。
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公开(公告)号：US20110311586A1
公开(公告)日：2011-12-22
申请号：US13066651
申请日：2011-04-19
申请人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , William L. Castleman , Nancy J. Cox
发明人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , William L. Castleman , Nancy J. Cox
IPC分类号： A61K39/145 , C12N7/04 , C07H21/00 , A61P31/16 , C12N9/12 , C12N9/24 , A61P37/04 , C12N7/00 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12Q1/701 , G01N33/56983 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
摘要翻译： 本发明涉及能够感染犬只并引起犬瘟呼吸系统疾病的分离的流感病毒。 本发明还涉及用于诱导针对本发明的流感病毒的免疫应答的组合物和方法。 本发明还涉及用于鉴定本发明的病毒并用本发明的病毒诊断动物的感染的组合物和方法。
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公开(公告)号：US20110212126A1
公开(公告)日：2011-09-01
申请号：US13106053
申请日：2011-05-12
申请人： Frank Jay STERNER , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
发明人： Frank Jay STERNER , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
IPC分类号： A61K39/12 , A61K39/145 , A61K39/245 , A61P31/14 , A61P37/04
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55561 , C07K14/005 , C12N2770/24034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments of the present invention relate to methods of preventing and treating West Nile virus infection with the inactivated chimera or immunogenic composition.
摘要翻译： 本发明的实施方案提供了用于治疗或预防西尼罗河病毒感染的灭活嵌合病毒和免疫原性组合物。 此外，本发明的其它实施方案涉及用灭活的嵌合体或免疫原性组合物预防和治疗西尼罗河病毒感染的方法。
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4.发明授权Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome 失效在猪和疫苗中产生病变的高毒性猪繁殖和呼吸综合征病毒，可保护猪免受所述综合征
公开(公告)号：US5695766A
公开(公告)日：1997-12-09
申请号：US131625
申请日：1993-10-05
IPC分类号： G01N33/53 , A61K39/00 , A61K39/12 , A61P31/04 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/01 , C07K14/08 , C07K16/00 , C12N7/00 , C12N15/09 , C12N15/40 , C12P21/02 , C12P21/08 , G01N33/569 , A61K39/145 , C12N7/02 , C12N7/06 , C12N7/08
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , G01N33/56983 , A61K2039/5254 , A61K2039/543 , A61K2039/552 , A61K39/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , Y10S424/815
摘要： The present invention provides a vaccine which protects pigs from a virus and/or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and/or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and/or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and/or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and/or infectious agent which causes a porcine respiratory and reproductive disease.
摘要翻译： 本发明提供了一种保护猪免受引起猪呼吸和生殖疾病的病毒和/或感染因子的疫苗，一种保护猪免受由病毒引起的疾病和/或传染性疾病引起呼吸和 生殖疾病，产生针对病毒和/或引起猪繁殖和呼吸系统疾病的感染性疾病的疫苗的方法，以及与猪呼吸和生殖疾病相关的病毒和/或感染因子的生物学纯样本，特别是 猪繁殖和呼吸综合征病毒（PRRSV）的衣阿华菌株和与从引起猪呼吸和生殖疾病的病毒和/或感染因子的基因组获得的多核苷酸至少90％同源的分离的多核苷酸。
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公开(公告)号：US08133712B2
公开(公告)日：2012-03-13
申请号：US13106053
申请日：2011-05-12
申请人： Frank J. Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
发明人： Frank J. Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
IPC分类号： C12N7/00 , A61K39/12 , A61K39/295
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55561 , C07K14/005 , C12N2770/24034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments of the present invention relate to methods of preventing and treating West Nile virus infection with the inactivated chimera or immunogenic composition.
摘要翻译： 本发明的实施方案提供了用于治疗或预防西尼罗河病毒感染的灭活嵌合病毒和免疫原性组合物。 此外，本发明的其它实施方案涉及用灭活的嵌合体或免疫原性组合物预防和治疗西尼罗河病毒感染的方法。
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公开(公告)号：US08048429B2
公开(公告)日：2011-11-01
申请号：US11473600
申请日：2006-06-23
申请人： Frank Jay Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
发明人： Frank Jay Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
IPC分类号： A61K39/295 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55561 , C07K14/005 , C12N2770/24034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Embodiments of the present invention generally provide an inactivated chimeric virus vaccine and/or immunogenic composition for the treatment or prevention of viral infection. Further, various other embodiments of the present invention generally relate to methods of preventing and treating virus infection in such animals with the inactivated vaccine and/or immunogenic composition. Other embodiments comprise methods of preparing a vaccine or immunogenic composition for the treatment or prevention of viral infection in such animals.
摘要翻译： 本发明的实施方案通常提供用于治疗或预防病毒感染的灭活的嵌合病毒疫苗和/或免疫原性组合物。 此外，本发明的各种其它实施方案一般涉及用灭活的疫苗和/或免疫原性组合物预防和治疗这些动物中的病毒感染的方法。 其他实施方案包括制备用于治疗或预防这些动物中的病毒感染的疫苗或免疫原性组合物的方法。
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公开(公告)号：US20090246223A1
公开(公告)日：2009-10-01
申请号：US12392226
申请日：2009-02-25
申请人： Frank Jay Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
发明人： Frank Jay Sterner , Daniel Ghislena Emiel Goovaerts , Melissa Anne Lum , Mark William Mellencamp
IPC分类号： A61K39/295 , A61K39/12 , A61P37/04
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55561 , C07K14/005 , C12N2770/24034 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要： Embodiments of the present invention generally provide an inactivated chimeric virus vaccine and/or immunogenic composition for the treatment or prevention of viral infection. Further, various other embodiments of the present invention generally relate to methods of preventing and treating virus infection in such animals with the inactivated vaccine and/or immunogenic composition. Other embodiments comprise methods of preparing a vaccine or immunogenic composition for the treatment or prevention of viral infection in such animals.
摘要翻译： 本发明的实施方案通常提供用于治疗或预防病毒感染的灭活的嵌合病毒疫苗和/或免疫原性组合物。 此外，本发明的各种其它实施方案一般涉及用灭活的疫苗和/或免疫原性组合物预防和治疗这些动物中的病毒感染的方法。 其他实施方案包括制备用于治疗或预防这些动物中的病毒感染的疫苗或免疫原性组合物的方法。
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8.发明授权Method of producing a vaccine which raises an immunological response against a virus causing a porcine respiratory and reproductive disease 失效生产疫苗的方法，其提高针对导致猪呼吸和生殖疾病的病毒的免疫应答公开(公告)号：US06251404B1
公开(公告)日：2001-06-26
申请号：US08855526
申请日：1997-05-13
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/552 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , G01N33/56983 , Y10S424/815
摘要： The present invention provides a vaccine which protects pigs from a virus and/or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and/or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and/or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and/or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and/or infectious agent which causes a porcine respiratory and reproductive disease.
摘要翻译： 本发明提供了一种保护猪免受引起猪呼吸和生殖疾病的病毒和/或感染因子的疫苗，一种保护猪免受由病毒引起的疾病和/或传染性疾病引起呼吸和 生殖疾病，产生针对病毒和/或引起猪繁殖和呼吸系统疾病的感染性疾病的疫苗的方法，以及与猪呼吸和生殖疾病相关的病毒和/或感染因子的生物学纯样本，特别是 猪繁殖和呼吸综合征病毒（PRRSV）的衣阿华菌株和与从引起猪呼吸和生殖疾病的病毒和/或感染因子的基因组获得的多核苷酸至少90％同源的分离的多核苷酸。
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公开(公告)号：US20080075736A1
公开(公告)日：2008-03-27
申请号：US11584818
申请日：2006-10-19
申请人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox
发明人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox
IPC分类号： A61K39/145 , A61P31/16 , C07H21/00 , C07K16/08 , C07K2/00 , C12N5/16 , C12N7/00 , C12N7/04 , C12Q1/70 , G01N33/53
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12Q1/701 , G01N33/56983 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
摘要翻译： 本发明涉及能够感染犬只并引起犬瘟呼吸系统疾病的分离的流感病毒。 本发明还涉及用于诱导针对本发明的流感病毒的免疫应答的组合物和方法。 本发明还涉及用于鉴定本发明的病毒并用本发明的病毒诊断动物的感染的组合物和方法。
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10.发明授权
公开(公告)号：US6110467A
公开(公告)日：2000-08-29
申请号：US855531
申请日：1997-05-13
IPC分类号： G01N33/53 , A61K39/00 , A61K39/12 , A61P31/04 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/01 , C07K14/08 , C07K16/00 , C12N7/00 , C12N15/09 , C12N15/40 , C12P21/02 , C12P21/08 , G01N33/569 , A61K39/145 , C12N7/02 , C12N7/06 , C12N7/08
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , G01N33/56983 , A61K2039/522 , A61K39/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , Y10S424/815
摘要： The present invention provides a vaccine which protects pigs from a virus and/or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and/or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and/or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and/or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and/or infectious agent which causes a porcine respiratory and reproductive disease.
摘要翻译： 本发明提供了一种保护猪免受引起猪呼吸和生殖疾病的病毒和/或感染因子的疫苗，一种保护猪免受由病毒引起的疾病和/或传染性疾病引起呼吸和 生殖疾病，产生针对病毒和/或引起猪繁殖和呼吸系统疾病的感染性疾病的疫苗的方法，以及与猪呼吸和生殖疾病相关的病毒和/或感染因子的生物学纯样本，特别是 猪繁殖和呼吸综合征病毒（PRRSV）的衣阿华菌株和与从引起猪呼吸和生殖疾病的病毒和/或感染因子的基因组获得的多核苷酸至少90％同源的分离的多核苷酸。
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