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15 条记录 (耗时 0.029 秒)

    Thio-substituted arylmethanesulfinyl derivatives
    4.
    发明授权
    Thio-substituted arylmethanesulfinyl derivatives 有权
    硫代取代的芳基甲亚磺酰基衍生物

    公开(公告)号：US07297817B2

    公开(公告)日：2007-11-20

    申请号：US11104074

    申请日：2005-04-12

    申请人： Brigitte Lesur ,  Philippe Louvet ,  Rabindranath Tripathy

    发明人： Brigitte Lesur ,  Philippe Louvet ,  Rabindranath Tripathy

    IPC分类号： C07C233/05 ,  A61K31/18

    CPC分类号： C07C323/52 ,  C07C317/18 ,  C07C317/44 ,  C07C323/07 ,  C07C323/16 ,  C07C323/60 ,  C07C323/65 ,  C07D295/15 ,  C07D295/185 ,  C07D295/205 ,  C07D307/46 ,  C07D333/20

    摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R1, R2, R3, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

    摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及式（A）化合物的组合物：其中Ar，X，Y，R 1，R 2，R 3， SUP>和q如本文所定义; 以及它们在治疗疾病中的用途，包括治疗嗜睡，促进觉醒，治疗帕金森病，脑缺血，中风，睡眠呼吸暂停，进食障碍，刺激食欲和体重增加，治疗注意力缺陷多动障碍（“ADHD “），增强与大脑皮层功能低下相关疾病的功能，包括但不限于抑郁症，精神分裂症，疲劳，特别是与神经系统疾病如多发性硬化，慢性疲劳综合征和认知功能改善有关的疲劳 功能障碍。

    Thio-substituted arylmethanesulfinyl derivatives
    5.
    发明授权
    Thio-substituted arylmethanesulfinyl derivatives 有权
    硫代取代的芳基甲亚磺酰基衍生物

    公开(公告)号：US08071604B2

    公开(公告)日：2011-12-06

    申请号：US11983237

    申请日：2007-11-08

    申请人： Brigitte Lesur ,  Philippe Louvet ,  Rabindranath Tripathy

    发明人： Brigitte Lesur ,  Philippe Louvet ,  Rabindranath Tripathy

    IPC分类号： A61K31/4965 ,  A61K31/445 ,  A61K31/40 ,  C07D241/04 ,  C07D211/60 ,  C07D207/04 ,  C07C317/10

    CPC分类号： C07C323/65 ,  C07C317/18 ,  C07C317/44 ,  C07C323/16 ,  C07C323/60 ,  C07D295/15 ,  C07D295/185 ,  C07D307/46 ,  C07D333/20

    摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R1, R2, R3, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

    摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及式（A）化合物的组合物：其中Ar，X，Y，R 1，R 2，R 3和q如本文所定义; 以及它们在治疗疾病中的用途，包括治疗嗜睡，促进觉醒，治疗帕金森病，脑缺血，中风，睡眠呼吸暂停，进食障碍，刺激食欲和体重增加，治疗注意力缺陷多动障碍（“ADHD “），增强与大脑皮层功能低下相关疾病的功能，包括但不限于抑郁症，精神分裂症，疲劳，特别是与神经系统疾病如多发性硬化，慢性疲劳综合征和认知功能改善有关的疲劳 功能障碍。

    Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
    10.
    发明授权
    Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation 失效
    通过不对称氧化对映选择性合成硫代取代的芳基甲亚磺酰基衍生物的单一对映异构体的方法

    公开(公告)号：US08183294B2

    公开(公告)日：2012-05-22

    申请号：US12984279

    申请日：2011-01-04

    申请人： Philippe Louvet ,  Dominique Schweizer

    发明人： Philippe Louvet ,  Dominique Schweizer

    IPC分类号： A61K31/165 ,  C07C323/29

    CPC分类号： C07C315/02 ,  C07B2200/07 ,  C07C317/44

    摘要： The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.

    摘要翻译： 本发明涉及制备式（I）的亚砜化合物作为单一对映异构体或以对映异构体富集形式的方法，其包括以下步骤：a）使式（II）的前手性硫化物与金属手性 络合物，碱和氧化剂; 和任选地b）分离得到的式（I）的亚砜。 其中Ar，Y，R 1如权利要求1中所定义。