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    SELF-REPLICATING MATERIALS
    4.
    发明申请
    SELF-REPLICATING MATERIALS 有权
    自我更换材料

    公开(公告)号：US20100090180A1

    公开(公告)日：2010-04-15

    申请号：US12482823

    申请日：2009-06-11

    申请人： PAUL MICHAEL CHAIKIN ,  DAVID PINE ,  NADRIAN C. SEEMAN ,  DAVID G. GRIER

    发明人： PAUL MICHAEL CHAIKIN ,  DAVID PINE ,  NADRIAN C. SEEMAN ,  DAVID G. GRIER

    IPC分类号： G02F1/361 ,  C09K3/00

    CPC分类号： C12Q1/682 ,  B82Y5/00 ,  B82Y20/00 ,  C12N15/10 ,  C12N15/1031 ,  C12N15/1068 ,  C12Q2563/155 ,  C12Q2565/113

    摘要： The invention provides micron and sub-micron scale particles designed to recognize and selectively interact with each other by exploiting the recognition and specificity enabled by DNA-sequence-encoded coatings. Such materials possess sufficient information coded in their chemical and physical interactions to self assemble and self replicate. The invention further provides methods of using such materials to create self replicating and organizing materials. Replicated copies are permanently linked and then thermally detached, freeing them to act as templates for further growth. This new class of condensed matter systems, provides means to design and control the structure and function of materials and machines from the microscopic to life-size. In another aspect of the invention, depletion type forces and depletion zones can be utilized in the implementation of the self assembly and self replication of materials, including without limitation colloidal particles. The invention further provides novel means of synthesis and materials built by such synthesis, which may be used in a variety of applications, including microelectronics.

    摘要翻译： 本发明提供通过利用由DNA序列编码的涂层实现的识别和特异性来设计用于识别和选择性相互作用的微米级和亚微米级粒子。 这样的材料具有足够的信息，以其化学和物理相互作用编码，以自组装和自我复制。 本发明还提供了使用这种材料来创建自我复制和组织材料的方法。 复制副本永久链接，然后热分离，释放它们作为进一步增长的模板。 这种新型凝结物系统，提供了从微观到真实尺寸的材料和机器的结构和功能的设计和控制的手段。 在本发明的另一方面，耗尽型力和耗尽区可以用于实现材料的自组装和自我复制，包括但不限于胶体颗粒。 本发明还提供了新的合成方法和通过这种合成制备的材料，其可以用于包括微电子学在内的各种应用中。

    Nucleic acid based nano-robotic system
    7.
    发明授权
    Nucleic acid based nano-robotic system 有权
    基于核酸的纳米机器人系统

    公开(公告)号：US07163794B2

    公开(公告)日：2007-01-16

    申请号：US10962995

    申请日：2004-10-13

    申请人： William B. Sherman ,  Nadrian C. Seeman

    发明人： William B. Sherman ,  Nadrian C. Seeman

    IPC分类号： C12Q1/68 ,  C12M1/00 ,  G01N15/06 ,  C07H21/04

    CPC分类号： B82Y30/00

    摘要： A multiped, capable of traveling in more than one direction along a molecular path in a nano-robotic system where the steps taken by the feet of the multiped are controlled in a sequence specific fashion, is presented. The feet of the multiped dock to footholds on the molecular path via cohesion with “set” molecules and are released from the footholds through the introduction of “unset” molecules that detach or strip away the “set” molecules.

    摘要翻译： 提出了能够沿着纳米机器人系统中的分子路径在多于一个方向上行进的乘法器，其中乘法器的脚采取的步骤以顺序特定的方式被控制。 多功能码头的脚通过与“固定”分子的内聚力在分子路径上立足，并通过引入分离或剥离“组合”分子的“未设定”分子从足底释放。

    Construction of geometrical objects from polynucleotides
    8.
    发明授权
    Construction of geometrical objects from polynucleotides 失效
    从多核苷酸构建几何物体

    公开(公告)号：US5468851A

    公开(公告)日：1995-11-21

    申请号：US114301

    申请日：1993-09-02

    申请人： Nadrian C. Seeman ,  Yuwen Zhang

    发明人： Nadrian C. Seeman ,  Yuwen Zhang

    IPC分类号： C12N15/10 ,  C07H21/04

    CPC分类号： C12N15/10 ,  Y10S977/795

    摘要： One, two and three dimensional structures may be synthesized or modified from polynucleotides. A core structure is expanded by cleavage of a loop with a restriction endonuclease and ligating another polynucleotide to the sticky ends so that the recognition site of the restriction enzyme is not reformed. This process is repeated as many times as necessary to synthesize any desired structure. The structures formed have a wide range of uses.

    摘要翻译： 可以从多核苷酸合成或修饰一个，两个和三维结构。 通过用限制性内切核酸酶切割环并将另一多核苷酸连接到粘性末端来扩展核心结构，使得限制酶的识别位点不被重整。 根据需要重复该过程多次以合成任何所需的结构。 形成的结构具有广泛的用途。

    Construction of geometrical objects from polynucleotides
    9.
    发明授权
    Construction of geometrical objects from polynucleotides 失效
    从多核苷酸构建几何物体

    公开(公告)号：US5278051A

    公开(公告)日：1994-01-11

    申请号：US805564

    申请日：1991-12-12

    申请人： Nadrian C. Seeman ,  Yuwen Zhang

    发明人： Nadrian C. Seeman ,  Yuwen Zhang

    IPC分类号： C12N15/10

    CPC分类号： C12N15/10 ,  Y10S977/795

    摘要： One, two and three dimensional structures may be synthesized or modified from polynucleotides. A core structure is expanded by cleavage of a loop with a restriction endonuclease and ligating another polynucleotide to the sticky ends so that the recognition site of the restriction enzyme is not reformed. This process is repeated as many times as necessary to synthesize any desired structure. The structures formed have a wide range of uses.

    摘要翻译： 可以从多核苷酸合成或修饰一个，两个和三维结构。 通过用限制性内切核酸酶切割环并将另一多核苷酸连接到粘性末端来扩展核心结构，使得限制酶的识别位点不被重整。 根据需要重复该过程多次以合成任何所需的结构。 形成的结构具有广泛的用途。