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    Blending Mobile Search Results
    2.
    发明申请
    Blending Mobile Search Results 有权
    混合移动搜索结果

    公开(公告)号：US20110213772A1

    公开(公告)日：2011-09-01

    申请号：US13105750

    申请日：2011-05-11

    申请人： Ning Hu ,  Vida U. Ha

    发明人： Ning Hu ,  Vida U. Ha

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3053 ,  G06F17/30864 ,  G06F17/30867

    摘要： Methods, systems, and apparatus, including computer program products, for blending mobile search results. A method includes receiving a search query and multiple search results. The search results each satisfy the search query and have a respective search result quality score. The search results include generic and mobile search results. The generic and mobile search results each identify a generic and mobile resource, respectively. The search result quality scores include mobile and generic search result quality scores for the mobile and generic search results, respectively. The mobile search result quality scores and the generic search result quality scores were generated according to different scoring formulas. Based on one or more terms in the search query, the search query is classified as a mobile query. As a consequence, one or more search result quality scores are modified to improve the sorting of search results that include both mobile and generic search results.

    摘要翻译： 方法，系统和设备，包括用于混合移动搜索结果的计算机程序产品。 一种方法包括接收搜索查询和多个搜索结果。 搜索结果各自满足搜索查询并具有相应的搜索结果质量得分。 搜索结果包括通用和移动搜索结果。 通用和移动搜索结果各自分别标识通用和移动资源。 搜索结果质量得分分别包括移动和通用搜索结果的移动和一般搜索结果质量得分。 根据不同的评分公式生成移动搜索结果质量得分和通用搜索结果质量得分。 基于搜索查询中的一个或多个术语，搜索查询被分类为移动查询。 因此，修改一个或多个搜索结果质量得分以改进包括移动和一般搜索结果的搜索结果的排序。

    Method of drug loading in liposomes by gradient
    3.
    发明申请
    Method of drug loading in liposomes by gradient 审中-公开
    通过梯度在脂质体中加载药物的方法

    公开(公告)号：US20100119590A1

    公开(公告)日：2010-05-13

    申请号：US12501606

    申请日：2009-07-13

    申请人： Ning Hu ,  Gerard M. Jensen ,  Michele Sulivan ,  Stephanie Yang

    发明人： Ning Hu ,  Gerard M. Jensen ,  Michele Sulivan ,  Stephanie Yang

    IPC分类号： A61K9/127 ,  A61K31/55 ,  A61P35/00

    CPC分类号： A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K31/137 ,  A61K31/55 ,  A61K31/704

    摘要： A method for encapsulation of pharmaceutical agents (e.g., antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is base permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The stability of both the liposome and the pharmaceutical agent is thus maintained, prior to administration. The pH gradient is, however, present when the liposome is administered in vivo because the quenching agent rapidly exits the liposome.

    摘要翻译： 提供了在脂质体中封装药物（例如抗肿瘤剂）的方法，其优选具有高的药物：脂质比。 可以通过使用跨膜pH梯度的活性机制加载药物的方法制备脂质体。 使用这种技术，捕获效率接近100％。 药物：使用的脂质比例高于较老的传统脂质体制剂，并且药物从脂质体的释放速率降低。 加载后，残留的酸用低温基本可渗透的淬火剂骤冷。 残留的酸性因此降低，并且化学稳定性（例如抗水解）得到增强。 因此在施用之前维持脂质体和药剂的稳定性。 然而，当脂质体在体内施用时，pH梯度存在，因为猝灭剂快速离开脂质体。

    LIPID-BASED DISPERSIONS USEFUL FOR DRUG DELIVERY
    4.
    发明申请
    LIPID-BASED DISPERSIONS USEFUL FOR DRUG DELIVERY 审中-公开
    用于药物递送的基于脂质的分散剂

    公开(公告)号：US20090060998A1

    公开(公告)日：2009-03-05

    申请号：US10585915

    申请日：2005-01-14

    申请人： Ning Hu ,  Gerard M. Jensen ,  Stephanie Yang ,  Chiang Su-Ming

    发明人： Ning Hu ,  Gerard M. Jensen ,  Stephanie Yang ,  Chiang Su-Ming

    IPC分类号： A61K9/10

    CPC分类号： A61K9/127 ,  A61K9/0019

    摘要： The invention provides lipid-based dispersion comprising, a) phosphatidyl choline; b) an anionic phospholipid; optionally c) up to 1% cholesterol by weight of total lipids; and optionally d) a therapeutic agent; wherein the mean particle size measured by dynamic light scattering is less than 100 nm. The invention also provides pharmaceutical compositions comprising such a dispersion as well as methods of producing a therapeutic effect in a mammal comprising administering an effective amount of such a dispersion.

    摘要翻译： 本发明提供了脂质基分散体，其包含：a）磷脂酰胆碱; b）阴离子磷脂; 任选地c）总脂质重量高达1％的胆固醇; 和任选地d）治疗剂; 其中通过动态光散射测量的平均粒度小于100nm。 本发明还提供包含这种分散体的药物组合物以及在哺乳动物中产生治疗效果的方法，包括施用有效量的这种分散体。

    Epidermal melanocyte culture formulations
    6.
    发明授权
    Epidermal melanocyte culture formulations 失效
    表皮黑素细胞培养制剂

    公开(公告)号：US07132279B2

    公开(公告)日：2006-11-07

    申请号：US11190631

    申请日：2005-07-26

    申请人： Dan-Ning Hu ,  Steven McCormick

    发明人： Dan-Ning Hu ,  Steven McCormick

    IPC分类号： C12N5/00 ,  C12N5/02 ,  A01N63/00 ,  A01N65/00

    CPC分类号： C12N5/0626 ,  A61K35/12 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/12 ,  C12N2501/15

    摘要： The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of epidermal melanocytes that exhibit growth, migration and melanin production. The invention is based on the discovery of a culture medium composed of natural components, for culturing epidermal melanocytes that exhibit increased proliferative capacity, migratory behaviors and melanin production. The invention provides novel in vitro methods for culturing epidermal melanocytes, including those isolated from the skin of a healthy subject, to generate a proliferating population of epidermal melanocytes. The methods and compositions of the invention may be used for transplantation to treat patients having hypopigmentation or depigmentation skin disorders.

    摘要翻译： 本发明提供了用于向移植受体提供表皮黑素细胞的方法和组合物。 具体来说，本发明的方法和组合物提供可以从患者中分离并在体外培养的表皮黑素细胞群体，以产生表现出生长，迁移和黑色素生成的表皮黑素细胞增殖群体。 本发明基于由天然成分组成的培养基的发现，用于培养表现出增殖能力增加的表皮黑素细胞，迁移行为和黑色素生成。 本发明提供了用于培养表皮黑素细胞的新颖的体外方法，包括从健康受试者的皮肤分离的那些，以产生增殖的表皮黑素细胞群体。 本发明的方法和组合物可用于移植以治疗色素沉着过度或色素沉着失调的患者。

    Epidermal melanocyte culture formulations
    7.
    发明授权
    Epidermal melanocyte culture formulations 失效
    表皮黑素细胞培养制剂

    公开(公告)号：US06943024B2

    公开(公告)日：2005-09-13

    申请号：US10670971

    申请日：2003-09-24

    申请人： Dan-Ning Hu ,  Steven McCormick

    发明人： Dan-Ning Hu ,  Steven McCormick

    IPC分类号： A01N63/00 ,  A61K35/12 ,  A61K45/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071

    CPC分类号： C12N5/0626 ,  A61K35/12 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/12 ,  C12N2501/15

    摘要： The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of epidermal melanocytes that exhibit growth, migration and melanin production. The invention is based on the discovery of a culture medium composed of natural components, for culturing epidermal melanocytes that exhibit increased proliferative capacity, migratory behaviors and melanin production. The invention provides novel in vitro methods for culturing epidermal melanocytes, including those isolated from the skin of a healthy subject, to generate a proliferating population of epidermal melanocytes. The methods and compositions of the invention may be used for transplantation to treat patients having hypopigmentation or depigmentation skin disorders.

    摘要翻译： 本发明提供了用于向移植受体提供表皮黑素细胞的方法和组合物。 具体来说，本发明的方法和组合物提供可以从患者中分离并在体外培养的表皮黑素细胞群体，以产生表现出生长，迁移和黑色素生成的表皮黑素细胞增殖群体。 本发明基于由天然成分组成的培养基的发现，用于培养表现出增殖能力增加的表皮黑素细胞，迁移行为和黑色素生成。 本发明提供了用于培养表皮黑素细胞的新颖的体外方法，包括从健康受试者的皮肤分离的那些，以产生增殖的表皮黑素细胞群体。 本发明的方法和组合物可用于移植以治疗色素沉着过度或色素沉着失调的患者。

    Blending mobile search results
    9.
    发明授权
    Blending mobile search results 有权
    混合移动搜索结果

    公开(公告)号：US07962477B2

    公开(公告)日：2011-06-14

    申请号：US12019486

    申请日：2008-01-24

    申请人： Ning Hu ,  Vida U. Ha

    发明人： Ning Hu ,  Vida U. Ha

    IPC分类号： G06F7/00

    CPC分类号： G06F17/3053 ,  G06F17/30864 ,  G06F17/30867

    摘要： Methods, systems, and apparatus, including computer program products, for blending mobile search results. A method includes receiving a search query and multiple search results. The search results each satisfy the search query and have a respective search result quality score. The search results include generic and mobile search results. The generic and mobile search results each identify a generic and mobile resource, respectively. The search result quality scores include mobile and generic search result quality scores for the mobile and generic search results, respectively. The mobile search result quality scores and the generic search result quality scores were generated according to different scoring formulas. Based on one or more terms in the search query, the search query is classified as a mobile query. As a consequence, one or more search result quality scores are modified to improve the sorting of search results that include both mobile and generic search results.

    摘要翻译： 方法，系统和设备，包括用于混合移动搜索结果的计算机程序产品。 一种方法包括接收搜索查询和多个搜索结果。 搜索结果各自满足搜索查询并具有相应的搜索结果质量得分。 搜索结果包括通用和移动搜索结果。 通用和移动搜索结果各自分别标识通用和移动资源。 搜索结果质量得分分别包括移动和通用搜索结果的移动和一般搜索结果质量得分。 根据不同的评分公式生成移动搜索结果质量得分和通用搜索结果质量得分。 基于搜索查询中的一个或多个术语，搜索查询被分类为移动查询。 因此，修改一个或多个搜索结果质量得分以改进包括移动和一般搜索结果的搜索结果的排序。

    BLENDING MOBILE SEARCH RESULTS
    10.
    发明申请
    BLENDING MOBILE SEARCH RESULTS 有权
    混合移动搜索结果

    公开(公告)号：US20080183699A1

    公开(公告)日：2008-07-31

    申请号：US12019486

    申请日：2008-01-24

    申请人： Ning Hu ,  Vida U. Ha

    发明人： Ning Hu ,  Vida U. Ha

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3053 ,  G06F17/30864 ,  G06F17/30867

    摘要： Methods, systems, and apparatus, including computer program products, for blending mobile search results. A method includes receiving a search query and multiple search results. The search results each satisfy the search query and have a respective search result quality score. The search results include generic and mobile search results. The generic and mobile search results each identify a generic and mobile resource, respectively. The search result quality scores include mobile and generic search result quality scores for the mobile and generic search results, respectively. The mobile search result quality scores and the generic search result quality scores were generated according to different scoring formulas. Based on one or more terms in the search query, the search query is classified as a mobile query. As a consequence, one or more search result quality scores are modified to improve the sorting of search results that include both mobile and generic search results.

    摘要翻译： 方法，系统和设备，包括用于混合移动搜索结果的计算机程序产品。 一种方法包括接收搜索查询和多个搜索结果。 搜索结果各自满足搜索查询并具有相应的搜索结果质量得分。 搜索结果包括通用和移动搜索结果。 通用和移动搜索结果各自分别标识通用和移动资源。 搜索结果质量得分分别包括移动和通用搜索结果的移动和一般搜索结果质量得分。 根据不同的评分公式生成移动搜索结果质量得分和通用搜索结果质量得分。 基于搜索查询中的一个或多个术语，搜索查询被分类为移动查询。 因此，修改一个或多个搜索结果质量得分以改进包括移动和一般搜索结果的搜索结果的排序。