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公开(公告)号：US11921115B2
公开(公告)日：2024-03-05
申请号：US15081331
申请日：2016-03-25
IPC分类号： G01N33/574 , C12N9/64
CPC分类号： G01N33/57434 , C12N9/6445 , G01N2333/96455 , G01N2496/00
摘要： Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.
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公开(公告)号：US11761962B2
公开(公告)日：2023-09-19
申请号：US14671355
申请日：2015-03-27
发明人： Vincent Linder , David Steinmiller , Kim Pettersson , Timo Lovgren , Hans Lilja , Andrew J. Vickers , Peter T. Scardino
IPC分类号： G01N33/53 , G01N33/574 , G16B40/00 , G16H50/20 , G16B20/00
CPC分类号： G01N33/57434 , G16B20/00 , G16B40/00 , G16H50/20 , G01N2333/96455 , Y02A90/10
摘要： Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer.
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公开(公告)号：US11013576B2
公开(公告)日：2021-05-25
申请号：US15535665
申请日：2016-10-13
发明人： Jason Taylor , David Steinmiller , Hardeep Singh , Rebecca Wagner , Gary J. Fagan , Vincent Linder
摘要： Articles and methods for preparing a surface for obtaining a patient sample, such as blood, are generally provided. In some embodiments, the methods involve wiping a surface of skin of a patient in preparation for obtaining a sample (e.g., a blood sample) from the patient. In some embodiments, the methods involve wiping the surface of the skin with two or more wipes. For instance, the surface of the skin may be wiped with a first wipe comprising a surfactant and a second wipe comprising an antiseptic solution. Advantageously, the use of a first wipe including a surfactant followed by a second wipe may remove a higher amount of certain contaminants (e.g., proteins, bacteria, viruses) from the surface of the skin as compared to the use of a single wipe or by hand-washing alone.
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公开(公告)号：US10953398B2
公开(公告)日：2021-03-23
申请号：US15828999
申请日：2017-12-01
发明人： Enqing Tan , Vincent Linder , Jason Taylor , David Steinmiller
IPC分类号： F16K11/20 , B01L3/00 , G01N33/543
摘要： The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.
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公开(公告)号：US10775369B2
公开(公告)日：2020-09-15
申请号：US15197107
申请日：2016-06-29
发明人： Vincent Linder , David Steinmiller , Samuel K. Sia
IPC分类号： B01L3/00 , G01N33/53 , G01N33/543 , C12Q1/6834 , G01N21/64 , G01N33/545 , C12Q1/68 , G01F22/00
摘要： Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
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公开(公告)号：US10408824B2
公开(公告)日：2019-09-10
申请号：US14951095
申请日：2015-11-24
发明人： Vincent Linder , David Steinmiller , Samuel K. Sia
IPC分类号： B01L3/00 , G01N35/00 , G01N33/48 , G01N1/00 , G01N1/10 , G01N33/543 , G01N33/53 , C12Q1/6834 , G01N21/64 , G01N33/545 , G01F22/00
摘要： Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
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公开(公告)号：US10159978B2
公开(公告)日：2018-12-25
申请号：US15816173
申请日：2017-11-17
发明人： Vincent Linder , David Steinmiller
IPC分类号： B01L3/00
摘要： Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.
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公开(公告)号：US20180085753A1
公开(公告)日：2018-03-29
申请号：US15787078
申请日：2017-10-18
发明人： David Steinmiller , Vincent Linder
IPC分类号： B01L3/00 , G01N33/543 , G01N33/545 , G01N33/574 , G01N33/53 , G01N21/59 , G01N21/03
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/502715 , B01L2200/12 , B01L2300/04 , B01L2300/0627 , B01L2300/0654 , B01L2300/0861 , B01L2300/12 , C12Y304/21077 , G01N21/0303 , G01N21/59 , G01N33/53 , G01N33/54366 , G01N33/54373 , G01N33/545 , G01N33/57488 , G01N2333/96455 , Y10T436/11
摘要： Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.
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公开(公告)号：US09861980B2
公开(公告)日：2018-01-09
申请号：US15385117
申请日：2016-12-20
发明人： Enqing Tan , Vincent Linder , Jason Taylor , David Steinmiller
CPC分类号： B01L3/502723 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2200/0673 , B01L2200/0684 , B01L2300/0867 , B01L2300/0877 , B01L2400/0487 , B01L2400/0694 , G01N33/54366 , Y10T137/0318 , Y10T137/0329 , Y10T137/86292 , Y10T137/87652
摘要： The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.
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公开(公告)号：US20170370938A9
公开(公告)日：2017-12-28
申请号：US15081331
申请日：2016-03-25
发明人： Vincent Linder , Christina Higgins
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , C12N9/6445 , G01N2333/96455 , G01N2496/00
摘要： Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.
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