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公开(公告)号：US20250032782A1
公开(公告)日：2025-01-30
申请号：US18427620
申请日：2024-01-30
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin
IPC: A61N1/05 , A61F7/12 , A61H1/00 , A61H9/00 , A61H21/00 , A61H23/02 , A61M31/00 , A61N1/04 , A61N1/36 , A61N1/378 , A61N7/00 , H02J7/00
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20240252814A1
公开(公告)日：2024-08-01
申请号：US18463085
申请日：2023-09-07
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Daniel N. Hamilton , Manfred Franke , Douglas Michael Ackermann
CPC classification number: A61N1/0546 , A61N1/36014 , A61N1/0456 , A61N1/36034
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US20210069496A1
公开(公告)日：2021-03-11
申请号：US17018888
申请日：2020-09-11
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Amitava Gupta , John L. Wardle , Christopher William Stivers , Anand Doraiswamy , Marie Dvorak Christ , F. Richard Christ
IPC: A61N1/05 , H01B1/12 , A61N1/04 , C08F220/54 , C08F230/08 , C08F220/20
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US10940310B2
公开(公告)日：2021-03-09
申请号：US16357033
申请日：2019-03-18
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Daniel N. Hamilton , Manfred Franke , Douglas Michael Ackermann
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US10207108B2
公开(公告)日：2019-02-19
申请号：US14920852
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , Janusz Kuzma , Paul Taehyun Yun , Douglas Michael Ackermann
Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
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Patent Agency Ranking
公开(公告)号：US20180064942A1
公开(公告)日：2018-03-08
申请号：US15811369
申请日：2017-11-13
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN
IPC: A61N1/36
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/3756
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
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公开(公告)号：US20160367795A1
公开(公告)日：2016-12-22
申请号：US15256392
申请日：2016-09-02
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Jarren Armond BALDWIN , Daniel N. HAMILTON , Janusz KUZMA , Christopher William STIVERS , Manfred FRANKE
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
Abstract translation: 这里描述了通过向鼻腔或鼻窦组织提供刺激来治疗一种或多种病症（如干眼症）或改善眼部健康的装置，系统和方法。 通常，设备可以是手持式的或可植入的。 在一些变型中，手持装置可以具有刺激器主体和具有一个或多个鼻插入尖端的刺激器探针。 当装置和系统用于治疗干眼症时，可以刺激鼻或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼部表面的健康。
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公开(公告)号：US20160158548A1
公开(公告)日：2016-06-09
申请号：US15041916
申请日：2016-02-11
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20140316310A1
公开(公告)日：2014-10-23
申请号：US14256916
申请日：2014-04-18
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US10426958B2
公开(公告)日：2019-10-01
申请号：US15367030
申请日：2016-12-01
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Manfred Franke , Douglas Michael Ackermann
IPC: A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0488 , A61B5/053
Abstract: Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal.
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