-
1.发明申请Swine Population Having Low Levels of Porcine Endogenous Retrovirus and Uses Thereof 有权猪内源性逆转录病毒水平低的猪群及其用途公开(公告)号：US20080152625A1
公开(公告)日：2008-06-26
申请号：US11911653
申请日：2006-04-13
CPC分类号： A61L27/3604 , A01K67/02 , A01K2227/108 , A01K2267/02 , A61L27/3804 , C12N2740/10011
摘要： The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
摘要翻译： 本发明涉及选择和维持具有低拷贝数的猪内源性逆转录病毒的猪群的方法，以及使用这样的猪作为适于异种移植的细胞源，组织和/或器官的来源。 本发明还涉及用于从这样的猪中选择适用于异种移植的细胞，组织和/或器官的方法。
-
公开(公告)号：US08580248B2
公开(公告)日：2013-11-12
申请号：US10599518
申请日：2005-03-30
申请人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
发明人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
CPC分类号： C12N5/067 , A61K2035/126 , C12N2501/33 , C12N2501/335 , C12N2501/39 , C12N2502/1323 , C12N2533/74
摘要： The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
摘要翻译： 本发明涉及一种能够分泌肝脏分泌因子的肝细胞和非肝细胞培养物的改进方法及其在可植入组合物中用于治疗有需要的患者的肝病和疾病的用途。
-
3.发明授权Swine population having low levels of porcine endogenous retrovirus and uses thereof 有权猪内源性逆转录病毒水平低的猪群及其用途公开(公告)号：US08088969B2
公开(公告)日：2012-01-03
申请号：US11911653
申请日：2006-04-13
IPC分类号： C12N5/00
CPC分类号： A61L27/3604 , A01K67/02 , A01K2227/108 , A01K2267/02 , A61L27/3804 , C12N2740/10011
摘要： The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
摘要翻译： 本发明涉及选择和维持具有低拷贝数的猪内源性逆转录病毒的猪群的方法，以及使用这样的猪作为适于异种移植的细胞源，组织和/或器官的来源。 本发明还涉及用于从这样的猪中选择适用于异种移植的细胞，组织和/或器官的方法。
-
公开(公告)号：US20080181924A1
公开(公告)日：2008-07-31
申请号：US10599518
申请日：2005-03-30
申请人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
发明人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
CPC分类号： C12N5/067 , A61K2035/126 , C12N2501/33 , C12N2501/335 , C12N2501/39 , C12N2502/1323 , C12N2533/74
摘要： The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
摘要翻译： 本发明涉及一种能够分泌肝脏分泌因子的肝细胞和非肝细胞培养物的改进方法及其在可植入组合物中的用途，用于治疗有需要的患者的肝病和疾病。
-
公开(公告)号：US20050042746A1
公开(公告)日：2005-02-24
申请号：US10490717
申请日：2002-09-27
申请人： Olga Garkavenko
发明人： Olga Garkavenko
CPC分类号： C12N5/0697 , A61K35/12 , C12N5/0677 , C12N5/0683 , C12N2500/34 , C12N2500/38 , C12N2502/1323 , C12N2502/22 , C12N2502/246
摘要： Over time, cultured mammalian cells aggregate into an artificial tissue with 10% homologous serum and nicotinamide. Neonatal porcine islets alone have a SGS index of 4.6. Co-culture with neonatal porcine Sertoli cells formed free-floating islet-like structures, 300-600 microns in diameter (SGS index 21). Basal secretion of insulin remains high for islets in a heavily confluent mixed cell culture. Re-seeded cultures were very responsive to glucose (SGS index 21.8). Co-culture with fibroblasts also provides a high SGS index, permitting use of the recipient's fibroblast line as support/trophic cells for an xenotransplantable graft, as for treatment of diabetes.
摘要翻译： 随着时间的推移，培养的哺乳动物细胞聚集成具有10％同源血清和烟酰胺的人造组织。 新生儿猪胰岛的SGS指数为4.6。 与新生猪共同培养，Sertoli细胞形成自由浮动的胰岛样结构，直径为300-600微米（SGS指数21）。 在大量汇合的混合细胞培养物中胰岛的基础分泌胰岛素仍然很高。 再种子培养物对葡萄糖（SGS指数21.8）非常敏感。 与成纤维细胞的共培养物也提供高SGS指数，允许使用接受者的成纤维细胞系作为异种移植移植物的支持/营养细胞，用于治疗糖尿病。
-
-
-
-
搜索结果
5 条记录 (耗时 0.014 秒)
