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1.发明申请Swine Population Having Low Levels of Porcine Endogenous Retrovirus and Uses Thereof 有权猪内源性逆转录病毒水平低的猪群及其用途公开(公告)号：US20080152625A1
公开(公告)日：2008-06-26
申请号：US11911653
申请日：2006-04-13
CPC分类号： A61L27/3604 , A01K67/02 , A01K2227/108 , A01K2267/02 , A61L27/3804 , C12N2740/10011
摘要： The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
摘要翻译： 本发明涉及选择和维持具有低拷贝数的猪内源性逆转录病毒的猪群的方法，以及使用这样的猪作为适于异种移植的细胞源，组织和/或器官的来源。 本发明还涉及用于从这样的猪中选择适用于异种移植的细胞，组织和/或器官的方法。
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2.发明授权Swine population having low levels of porcine endogenous retrovirus and uses thereof 有权猪内源性逆转录病毒水平低的猪群及其用途公开(公告)号：US08088969B2
公开(公告)日：2012-01-03
申请号：US11911653
申请日：2006-04-13
IPC分类号： C12N5/00
CPC分类号： A61L27/3604 , A01K67/02 , A01K2227/108 , A01K2267/02 , A61L27/3804 , C12N2740/10011
摘要： The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
摘要翻译： 本发明涉及选择和维持具有低拷贝数的猪内源性逆转录病毒的猪群的方法，以及使用这样的猪作为适于异种移植的细胞源，组织和/或器官的来源。 本发明还涉及用于从这样的猪中选择适用于异种移植的细胞，组织和/或器官的方法。
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公开(公告)号：US20080181924A1
公开(公告)日：2008-07-31
申请号：US10599518
申请日：2005-03-30
申请人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
发明人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
CPC分类号： C12N5/067 , A61K2035/126 , C12N2501/33 , C12N2501/335 , C12N2501/39 , C12N2502/1323 , C12N2533/74
摘要： The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
摘要翻译： 本发明涉及一种能够分泌肝脏分泌因子的肝细胞和非肝细胞培养物的改进方法及其在可植入组合物中的用途，用于治疗有需要的患者的肝病和疾病。
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公开(公告)号：US08580248B2
公开(公告)日：2013-11-12
申请号：US10599518
申请日：2005-03-30
申请人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
发明人： Robert Bartlett Elliott , Olga Garkavenko , Alfred Vasconcellos , Dwaine Emerich , Chris Thanos
CPC分类号： C12N5/067 , A61K2035/126 , C12N2501/33 , C12N2501/335 , C12N2501/39 , C12N2502/1323 , C12N2533/74
摘要： The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
摘要翻译： 本发明涉及一种能够分泌肝脏分泌因子的肝细胞和非肝细胞培养物的改进方法及其在可植入组合物中用于治疗有需要的患者的肝病和疾病的用途。
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公开(公告)号：US08129186B2
公开(公告)日：2012-03-06
申请号：US11911961
申请日：2006-04-18
申请人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
发明人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
IPC分类号： C12N5/02
CPC分类号： C12N5/0018 , C12N2502/08
摘要： The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.
摘要翻译： 本发明涉及脉络丛神经细胞和/或脉络丛条件培养基用于增强长期或短期培养中生长的非脉络丛神经细胞的生长，存活和/或维持功能的用途。
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公开(公告)号：US20090162325A1
公开(公告)日：2009-06-25
申请号：US11916963
申请日：2006-06-07
CPC分类号： A61K35/30 , A61K38/28 , A61K2300/00
摘要： The present invention is directed to the prevention or treatment of autoimmune diseases, and in particular, of type I diabetes, by administering a therapeutically effective amount of an implantable composition comprising living choroid plexus cells.
摘要翻译： 本发明涉及通过施用治疗有效量的包含活动性脉络丛细胞的可植入组合物来预防或治疗自身免疫疾病，特别是I型糖尿病。
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公开(公告)号：US20080279827A1
公开(公告)日：2008-11-13
申请号：US11932538
申请日：2007-10-31
CPC分类号： C12N5/0677 , A61K35/12 , A61K2035/128 , C12N2500/38 , C12N2501/998 , C12N2501/999 , C12N2509/00
摘要： The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of: (I) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide. Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.
摘要翻译： 本发明涉及哺乳动物糖尿病治疗的发展。 特别地涉及一种制备能够在合适的受体哺乳动物中异种移植产生猪胰岛素的异种移植的猪胰岛制剂的方法，所述方法包括或包括以下步骤：（I）在全期妊娠或接近全期妊娠收获仔猪的胰腺， 和（ii）从收获的胰腺中提取胰岛β岛细胞，其中胰岛（至少在该方法的某一阶段）暴露于烟酰胺。 此外，本发明涉及一种非异种移植的猪胰岛制剂的包封方法，以及将这种制剂或含有这种制剂的胶囊移植到合适的受体哺乳动物中。
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公开(公告)号：US07122177B2
公开(公告)日：2006-10-17
申请号：US09857325
申请日：2001-01-19
CPC分类号： C12N5/0677 , A61K35/12 , A61K2035/128 , C12N2500/38 , C12N2501/998 , C12N2501/999 , C12N2509/00
摘要： The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of: (I) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide. Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.
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公开(公告)号：US08142769B2
公开(公告)日：2012-03-27
申请号：US11932538
申请日：2007-10-31
CPC分类号： C12N5/0677 , A61K35/12 , A61K2035/128 , C12N2500/38 , C12N2501/998 , C12N2501/999 , C12N2509/00
摘要： The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of: (I) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide. Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.
摘要翻译： 本发明涉及哺乳动物糖尿病治疗的发展。 特别地涉及一种制备能够在合适的受体哺乳动物中异种移植产生猪胰岛素的异种移植的猪胰岛制剂的方法，所述方法包括或包括以下步骤：（I）在全期妊娠或接近全期妊娠收获仔猪的胰腺， 和（ii）提取胰腺; 其中胰岛（至少在该方法的某一阶段）暴露于烟酰胺的胰腺细胞。 此外，本发明涉及一种非异种移植的猪胰岛制剂的包封方法，以及将这种制剂或含有这种制剂的胶囊移植到合适的受体哺乳动物中。
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公开(公告)号：US20100310627A1
公开(公告)日：2010-12-09
申请号：US12858180
申请日：2010-08-17
申请人： Robert Bartlett Elliott , Stephen John Martin Skinner , Alfred Vasconcellos , Dwaine Emerich , Cesar Venturina Borlongan , Christopher Edward Williams
发明人： Robert Bartlett Elliott , Stephen John Martin Skinner , Alfred Vasconcellos , Dwaine Emerich , Cesar Venturina Borlongan , Christopher Edward Williams
CPC分类号： A61K35/30 , A61K9/0085 , A61K9/4816 , A61K35/12 , A61K2035/128 , A61L27/3813 , A61L27/383 , A61L27/3878 , C12N5/0618 , C12N5/069
摘要： Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal.
摘要翻译： 公开了用于治疗哺乳动物中枢神经系统的神经疾病的植入物组合物和方法。
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