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    Devices, systems and methods for therapeutic muscle stimulation
    1.
    发明授权
    Devices, systems and methods for therapeutic muscle stimulation 有权

    公开(公告)号：US11478630B2

    公开(公告)日：2022-10-25

    申请号：US16954999

    申请日：2018-12-17

    申请人： Dan Sachs ,  Orhan Soykan

    发明人： Dan Sachs ,  Orhan Soykan

    IPC分类号： A61N1/04 ,  A61N1/36

    摘要： Devices, systems and methods are described for providing muscle contraction stimulation therapy to treat myriad diseases, including heart failure, Type 2 diabetes, and peripheral vascular disease using a skin patch or implantable stimulator that includes a multiplicity of electrodes, a processor, a stimulation circuit, one or more sensors and programming for a patient interface unit, wherein the processor is programmed to control selection of a subset of the multiplicity of electrodes and of operation of the stimulation circuit responsive to an indication of an adverse physiologic response. The indication of patient discomfort may be determined by monitoring a physiologic parameter of the subject using the one or more sensors, by direct input from the subject via the patient interface unit programming, or a combination thereof.

    Self-improving identification method
    3.
    发明授权
    Self-improving identification method 有权
    自我改进识别方法

    公开(公告)号：US08335652B2

    公开(公告)日：2012-12-18

    申请号：US11157568

    申请日：2005-06-21

    申请人： Orhan Soykan ,  Daisy Phan Cross

    发明人： Orhan Soykan ,  Daisy Phan Cross

    IPC分类号： G01N33/00

    CPC分类号： G06F19/24 ,  G06F19/18 ,  G06F19/28

    摘要： A self-improving identification method classifies specimens based on class identifiers. The system stores specimen profiles in a database that is updated with additional specimen profiles and with follow-up data that corrects classification of specimens that were initially incorrectly classified. Algorithms use the updated database to discover new class identifiers, modify thresholds of known class identifiers, and drop unnecessary class identifiers to improve classification of specimens.

    摘要翻译： 自我改进识别方法根据类标识符对标本进行分类。 系统将样本轮廓存储在使用附加样本轮廓更新的数据库中，并具有校正最初错误分类的样本分类的后续数据。 算法使用更新的数据库来发现新的类标识符，修改已知类标识符的阈值，并删除不必要的类标识符以改进样本分类。

    Optical detector for enzyme activation
    4.
    发明授权
    Optical detector for enzyme activation 有权
    用于酶活化的光学检测器

    公开(公告)号：US08003373B2

    公开(公告)日：2011-08-23

    申请号：US12127908

    申请日：2008-05-28

    申请人： Orhan Soykan ,  Maura G. Donovan

    发明人： Orhan Soykan ,  Maura G. Donovan

    IPC分类号： C12M1/34

    CPC分类号： A61B5/14546 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4839 ,  A61B5/7203 ,  C12Q1/37 ,  C12Q1/56 ,  G01N21/6428 ,  G01N21/8507 ,  G01N33/86 ,  G01N2021/6415 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/8528

    摘要： Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy, at the second and third wavelengths.

    摘要翻译： 基于酶的底物的切割量检测体液中酶的活化。 用两种荧光染料 - 供体和受体标记底物。 标记的基质被呈现给体液。 器件将第一波长的能量发射到体液中，并响应于第一波长的能量，检测由染料发射的第二和第三波长处的能量。 在衬底的酶切割之前，受体以响应于通过来自供体的荧光共振能量转移（FRET）接收的第二波长的能量而在第三波长处发射能量。 在酶切割底物之后，供体在第二波长处发射能量。 该装置可以基于在第二和第三波长处的能量的相对强度来确定体液中活化酶的浓度。

    Optical detector for enzyme activation
    5.
    发明授权
    Optical detector for enzyme activation 有权
    用于酶活化的光学检测器

    公开(公告)号：US07473548B2

    公开(公告)日：2009-01-06

    申请号：US10423112

    申请日：2003-04-25

    申请人： Orhan Soykan ,  Maura G. Donovan ,  Amy E. Thompson

    发明人： Orhan Soykan ,  Maura G. Donovan ,  Amy E. Thompson

    IPC分类号： C12M1/34

    CPC分类号： A61B5/14546 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4839 ,  A61B5/7203 ,  C12Q1/37 ,  C12Q1/56 ,  G01N21/6428 ,  G01N21/8507 ,  G01N33/86 ,  G01N2021/6415 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/8528

    摘要： Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy at the second and third wavelengths.

    摘要翻译： 基于酶的底物的切割量检测体液中酶的活化。 用两种荧光染料 - 供体和受体标记底物。 标记的基质被呈现给体液。 器件将第一波长的能量发射到体液中，并响应于第一波长的能量，检测由染料发射的第二和第三波长处的能量。 在衬底的酶切割之前，受体以响应于通过来自供体的荧光共振能量转移（FRET）接收的第二波长的能量而在第三波长处发射能量。 在酶切割底物之后，供体在第二波长处发射能量。 该装置可以基于在第二和第三波长处的能量的相对强度来确定体液内活化酶的浓度。

    Method and device to form a sensor using isolated cardiomyocytes
    6.
    发明授权
    Method and device to form a sensor using isolated cardiomyocytes 有权
    使用隔离心肌细胞形成传感器的方法和装置

    公开(公告)号：US07310545B1

    公开(公告)日：2007-12-18

    申请号：US10409537

    申请日：2003-04-08

    申请人： Orhan Soykan

    发明人： Orhan Soykan

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0488 ,  A61B18/1492 ,  A61B2018/00351 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00839

    摘要： A method and device are described to form a sensor using a cardiomyocyte by advancing a catheter into the tissue of interest, cardiac in the preferred embodiment, and using the catheter to ablate a cone- or a dome-shaped region to form an electrically isolated section of tissue. An electrode is later fixed to the region encompassed by the dome-shaped area of tissue and used to detect the electrophysiological activity of this electrically independent cluster of cells. These cells combined with the electrode and a detection circuitry will form a cell-based sensor to monitor the effects of the anti-arrhythmic drugs in the circulation. The inventive device includes an ablation catheter and a sensing lead. Catheter is a hollow conductor which used to carry RF power from the external generator to the myocardium and to form a cone-shaped ablation zone to electrically isolate a part of myocardium from the rest. Sensing lead is a conductor that carries electrical signals from the isolated myocardium back to the implanted monitoring device. Implantable device is the main unit for processing the signals coming back from the sensing lead.

    摘要翻译： 描述了一种方法和装置，以在优选实施例中通过将导管推进到感兴趣的组织，心脏中并使用导管来消融锥形​​或圆顶形区域以形成电隔离部分来形成使用心肌细胞的传感器 的组织。 电极稍后固定在组织圆顶形区域所包围的区域，用于检测电独立的细胞簇的电生理活性。 这些细胞与电极和检测电路结合将形成基于细胞的传感器，以监测抗心律失常药物在循环中的作用。 本发明的装置包括消融导管和感测引线。 导管是用于将外部发生器的RF功率携带到心肌并形成锥形消融区以将一部分心肌与其余部分电隔离的中空导体。 感应引线是将隔离心肌的电信号传回植入的监测装置的导体。 可植入设备是用于处理从感测引线返回的信号的主要单元。

    Method and device to treat kidney disease
    9.
    发明授权
    Method and device to treat kidney disease 有权
    治疗肾脏疾病的方法和装置

    公开(公告)号：US08641659B2

    公开(公告)日：2014-02-04

    申请号：US13399910

    申请日：2012-02-17

    申请人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    发明人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    IPC分类号： A61M1/00

    CPC分类号： A61M1/28 ,  A61M1/1678 ,  A61M1/1696 ,  A61M1/284 ,  A61M2205/04

    摘要： The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

    摘要翻译： 本发明涉及一种通过在体腔内产生纤维化腔并进行透析或大量流体去除来透析和/或大量流体去除的方法和装置。 描述了具有纤维化室和泵的可植入医疗装置。 可以进一步提供透析室和可选的电渗析装置。 附加的控制器使用感官反馈来通过改变纤维化腔内的细胞外液体保留来调节流体水平。 该装置可用于治疗也可能患有心脏肾综合征和高血压的慢性肾脏疾病患者。