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17 条记录 (耗时 0.016 秒)

    Method for coating medical devices
    2.
    发明授权
    Method for coating medical devices 有权
    医疗器械涂层方法

    公开(公告)号：US06919100B2

    公开(公告)日：2005-07-19

    申请号：US10349457

    申请日：2003-01-22

    申请人： Pallassana V. Narayanan

    发明人： Pallassana V. Narayanan

    IPC分类号： A61K31/436 ,  A61F2/82 ,  A61L31/12 ,  A61L31/16 ,  A61P9/08 ,  B05D1/18 ,  B05D7/00 ,  B05D7/24 ,  A61L27/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  C08L27/16 ,  C08L27/20

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置或治疗特定病症的反应。 使用浸涂工艺来最小化浪费。 通过允许连续浸渍和干燥循环，使用水性胶乳聚合物乳液将任何医疗装置涂覆至所需厚度。 此外，水性胶乳聚合物乳液与基于有机溶剂的聚合物相关的桥接现象几乎不起作用。

    Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents
    5.
    发明授权
    Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents 失效
    具有固定的抗血栓形成剂的射频等离子体处理的聚合物表面

    公开(公告)号：US5591140A

    公开(公告)日：1997-01-07

    申请号：US417799

    申请日：1995-04-06

    申请人： Pallassana V. Narayanan ,  Kimberly D. Stanley

    发明人： Pallassana V. Narayanan ,  Kimberly D. Stanley

    IPC分类号： A61L33/00 ,  B29C59/14 ,  A61M25/00

    CPC分类号： B29C59/142 ,  A61L33/0029 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S530/816

    摘要： Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood during implantation or medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the polymeric substrate which had been subjected to radiofrequency plasma treatment with a water vapor medium.

    摘要翻译： 提供具有增强的生物相容性的医疗装置或医疗装置的部件的聚合物表面。 聚合物表面在植入或医疗过程中呈现与体液例如血液的抗血栓形成，纤维蛋白溶解或血栓溶解界面。 生物相容性增强剂通过间隔分子固定到聚合物基质上，间隔分子与已经用水蒸气介质进行射频等离子体处理的聚合物基质共价结合。

    Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
    6.
    发明授权
    Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents 失效
    使用射频等离子体沉积和生物活性剂的化学附着处理金属表面

    公开(公告)号：US5336518A

    公开(公告)日：1994-08-09

    申请号：US989105

    申请日：1992-12-11

    申请人： Pallassana V. Narayanan ,  Stephen M. Rowland ,  Kimberly D. Stanley

    发明人： Pallassana V. Narayanan ,  Stephen M. Rowland ,  Kimberly D. Stanley

    IPC分类号： A61L33/00 ,  A61F2/00 ,  A61M23/00

    CPC分类号： A61L33/0041 ,  A61L33/0029 ,  A61L33/0094 ,  Y10S530/815 ,  Y10S530/816 ,  Y10S623/921

    摘要： A treatment for metallic surfaces and devices having metallic surfaces is described. A film of heptafluorobutylmethacrylate (HFBMA) is applied to a surface by radiofrequency (RF) plasma deposition and subsequently treated with a biologically active agent. A water vapor RF plasma treatment of the HFBMA coating provides reactive groups thereon which can covalently bond to the biologically active agent. Alternatively, a spacer group can be bonded to the activated HFBMA and the biologically active agent can then be bonded to the spacer group. Devices coated according to the invention possess enhanced biocompatibility and the HFBMA coatings are durable even under severe crimping and expansion conditions.

    摘要翻译： 描述了具有金属表面的金属表面和装置的处理。 通过射频（RF）等离子体沉积将七氟丁基甲基丙烯酸酯（HFBMA）的膜施加到表面，随后用生物活性剂处理。 HFBMA涂层的水蒸汽RF等离子体处理在其上提供可共价键结合到生物活性剂上的反应性基团。 或者，可以将间隔基团结合到活化的HFBMA上，然后将生物活性剂与间隔基团结合。 根据本发明涂覆的装置具有增强的生物相容性，即使在严重的卷曲和膨胀条件下，HFBMA涂层也是耐用的。

    Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like
    7.
    发明授权
    Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like 失效
    射频等离子体生物相容性处理医用管内表面等

    公开(公告)号：US5244654A

    公开(公告)日：1993-09-14

    申请号：US720410

    申请日：1991-06-25

    申请人： Pallassana V. Narayanan

    发明人： Pallassana V. Narayanan

    IPC分类号： A61K35/62 ,  A61L33/00 ,  A61L33/08 ,  A61L33/10 ,  B05D3/06 ,  B05D7/24 ,  B29C59/14 ,  C08J7/04 ,  C08J7/12

    CPC分类号： C08J7/123 ,  A61L33/0011 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/08 ,  B29C59/142 ,  C08J7/12 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S530/816

    摘要： Internal polymeric surfaces of medical devices are provided that have enhanced biocompatibility properties. The internal polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood flowing through medical device tubing during implantation for medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the internal polymeric surface which had been subjected to radiofrequency plasma treatment with a low pressure plasma medium of water vapor, oxygen or combination of water vapor and oxygen gas.

    摘要翻译： 提供具有增强的生物相容性的医疗装置的内部聚合物表面。 内部聚合物表面在用于医疗程序的植入期间呈现出抗血栓形成，纤维蛋白溶解或血栓溶解界面，其中体液例如血液通过医疗装置管道流动。 生物相容性增强剂通过间隔分子固定到聚合物基质上，该间隔分子共价结合到内部聚合物表面，该内部聚合物表面已经用低压等离子体处理的水蒸汽，氧气或水蒸气和氧气的组合等离子体处理 。

    Magnetic recording element
    8.
    发明授权
    Magnetic recording element 失效
    磁记录元件

    公开(公告)号：US4849291A

    公开(公告)日：1989-07-18

    申请号：US127812

    申请日：1987-12-02

    申请人： Paul D. Yacobucci ,  Jesse T. Gerard ,  Pallassana V. Narayanan

    发明人： Paul D. Yacobucci ,  Jesse T. Gerard ,  Pallassana V. Narayanan

    IPC分类号： G11B5/72

    CPC分类号： G11B5/722 ,  Y10S428/90

    摘要： A magnetic recording element comprises a polymeric film substrate on which is formed a thin CoNi recording layer. Over the latter is a protective layer of an acrylic copolymer of a perfluoroalkyl methanol ester of acrylic or methacrylic acid, preferably formed by plasma polymerization. The layer is tough, has a low coefficient of friction and protects the magnetic layer against corrosion.

    摘要翻译： 磁记录元件包括聚合物膜基底，在其上形成薄CoNi记录层。 后者是丙烯酸或甲基丙烯酸的全氟烷基甲醇酯的丙烯酸共聚物的保护层，优选通过等离子体聚合形成。 该层是坚韧的，具有低摩擦系数并保护磁性层免受腐蚀。

    Method for applying drug coating to a medical device in surgeon room
    9.
    发明授权
    Method for applying drug coating to a medical device in surgeon room 有权
    在外科医生室中将药物涂层施用于医疗装置的方法

    公开(公告)号：US08318235B2

    公开(公告)日：2012-11-27

    申请号：US10915980

    申请日：2004-08-11

    申请人： Harry Halleriet ,  Pallassana V. Narayanan

    发明人： Harry Halleriet ,  Pallassana V. Narayanan

    IPC分类号： B05D3/02 ,  B05D1/18 ,  A61F2/06 ,  A61M39/00 ,  A61M25/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L27/16 ,  C08L27/20

    摘要： Medical devices, and in particular implantable medical devices such as stents and stent delivery systems including catheters, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste and to customize coating thickness and drug loading directly at the clinical site just prior to therapeutic use on a patient. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles at the clinical site. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.

    摘要翻译： 可以涂覆医疗装置，特别是可植入的医疗装置，例如支架和包括导管的支架输送系统，以最小化或基本上消除生物有机体对生物体引入医疗装置或治疗特定病症的反应。 使用浸涂工艺来最大限度地减少废物，并在治疗使用之前直接在临床部位定制涂层厚度和药物负荷。 使用水性胶乳聚合物乳液通过允许在临床部位连续浸渍和干燥循环将任何医疗装置涂覆至所需厚度。 此外，水性胶乳聚合物乳液与基于有机溶剂的聚合物相关的桥接现象几乎不起作用。