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    Method for coating medical devices
    3.
    发明授权
    Method for coating medical devices 有权
    医疗器械涂层方法

    公开(公告)号：US06919100B2

    公开(公告)日：2005-07-19

    申请号：US10349457

    申请日：2003-01-22

    申请人： Pallassana V. Narayanan

    发明人： Pallassana V. Narayanan

    IPC分类号： A61K31/436 ,  A61F2/82 ,  A61L31/12 ,  A61L31/16 ,  A61P9/08 ,  B05D1/18 ,  B05D7/00 ,  B05D7/24 ,  A61L27/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  C08L27/16 ,  C08L27/20

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置或治疗特定病症的反应。 使用浸涂工艺来最小化浪费。 通过允许连续浸渍和干燥循环，使用水性胶乳聚合物乳液将任何医疗装置涂覆至所需厚度。 此外，水性胶乳聚合物乳液与基于有机溶剂的聚合物相关的桥接现象几乎不起作用。

    COATING FOR CONTROLLED RELEASE OF A THERAPEUTIC AGENT
    4.
    发明申请
    COATING FOR CONTROLLED RELEASE OF A THERAPEUTIC AGENT 审中-公开
    涂层用于治疗药物的控制释放

    公开(公告)号：US20090082855A1

    公开(公告)日：2009-03-26

    申请号：US12327357

    申请日：2008-12-03

    申请人： John Borges ,  Maritza Carballo ,  Pallassana V. Narayanan ,  William D. Shaw, JR. ,  Christopher W. Widenhouse

    发明人： John Borges ,  Maritza Carballo ,  Pallassana V. Narayanan ,  William D. Shaw, JR. ,  Christopher W. Widenhouse

    IPC分类号： A61F2/82

    CPC分类号： A61K9/0024 ,  A61K31/395 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08 ,  C08L33/10 ,  C08L27/16

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

    Catheter system having fullerenes and method
    5.
    发明授权
    Catheter system having fullerenes and method 有权
    具有富勒烯和方法的导管系统

    公开(公告)号：US06468244B1

    公开(公告)日：2002-10-22

    申请号：US09555793

    申请日：2000-01-05

    申请人： James E. Leone ,  Pallassana V. Narayanan

    发明人： James E. Leone ,  Pallassana V. Narayanan

    IPC分类号： A61M2900

    CPC分类号： A61L29/103 ,  A61B2017/22002 ,  A61B2017/22064 ,  A61B2018/2261 ,  A61M25/10 ,  A61M2025/105 ,  A61N5/0601 ,  A61N5/062 ,  B82Y30/00

    摘要： At least a portion of a catheter system (10) is provided with fullerene material (56) for performing or facilitating a medical procedure. In the case of a balloon catheter, the outer surface of the balloon may have a coating of fullerenes (64), which are preferably photosensitive or activated by light. A light source (60) can be used to illuminate or other wise activate the fullerene material. The light source (60) may be formed by one or more optical fibers extending through the shaft of the catheter, and into the balloon. Various arrangements of the catheter system are possible, whereby the light source may selectively emit light outward through the fullerene material, and associated portions of the catheter system, which may be translucent. When activated by light, the fullerene coating may preferably generate, and give off therapeutic oxygen radicals. These oxygen radicals may affect local cell function to prevent or reduce cell proliferation. This therapy may have many applications, including for example, limiting restenosis after angioplasty.

    摘要翻译： 导管系统（10）的至少一部分设置有用于执行或促进医疗程序的富勒烯材料（56）。 在气囊导管的情况下，球囊的外表面可以具有富勒烯（64）的涂层，其优选是光敏的或被光激活的。 光源（60）可用于照亮或以其他方式激活富勒烯材料。 光源（60）可以由延伸穿过导管的轴并且进入气囊的一个或多个光纤形成。 导管系统的各种布置是可能的，由此光源可以选择性地通过富勒烯材料向外发射光，以及可以是半透明的导管系统的相关部分。 当通过光激活时，富勒烯涂层可以优选地产生并释放治疗性氧自由基。 这些氧自由基可能会影响局部细胞功能，以预防或减少细胞增殖。 该治疗可能有许多应用，例如，限制血管成形术后的再狭窄。

    Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents
    6.
    发明授权
    Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents 失效
    具有固定的抗血栓形成剂的射频等离子体处理的聚合物表面

    公开(公告)号：US5409696A

    公开(公告)日：1995-04-25

    申请号：US156384

    申请日：1993-11-22

    申请人： Pallassana V. Narayanan ,  Kimberly D. Stanley

    发明人： Pallassana V. Narayanan ,  Kimberly D. Stanley

    IPC分类号： A61L33/00 ,  B29C59/14 ,  A61K31/725 ,  A61K35/62 ,  A61L29/00

    CPC分类号： B29C59/142 ,  A61L33/0029 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S530/816

    摘要： Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood during implant ation or medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the polymeric substrate which had been subjected to radiofrequency plasma treatment with a water vapor medium.

    摘要翻译： 提供具有增强的生物相容性的医疗装置或医疗装置的部件的聚合物表面。 聚合物表面在植入物或医疗过程中呈现与体液例如血液的抗血栓形成，纤维蛋白溶解或血栓溶解界面。 生物相容性增强剂通过间隔分子固定到聚合物基质上，间隔分子与已经用水蒸气介质进行射频等离子体处理的聚合物基质共价结合。

    Method for applying drug coating to a medical device in surgeon room
    7.
    发明授权
    Method for applying drug coating to a medical device in surgeon room 有权
    在外科医生室中将药物涂层施用于医疗装置的方法

    公开(公告)号：US08318235B2

    公开(公告)日：2012-11-27

    申请号：US10915980

    申请日：2004-08-11

    申请人： Harry Halleriet ,  Pallassana V. Narayanan

    发明人： Harry Halleriet ,  Pallassana V. Narayanan

    IPC分类号： B05D3/02 ,  B05D1/18 ,  A61F2/06 ,  A61M39/00 ,  A61M25/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L27/16 ,  C08L27/20

    摘要： Medical devices, and in particular implantable medical devices such as stents and stent delivery systems including catheters, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste and to customize coating thickness and drug loading directly at the clinical site just prior to therapeutic use on a patient. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles at the clinical site. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.

    摘要翻译： 可以涂覆医疗装置，特别是可植入的医疗装置，例如支架和包括导管的支架输送系统，以最小化或基本上消除生物有机体对生物体引入医疗装置或治疗特定病症的反应。 使用浸涂工艺来最大限度地减少废物，并在治疗使用之前直接在临床部位定制涂层厚度和药物负荷。 使用水性胶乳聚合物乳液通过允许在临床部位连续浸渍和干燥循环将任何医疗装置涂覆至所需厚度。 此外，水性胶乳聚合物乳液与基于有机溶剂的聚合物相关的桥接现象几乎不起作用。

    Method for targeting in vivo nitric oxide release
    9.
    发明授权
    Method for targeting in vivo nitric oxide release 失效
    靶向体内一氧化氮释放的方法

    公开(公告)号：US06171232B2

    公开(公告)日：2001-01-09

    申请号：US08882880

    申请日：1997-06-26

    申请人： George Papandreou ,  Pallassana V. Narayanan

    发明人： George Papandreou ,  Pallassana V. Narayanan

    IPC分类号： A61F204

    CPC分类号： A61L33/027 ,  A61L33/0076 ,  A61L33/0088 ,  Y10S623/901

    摘要： The preparation and use of medical devices are described. A thiol group agent is loaded onto a medical device such as a stent or a catheter. Preferably, the loading is accomplished onto a polymeric surface that had been activated by water vapor RF plasma treatment. The thiol group agent is structured to exhibit sulfhydryl groups. These sulfhydryl groups are available for interaction with NO carriers such as nitrovasodilators. This interaction can take place in situ at an in vivo location within a vascular system, for example, in which event the sulfhydryl groups would be delivered by the medical device while the NO carrier will be delivered by suitable pharmaceutical administration means. Alternatively, the NO carrier can be loaded onto the treated medical device surface at a suitable time prior to insertion of the medical device into the body, such as immediately before the initiation of a medical procedure such as stent delivery and implantation.

    摘要翻译： 描述了医疗器械的制备和使用。 将硫醇基剂加载到诸如支架或导管的医疗装置上。 优选地，将负载完成到通过水蒸汽RF等离子体处理而被激活的聚合物表面上。 硫醇基试剂的结构是显示巯基。 这些巯基可用于与NO载体例如硝基血管扩张剂相互作用。 这种相互作用可以在血管系统内的体内位置原位发生，例如，在这种情况下，巯基将被医疗装置输送，而NO载体将被合适的药物施用装置递送。 或者，可以在将医疗装置插入体内的适当时间（例如在开始诸如支架输送和植入之类的医疗程序之前）将NO载体加载到经处理的医疗装置表面上。

    Radiofrequency plasma biocompatibility treatment of inside surfaces
    10.
    发明授权
    Radiofrequency plasma biocompatibility treatment of inside surfaces 失效
    内表面射频血浆生物相容性治疗

    公开(公告)号：US5486357A

    公开(公告)日：1996-01-23

    申请号：US143994

    申请日：1993-10-27

    申请人： Pallassana V. Narayanan

    发明人： Pallassana V. Narayanan

    IPC分类号： A61K35/62 ,  A61L33/00 ,  A61L33/08 ,  B29C59/14 ,  C08J7/12 ,  A61K31/725 ,  A61L29/00 ,  B05D3/06

    CPC分类号： C08J7/123 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/08 ,  B29C59/142 ,  C08J7/12 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S530/816

    摘要： Internal polymeric surfaces of medical devices are provided that have enhanced biocompatibility properties. The internal polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood flowing through medical device tubing during implantation for medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the internal polymeric surface which had been subjected to radiofrequency plasma treatment with a low pressure plasma medium of water vapor, oxygen or combination of water vapor and oxygen gas.

    摘要翻译： 提供具有增强的生物相容性的医疗装置的内部聚合物表面。 内部聚合物表面在用于医疗程序的植入期间呈现出抗血栓形成，纤维蛋白溶解或血栓溶解界面，其中体液例如血液通过医疗装置管道流动。 生物相容性增强剂通过间隔分子固定到聚合物基质上，该间隔分子共价结合到内部聚合物表面，该内部聚合物表面已经用低压等离子体处理的水蒸汽，氧气或水蒸气和氧气的组合等离子体处理 。