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46 条记录 (耗时 0.053 秒)

    Pyrroloquinoline quinone drugs for treatement of cardiac injury and methods of use thereof
    5.
    发明申请
    Pyrroloquinoline quinone drugs for treatement of cardiac injury and methods of use thereof 审中-公开
    用于治疗心脏损伤的吡咯喹啉醌药物及其使用方法

    公开(公告)号：US20080221145A1

    公开(公告)日：2008-09-11

    申请号：US11906769

    申请日：2007-10-02

    申请人： Paul J. Davis

    发明人： Paul J. Davis

    IPC分类号： A61K31/4745 ,  A01N1/02

    CPC分类号： A61K31/4745 ,  Y02A50/414

    摘要： The invention includes compositions comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a composition of the invention with a human patient.

    摘要翻译： 本发明包括包含基本上纯化的吡咯并喹啉醌的组合物，其可用于治疗和预防由缺氧或缺血引起的心脏损伤的方法。 本发明还包括治疗和预防心脏损伤的方法，包括将本发明的组合物与人类患者接触。

    Robust signaling tone frequency measurement
    6.
    发明授权
    Robust signaling tone frequency measurement 有权
    强大的信号音频率测量

    公开(公告)号：US06229889B1

    公开(公告)日：2001-05-08

    申请号：US09285670

    申请日：1999-04-05

    申请人： Joseph M. Cannon ,  James A. Johanson ,  Paul J. Davis

    发明人： Joseph M. Cannon ,  James A. Johanson ,  Paul J. Davis

    IPC分类号： H04M300

    CPC分类号： H04Q1/46

    摘要： Apparatus and methods for adaptively, reliably, and accurately measuring the frequency of an alerting or other signaling tone. A tone detector measures the frequency of a tone (continuous or pulsed) with a high degree of accuracy (e.g., to within 1 part in 10,000). Two lower order or smaller DFTs measure the energy level in two separate but intersecting frequency ranges. A simple ratio is determined from the relative energy measured from discrete Fourier transforms relating to each of the two separate frequency ranges, and an actual measured frequency is determined.

    摘要翻译： 用于自适应地，可靠地和准确地测量警报或其他信令音频率的装置和方法。 音调检测器以高精确度（例如，在10,000中的1分之1）内测量音调（连续或脉冲）的频率。 两个较低阶或更小的DFT在两个单独但相交的频率范围内测量能级。 从与两个分开的频率范围中的每一个相关的离散傅里叶变换测量的相对能量确定简单的比率，并且确定实际测量的频率。

    Monitoring method
    8.
    发明授权
    Monitoring method 失效
    监测方法

    公开(公告)号：US5467778A

    公开(公告)日：1995-11-21

    申请号：US109503

    申请日：1993-08-20

    申请人： Michael Catt ,  John Coley ,  Paul J. Davis

    发明人： Michael Catt ,  John Coley ,  Paul J. Davis

    IPC分类号： G01N33/493 ,  A61B10/00 ,  G01N20060101 ,  G01N33/50 ,  G01N33/52 ,  G01N33/68 ,  G01N33/74 ,  G01N33/76

    CPC分类号： G01N33/689 ,  A61B10/0012 ,  G01N33/743 ,  G01N33/76 ,  G01N2800/36

    摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles. Preferably testing for said analyte concentration during the current ovulation cycle is commenced a plurality of days (preferably at least 5) following the onset of menses but at least 2 numerical days in advance of the earliest numerical day on which actual ovulation has occurred in one or more previous ovulation cycles in the same individual subject.

    摘要翻译： 一种监测个体人类女性受试者当前排卵周期状态的方法，包括在至少部分时间内测量相对于排卵周期状态（例如尿E3G）的有意义的分析物的体液浓度 个体受试者当前排卵周期的排卵前阶段以及相对于已经适应于个体受试者的分析物浓度参考值的来自这种测试结果的指示即将排卵的分析物浓度变化的鉴定 在一个或多个以前的排卵周期中从个体人受试者获得的分析物浓度测试数据的基础。 优选地，在当前排卵周期期间对所述分析物浓度的测试在月经开始之后开始多天（优选至少5天），但是在实际排卵发生在一个或多个之前的最早数字日之前的至少2个数天 在同一个体科目中更多的排卵周期。

    Process and apparatus for carrying out specific binding assays
    9.
    发明授权
    Process and apparatus for carrying out specific binding assays 失效
    用于进行特异性结合测定的方法和装置

    公开(公告)号：US4889816A

    公开(公告)日：1989-12-26

    申请号：US56307

    申请日：1987-06-01

    申请人： Paul J. Davis ,  Philip Porter

    发明人： Paul J. Davis ,  Philip Porter

    IPC分类号： G01N33/543 ,  G01N33/577

    CPC分类号： G01N33/54393 ,  G01N33/54366 ,  G01N33/577 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81

    摘要： An immunoassay for an analyte is disclosed in which (a) sample, (b) an immobilized specific binding partner for the analyte and (c) the specific binding partner for the analyte conjugated to a detectable marker are reacted together in a single step. Competitive interference of the reagents is avoided by using reagent (c) in a slow-release form as a glaze coated on a surface in contact with the reaction liquid.

    摘要翻译： 公开了一种分析物的免疫测定法，其中（a）样品，（b）分析物的固定化特异性结合配偶体和（c）与可检测标记物缀合的分析物的特异性结合配偶体在一个步骤中一起反应。 通过使用试剂（c）以缓释形式作为涂覆在与反应液体接触的表面上的釉料来避免试剂的竞争性干扰。

    Method and compositions for the control of coccidiosis in poultry
    10.
    发明授权
    Method and compositions for the control of coccidiosis in poultry 失效
    用于控制禽类球虫病的方法和组合物

    公开(公告)号：US4863731A

    公开(公告)日：1989-09-05

    申请号：US52688

    申请日：1987-05-20

    申请人： Paul J. Davis ,  James F. Reynolds

    发明人： Paul J. Davis ,  James F. Reynolds

    IPC分类号： A23K1/00 ,  A61K35/68 ,  A61K39/012

    CPC分类号： A61K39/012 ,  A23K10/18 ,  A61K35/68

    摘要： Aqueous concentrates intended for addition to nutrient material in the manufacture of feedstuffs for poultry are provided consisting essentially of water and from about 1000 to about 1,000,000 viable sporulated oocysts of at least one species of coccidia to which poultry are susceptible and at least one edible thickening agent which facilitates the mixing of the oocysts into feedstuff without destructive frictional heat.

    摘要翻译： 提供用于在家禽饲料制造中添加营养物质的水性浓缩物基本上由水和约1000至约1,000,000种至少一种家禽易感的球虫的活孢子化卵囊和至少一种可食用增稠剂 这有助于将卵囊混合到饲料中而没有破坏性的摩擦热。