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    METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS
    1.
    发明申请
    METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS 审中-公开
    用于增强基因转移细胞的递送的方法

    公开(公告)号：US20140199279A1

    公开(公告)日：2014-07-17

    申请号：US13978338

    申请日：2011-12-27

    申请人： Julian David Down ,  Philippe Louis Leboulch

    发明人： Julian David Down ,  Philippe Louis Leboulch

    IPC分类号： C12N15/86

    CPC分类号： C12N15/86 ,  A61K35/32 ,  A61K2035/124 ,  C12N2740/16043

    摘要： The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders.

    摘要翻译： 本发明提供用于增强转导细胞向受试者的递送的新方法，其包括选择转导的细胞的两种方法和增强移植受体中的转导细胞重建的方法。 本发明还提供了可用于实施本发明方法的转移载体，包括慢病毒载体。 本发明的方法和载体可用于各种疾病和病症的基因治疗，包括但不限于血液疾病和病症。

    Player specific limited licenses
    3.
    发明授权
    Player specific limited licenses 有权

    公开(公告)号：US09715580B2

    公开(公告)日：2017-07-25

    申请号：US13009605

    申请日：2011-01-19

    申请人： Philippe Louis Yves Paquet ,  Amy Beth Kalson

    发明人： Philippe Louis Yves Paquet ,  Amy Beth Kalson

    IPC分类号： G06Q20/00 ,  G06F21/10

    CPC分类号： G06F21/10 ,  G06F2221/2109 ,  G06F2221/2137 ,  G06F2221/2141

    摘要： One embodiment of the present invention sets forth a method for providing a user access to a gaming environment without a full license. In operation, a license generator receive a request to generate a temporary license for a user not having access to the gaming environment from a primary user having a full license. The license generator then generates the temporary license based on license information associated with the full license belonging to a primary user. The user can then access the gaming environment via the temporary license, but may only be given restricted access to the gaming environment.

    Apparatus for handling geological samples
    4.
    发明授权
    Apparatus for handling geological samples 失效
    用于处理地质样品的设备

    公开(公告)号：US06425447B1

    公开(公告)日：2002-07-30

    申请号：US09596401

    申请日：2000-06-16

    申请人： Pascal Bartette ,  Philippe Louis Cravatte

    发明人： Pascal Bartette ,  Philippe Louis Cravatte

    IPC分类号： E21B4900

    CPC分类号： E21B25/06

    摘要： A method and apparatus for handling a geological sample, such as a core from a formation. The formation may be a formation of an oil and/or gas well. The apparatus includes a container for receiving the sample and is characterized in that the container comprises at least one wall with a surface which can change its configuration in response to pressure changes. The method of handling a geological sample obtained includes providing a container for receiving the sample. The container has a surface which is capable of changing its configuration in response to pressure changes. The sample is introduced into the container, and the configuration of the surface is changed to contact the sample. The container is then withdrawn from the formation.

    摘要翻译： 一种用于处理地质样品的方法和装置，例如地层的核心。 地层可以是油和/或气井的形成。 该装置包括用于接收样品的容器，其特征在于，所述容器包括至少一个具有表面的壁，所述壁可响应于压力变化而改变其构型。 处理所获得的地质样品的方法包括提供用于接收样品的容器。 容器具有能够响应于压力变化而改变其构造的表面。 将样品引入容器中，并更换表面的构型以接触样品。 然后将容器从地层中取出。

    Interrupt architecture for a non-uniform memory access (NUMA) data processing system
    6.
    发明授权
    Interrupt architecture for a non-uniform memory access (NUMA) data processing system 失效
    用于非均匀内存访问（NUMA）数据处理系统的中断架构

    公开(公告)号：US6148361A

    公开(公告)日：2000-11-14

    申请号：US213998

    申请日：1998-12-17

    申请人： Gary Dale Carpenter ,  Philippe Louis deBacker ,  Mark Edward Dean ,  David Brian Glasco ,  Ronald Lynn Rockhold

    发明人： Gary Dale Carpenter ,  Philippe Louis deBacker ,  Mark Edward Dean ,  David Brian Glasco ,  Ronald Lynn Rockhold

    IPC分类号： G06F15/173 ,  G06F9/48 ,  G06F13/24

    CPC分类号： G06F9/4812

    摘要： A non-uniform memory access (NUMA) computer system includes at least two nodes coupled by a node interconnect, where at least one of the nodes includes a processor for servicing interrupts. The nodes are partitioned into external interrupt domains so that an external interrupt is always presented to a processor within the external interrupt domain in which the interrupt occurs. Although each external interrupt domain typically includes only a single node, interrupt channeling or interrupt funneling may be implemented to route external interrupts across node boundaries for presentation to a processor. Once presented to a processor, interrupt handling software may then execute on any processor to service the external interrupt. Servicing external interrupts is expedited by reducing the size of the interrupt handler polling chain as compared to prior art methods. In addition to external interrupts, the interrupt architecture of the present invention supports inter-processor interrupts (IPIs) by which any processor may interrupt itself or one or more other processors in the NUMA computer system. IPIs are triggered by writing to memory mapped registers in global system memory, which facilitates the transmission of IPIs across node boundaries and permits multicast IPIs to be triggered simply by transmitting one write transaction to each node containing a processor to be interrupted. The interrupt hardware within each node is also distributed for scalability, with the hardware components communicating via interrupt transactions conveyed across shared communication paths.

    摘要翻译： 非均匀存储器访问（NUMA）计算机系统包括由节点互连耦合的至少两个节点，其中至少一个节点包括用于维护中断的处理器。 节点被划分为外部中断域，以便外部中断始终呈现给发生中断的外部中断域内的处理器。 虽然每个外部中断域通常仅包括一个节点，但是可以实现中断通道或中断漏斗，以跨越节点边界路由外部中断以呈现给处理器。 一旦提交给处理器，中断处理软件就可以在任何处理器上执行以服务外部中断。 与现有技术的方法相比，通过减小中断处理程序轮询链的大小来加快服务外部中断。 除了外部中断之外，本发明的中断架构还支持处理器间中断（IPI），通过该处理器中断，任何处理器可以中断自身或NUMA计算机系统中的一个或多个其他处理器。 通过写入全局系统存储器中的存储器映射寄存器来触发IPI，这有助于跨越节点边界的IPI的传输，并且允许通过向包含待中断的处理器的每个节点发送一个写入事务来简单地触发多播IPI。 每个节点中的中断硬件也被分配用于可扩展性，硬件组件通过跨共享通信路径传送的中断事务进行通信。

    Afterburner flame holder with rotationally-splitting radial arms
    7.
    发明授权
    Afterburner flame holder with rotationally-splitting radial arms 失效
    加力燃烧器具有旋转分裂的径向臂

    公开(公告)号：US6098401A

    公开(公告)日：2000-08-08

    申请号：US81281

    申请日：1998-05-20

    申请人： Philippe Louis Andre Alassoeur ,  Xavier Jean Michel Andre Guyonnet ,  Pascal Michel Daniel Le Jeune

    发明人： Philippe Louis Andre Alassoeur ,  Xavier Jean Michel Andre Guyonnet ,  Pascal Michel Daniel Le Jeune

    IPC分类号： F02K3/10 ,  F02K1/38 ,  F23R3/22

    CPC分类号： F23R3/22 ,  F02K1/386

    摘要： An afterburn device for a turbojet engine comprises a flame arrester formed by a plurality of radial arms distributed evenly around the rotational axis of the engine at the upstream end of the afterburn chamber. Each arm consists of a fixed rear part, and a front part which is separable from the rear part in a circumferential direction along a median joint plane, the front parts being carried on a ring which is rotatably mounted on the outer casing of the engine. Drive means is provided for rotating the ring between a first position for dry operation, and a second position for afterburn operation. In the first position the front and rear parts of the arms are aligned and joined to provide the arms with a streamlined, low-drag, zero angle of incidence profile suitable for dry operation. In the second position the front parts of the arms are separated circumferentially from the rear parts so as to alternate with the rear parts, the front and rear parts creating turbulence which acts to arrest the flame during afterburn operation.

    摘要翻译： 用于涡轮喷气发动机的再燃烧装置包括由在再燃烧室的上游端均匀分布在发动机的旋转轴线上的多个径向臂形成的阻火器。 每个臂由固定的后部和沿着中间接合面在圆周方向上与后部分离的前部构成，前部承载在可旋转地安装在发动机的外壳上的环上。 提供驱动装置，用于在第一位置和第二位置之间转动用于干燥操作的第一位置。 在第一位置，臂的前部和后部对准并连接，以使臂具有适合于干燥操作的流线型，低阻力，零入射角。 在第二位置，臂的前部与后部沿周向分离，以便与后部交替，前后部分产生在后燃操作期间阻止火焰的湍流。

    Flight control device for an aircraft, in particular a helicopter
    8.
    发明授权
    Flight control device for an aircraft, in particular a helicopter 失效
    飞机的飞行控制装置，特别是一架直升机

    公开(公告)号：US6059225A

    公开(公告)日：2000-05-09

    申请号：US56301

    申请日：1998-04-06

    申请人： Pierre-Albert Vidal ,  Eddy Gaston Jean Woirin ,  Jean-Maxime Massimi ,  Philippe Louis Ressent

    发明人： Pierre-Albert Vidal ,  Eddy Gaston Jean Woirin ,  Jean-Maxime Massimi ,  Philippe Louis Ressent

    IPC分类号： B64C13/50 ,  G05D1/00 ,  B64C13/16

    CPC分类号： B64C13/503 ,  G05D1/0077 ,  Y02T50/44

    摘要： A flight control device for an aircraft is provided with a control unit OP and a plurality of N instruction generating systems, each of which generates a first command instruction for the control unit OP and a least one of which performs autosurveillance and generates a corresponding surveillance signal. The flight control device is also provided with a plurality of P servocontrol systems, each of which is coupled to each of the instruction generating systems so that each of the servocontrol systems receives one of the first command instructions from each of the N instruction generating systems. Each of the servocontrol systems receives information identifying a particular position of a flight control unit, and each of the servocontrol systems communicates a second command instruction to the control unit OP based on the information.

    摘要翻译： 飞机的飞行控制装置设置有控制单元OP和多个N指令生成系统，每个指令生成系统生成用于控制单元OP的第一命令指令，并且其中至少一个执行自动监视并产生相应的监视信号 。 飞行控制装置还设置有多个P伺服控制系统，每个P伺服控制系统中的每一个耦合到每个指令生成系统，使得每个伺服控制系统从N个指令生成系统中的每一个接收第一命令指令之一。 每个伺服控制系统接收识别飞行控制单元的特定位置的信息，并且每个伺服控制系统基于该信息将第二命令指令传送到控制单元OP。

    Capillary electrophoresis method using initialized capillary and polyanion-containing buffer and chemical kit therefor
    9.
    发明授权
    Capillary electrophoresis method using initialized capillary and polyanion-containing buffer and chemical kit therefor 失效
    毛细管电泳法使用初始化毛细管和含聚阴离子的缓冲液及其化学试剂盒

    公开(公告)号：US5611903A

    公开(公告)日：1997-03-18

    申请号：US412032

    申请日：1995-03-22

    申请人： Jacques Janssens ,  Roland Chevigne ,  Philippe Louis

    发明人： Jacques Janssens ,  Roland Chevigne ,  Philippe Louis

    IPC分类号： G01N27/447 ,  G01N27/26

    CPC分类号： G01N27/44704 ,  G01N27/44747

    摘要： A capillary electrophoresis detection and/or analysis method comprising the following steps:rinsing a ready-to-use capillary with an initiator to create an initialized capillary,adding a capillary buffer into the initialized capillary,injecting a sample to be analyzed (possibly diluted with a sample diluent) into the initialized capillary,optionally, adding a cathodic buffer to the cathodic end of the capillary, andsubmitting the sample to capillary electrophoresis.In this method, the capillary and/or cathodic buffer comprise(s) a polyanion or a mixture of polyanions. The polyanion or the mixture of polyanions is included at least in the capillary or the cathodic buffer. The method can additionally comprise rinsing the capillary with NaOH after electrophoresis.The present invention also includes a capillary electrophoresis detection and/or analysis unit, including an initiator and a capillary buffer and/or a cathodic buffer. The capillary and/or the cathodic buffer contain a polyanion or a mixture of polyanions.

    摘要翻译： 一种毛细管电泳检测和/或分析方法，包括以下步骤：用引发剂漂洗即用型毛细管以产生初始化毛细管，向初始化毛细管中加入毛细管缓冲液，注射待分析样品（可能用 样品稀释剂），任选地，将阴极缓冲液加入到毛细管的阴极端，并将样品提交到毛细管电泳。 在该方法中，毛细管和/或阴极缓冲液包含多阴离子或聚阴离子的混合物。 聚阴离子或聚阴离子的混合物至少包含在毛细管或阴极缓冲液中。 该方法还可以包括在电泳后用NaOH冲洗毛细管。 本发明还包括毛细管电泳检测和/或分析单元，其包括引发剂和毛细管缓冲液和/或阴极缓冲液。 毛细管和/或阴极缓冲液含有聚阴离子或聚阴离子的混合物。