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    Single-Use Bispectral Optical Head for Videoendoscope and Associated Videoendoscope
    2.
    发明申请
    Single-Use Bispectral Optical Head for Videoendoscope and Associated Videoendoscope 审中-公开
    用于视频内窥镜和相关视频内窥镜的单次使用双谱光学头

    公开(公告)号：US20130070071A1

    公开(公告)日：2013-03-21

    申请号：US13420467

    申请日：2012-03-14

    申请人： Philippe PELTIE ,  Jérôme BOUTET ,  Philippe RIZO

    发明人： Philippe PELTIE ,  Jérôme BOUTET ,  Philippe RIZO

    IPC分类号： H04N7/18

    CPC分类号： H04N7/18 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/05 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0684 ,  G02B23/243 ,  G02B23/2469 ,  G02B23/2484 ,  G02B23/26

    摘要： In the field of videoendoscopes for medical or industrial use, a videoendoscope has a bispectral optical head comprising a microcamera, white light lighting means and fluorescence light lighting means. The optical head is linked by appropriate electrical and optical connectors to the other elements of the videoendoscope. Preferably, it comprises inexpensive standard elements and is packaged in a single-use sterile packaging. There are different possible embodiments depending on whether the optical head comprises a single sensor or two sensors, depending on whether the device operates in continuous mode or in sequential mode and, finally, depending on whether the light sources are incorporated in the optical head or external thereto, the light being then routed by means of optical fibres.

    摘要翻译： 在用于医疗或工业用途的视频内窥镜领域中，视频内窥镜具有包括微型摄像机，白光照明装置和荧光灯照明装置的双谱光学头。 光头通过适当的电气和光学连接器连接到视频内窥镜的其他元件。 优选地，其包括廉价的标准元件并且包装在一次性无菌包装中。 取决于装置是以连续模式还是以顺序模式操作，取决于光学头是包括单个传感器还是两个传感器，存在不同的可能实施例，最后，取决于光源是否并入光学头或外部 然后光被光纤路由。

    Bi-Spectral Peroperative Optical Probe
    4.
    发明申请
    Bi-Spectral Peroperative Optical Probe 审中-公开
    双光谱全光学探头

    公开(公告)号：US20110190639A1

    公开(公告)日：2011-08-04

    申请号：US13019119

    申请日：2011-02-01

    申请人： Philippe PELTIE ,  Michel BERGER

    发明人： Philippe PELTIE ,  Michel BERGER

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059

    摘要： Optical probes for medical applications are provided. The probe is devised so as to be able to be held in one hand. A basic version of the probe includes: a first excitation lighting source suitable for causing a fluorescence radiation of predetermined substances; a second visible lighting source, the first and the second source being devised so as to illuminate a common zone termed the intervention zone; a first photosensitive matrix sensor; and a second photosensitive matrix sensor. The first and second photosensitive matrix sensors are devised in such a way that, when the optical probe is arranged a predetermined distance from the intervention zone, the image in the visible spectrum of the said zone is formed on the photosensitive surface of the first matrix sensor and the image in the fluorescence spectrum of the said zone is formed on the photosensitive surface of the second sensor. A first variant of the probe includes only a single optical objective, a second variant only a single photosensitive matrix sensor, and a third variant makes it possible to work under polarized light.

    摘要翻译： 提供用于医疗应用的光学探针。 探针被设计成能够一只手握住。 探针的基本版本包括：适于引起预定物质的荧光辐射的第一激发光源; 第二可见光源，设计第一和第二源以照亮被称为介入区的公共区; 第一光敏矩阵传感器; 和第二光敏矩阵传感器。 第一和第二光敏矩阵传感器被设计成使得当光学探针与干涉区域布置预定距离时，所述区域的可见光谱中的图像形成在第一矩阵传感器的感光表面上 并且所述区域的荧光光谱中的图像形成在第二传感器的感光表面上。 探头的第一变型仅包括单一光学物镜，第二变型仅包含单个光敏矩阵传感器，而第三变体使得可以在偏振光下工作。

    Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography
    5.
    发明授权
    Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography 有权
    通过使用荧光光学地成像生物组织的方法，特别是通过层析成像来定义要分析的组织中的感兴趣区域

    公开(公告)号：US07809431B2

    公开(公告)日：2010-10-05

    申请号：US11736333

    申请日：2007-04-17

    申请人： Isabelle Texier-Nogues ,  Philippe Peltie ,  Emilie Heinrich ,  Rolande Blanc

    发明人： Isabelle Texier-Nogues ,  Philippe Peltie ,  Emilie Heinrich ,  Rolande Blanc

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0073 ,  A61B2503/40

    摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography.The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.

    摘要翻译： 本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。 根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1处顺序地激励所述标记，所述标记适于被至少两个波长λ1激发，并且响应于每个波长λ1发射m个同时发射的串联Si 带Bj具有不同的最大波长λ'j，其从一个串联的Si到另一个串联大致相同; 并且检测这些系列Si以从其推导出组织中所述标记的三维位置的估计和/或激发波长λi的组织的平均吸收系数。

    Fluorescence Reflection Imaging Device with Two Wavelengths
    6.
    发明申请
    Fluorescence Reflection Imaging Device with Two Wavelengths 审中-公开
    具有两个波长的荧光反射成像装置

    公开(公告)号：US20090042179A1

    公开(公告)日：2009-02-12

    申请号：US11795975

    申请日：2006-01-20

    申请人： Philippe Peltie ,  Michel Berger ,  Roland Sauze ,  Stephane Bonnet

    发明人： Philippe Peltie ,  Michel Berger ,  Roland Sauze ,  Stephane Bonnet

    IPC分类号： C12Q1/00 ,  G01J3/42 ,  G06T7/40

    CPC分类号： G01N21/64 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638

    摘要： A first light source has a first wavelength corresponding to an excitation wavelength of a fluorophore. The excitation wavelength and an emission wavelength of the fluorophore delineate a predetermined interval. A second light source has a second wavelength offset with respect to the first wavelength so as to be outside said predetermined interval. The offset between the first and second wavelengths is comprised between 30 nm and 100 nm. A camera comprises a filter opaque to the first and second wavelengths and transparent to the emission wavelength and to wavelengths substantially higher than the higher of the first and second wavelengths. The light sources and camera are synchronized to alternately activate one of the light sources and make the camera alternately acquire a fluorescence image and a background noise image.

    摘要翻译： 第一光源具有对应于荧光团的激发波长的第一波长。 荧光团的激发波长和发射波长描绘预定间隔。 第二光源相对于第一波长具有第二波长偏移，以便在所述预定间隔之外。 第一和第二波长之间的偏移在30nm和100nm之间。 照相机包括对第一和第二波长不透明并且对于发射波长透明且对于高于第一和第二波长较高的波长的滤光器。 光源和相机被同步以交替地激活光源中的一个并使相机交替地获取荧光图像和背景噪声图像。

    Optical Device for Measuring the Thickness of an at Least Partially Transparent Medium
    7.
    发明申请
    Optical Device for Measuring the Thickness of an at Least Partially Transparent Medium 有权
    用于测量至少部分透明介质厚度的光学装置

    公开(公告)号：US20080068619A1

    公开(公告)日：2008-03-20

    申请号：US11629355

    申请日：2006-06-24

    申请人： Franck Vial ,  Philippe Peltie ,  Angelo Guiga

    发明人： Franck Vial ,  Philippe Peltie ,  Angelo Guiga

    IPC分类号： G01B11/28

    CPC分类号： B60R16/0237 ,  G01B11/0625

    摘要： The inventive optical device for measuring the thickness of a medium which is at least partially transparent for an incident beam and covers a second medium comprises a laser for generating the light incident beam in such a way that a beam reflected by the first medium surface and a beam scattered by the second medium surface are formed. The device comprises a photosensitive linear array for detecting the reflected beam and the scattered beam and a processing circuit which is connected to the linear array and enables to measure a space between the reflected beam and the scattered beam and to determine the thickness of the first medium according to the measured space. The processing circuit determines a distance between the linear array and the surface of the second medium from the position of at least one beam and corrects the valve of the thickness of the first medium according to the distance.

    摘要翻译： 用于测量入射光束至少部分透明并覆盖第二介质的介质的厚度的本发明的光学装置包括用于产生光入射光束的激光，使得由第一介质表面反射的光束和 形成由第二介质表面散射的光束。 该装置包括用于检测反射光束和散射光束的感光线性阵列和连接到线性阵列并且能够测量反射光束和散射光束之间的空间并且确定第一介质的厚度的处理电路 根据测量的空间。 处理电路从至少一个光束的位置确定线阵列和第二介质表面之间的距离，并根据该距离校正第一介质厚度的阀​​。

    Optical device for measuring the displacement velocity of a first moving element with respect to a second element
    9.
    发明授权
    Optical device for measuring the displacement velocity of a first moving element with respect to a second element 有权
    用于测量第一移动元件相对于第二元件的位移速度的光学装置

    公开(公告)号：US07345745B2

    公开(公告)日：2008-03-18

    申请号：US11629211

    申请日：2005-06-24

    申请人： Viviane Cattin ,  Philippe Peltie ,  Bruno Flament ,  William Fourcault

    发明人： Viviane Cattin ,  Philippe Peltie ,  Bruno Flament ,  William Fourcault

    IPC分类号： G01P3/36

    CPC分类号： G01S17/48 ,  G01P3/68 ,  G01P3/806 ,  G01S7/497 ,  G01S17/58

    摘要： An optical device for measuring the displacement velocity of a first movable element in relation to a second element which is fixed to one of said elements and comprises two lasers transmitting two incident beams towards the other elements. The device including photosensitive linear arrays for front and rear detection which are substantially perpendicular to each other. Additional front and rear photosensitive linear arrays are disposed at a distance from the photosensitive front and rear linear arrays. A processing circuit is connected to the photosensitive linear arrays and determines the longitudinal and/or transversal displacement velocity of the movable element. The circuit also determines the distance between the device and the other element by means of optical triangulation and corrects the longitudinal and/or transversal displacement velocity value according of the said distance.

    摘要翻译： 一种光学装置，用于测量第一可移动元件相对于固定到所述元件之一的第二元件的位移速度，并包括将两个入射光束朝向其它元件透射的两个激光器。 该装置包括基本上彼此垂直的用于前后检测的光敏线性阵列。 附加的前后感光线性阵列设置在与感光前线和后线阵列一定距离处。 处理电路连接到感光线性阵列并确定可移动元件的纵向和/或横向位移速度。 电路还通过光学三角测量法确定器件与另一元件之间的距离，并根据所述距离校正纵向和/或横向位移速度值。

    METHOD OF OPTICALLY IMAGING BIOLOGICAL TISSUES BY USING FLUORESCENCE, IN PARTICULAR FOR DEFINING REGIONS OF INTEREST IN TISSUES TO BE ANALYZED BY TOMOGRAPHY
    10.
    发明申请
    METHOD OF OPTICALLY IMAGING BIOLOGICAL TISSUES BY USING FLUORESCENCE, IN PARTICULAR FOR DEFINING REGIONS OF INTEREST IN TISSUES TO BE ANALYZED BY TOMOGRAPHY 有权
    通过使用荧光光学成像生物组织的方法，特别是用于定义通过TOMOGRAPHA分析的组织中的兴趣区域

    公开(公告)号：US20070249943A1

    公开(公告)日：2007-10-25

    申请号：US11736333

    申请日：2007-04-17

    申请人： Isabelle TEXIER-NOGUES ,  Philippe PELTIE ,  Emilie HEINRICH ,  Rolande BLANC

    发明人： Isabelle TEXIER-NOGUES ,  Philippe PELTIE ,  Emilie HEINRICH ,  Rolande BLANC

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0073 ,  A61B2503/40

    摘要： The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography. The method according to the invention comprises the following steps: a) introducing at least one fluorescent marker into the tissue(s); b) exciting the marker by incident light and detecting emission bands relating to fluorescence emitted by the marker in response to that excitation; then c) analyzing the fluorescence in these emission bands; and  the step b) comprising: sequentially exciting said marker at n different incident excitation wavelengths λi, said marker being adapted to be excited by at least two of the wavelengths λi and to emit in response to each wavelength λi a series Si of m simultaneous emission bands Bj having different maximum wavelengths λ′j that are substantially the same from one series Si to another; and detecting these series Si in order to deduce therefrom an estimate of the three-dimensional location of said marker in the tissue(s) and/or the mean absorption coefficients of the tissue(s) for the excitation wavelengths λi.

    摘要翻译： 本发明涉及一种对至少一个生物组织进行光学成像的方法，特别是通过层析成像来限定要分析的组织的感兴趣区域。 根据本发明的方法包括以下步骤：a）将至少一种荧光标记物引入组织; b）通过入射光激发标记，并响应于该激发检测与标记物发射的荧光相关的发射带; 然后c）分析这些发射带中的荧光; 并且步骤b）包括：在n个不同的入射激发波长λ1上顺序地激发所述标记，所述标记适于被波长λ1中的至少两个激发， 并且响应于具有不同最大波长λ'SUB的m个同时发射带B SUB的每个波长λi的序列S i i i发射。 > j ，其从一个系列S SUB到另一个系列是基本相同的; 并且检测这些系列S i，以便从其推导出组织中所述标记的三维位置的估计和/或组织的平均吸收系数 激发波长λ1。