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公开(公告)号：US07875611B2
公开(公告)日：2011-01-25
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/40 , C07D265/30 , C07D207/04
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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2.发明授权Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics 有权用于心律失常的氨基环烷基肉桂酰胺化合物和作为止痛剂和麻醉剂公开(公告)号：US07687536B2
公开(公告)日：2010-03-30
申请号：US11402228
申请日：2006-04-11
IPC分类号： A61K31/40 , C07D207/04 , C07D207/46
CPC分类号： C07D295/135 , A61K31/40 , C07C2601/08 , C07C2601/14
摘要： Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
摘要翻译： 公开了氨基环烷基肉桂酰胺化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和局部镇痛和麻醉的产生。
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公开(公告)号：US20100029639A1
公开(公告)日：2010-02-04
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/32 , A61K31/5375 , A61K31/40 , C07D207/08 , C07D409/08 , A61P9/00
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US07524879B2
公开(公告)日：2009-04-28
申请号：US11757880
申请日：2007-06-04
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07057053B2
公开(公告)日：2006-06-06
申请号：US11018428
申请日：2004-12-21
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： C07D207/12 , A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US5506257A
公开(公告)日：1996-04-09
申请号：US196865
申请日：1994-02-15
IPC分类号： C07D295/135 , C07D333/54 , C07D333/60 , A61K31/38 , A61K31/40
CPC分类号： C07D295/135 , C07D333/54 , C07D333/60
摘要： The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and instructions for the use of the compounds for the treatment of arrhythmia or for the inducement of local anaesthesia.
摘要翻译： 本发明提供使用氨基环己基酰胺阻断心脏或神经元组织中钠通道的方法。 本发明还提供了包括氨基环己基酰胺的试剂和用于治疗心律失常或诱导局部麻醉的化合物的说明书。
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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US08008342B2
公开(公告)日：2011-08-30
申请号：US12412010
申请日：2009-03-26
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07259184B2
公开(公告)日：2007-08-21
申请号：US11342270
申请日：2006-01-27
申请人： Gregory N Beatch , Bertrand M C Plouvier , Tao Sheng , Michael J A Walker , Richard A Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
发明人： Gregory N Beatch , Bertrand M C Plouvier , Tao Sheng , Michael J A Walker , Richard A Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
IPC分类号： A61K31/4025 , C07D207/12
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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