公开(公告)号：US5344457A

公开(公告)日：1994-09-06

申请号：US12626

申请日：1993-02-02

申请人： Robert M. Pilliar ,  Douglas A. Deporter ,  Phillip A. Watson

发明人： Robert M. Pilliar ,  Douglas A. Deporter ,  Phillip A. Watson

IPC分类号： A61C8/00 ,  A61F2/00 ,  A61F2/30 ,  A61L27/04 ,  A61L27/10 ,  A61L27/32 ,  A61L27/56 ,  A61F2/28 ,  A61C13/10

CPC分类号： A61L27/32 ,  A61C8/0012 ,  A61C8/0018 ,  A61L27/04 ,  A61L27/10 ,  A61L27/56 ,  A61C8/0013 ,  A61F2/30749 ,  A61F2/30767 ,  A61F2002/30332 ,  A61F2002/30405 ,  A61F2002/30433 ,  A61F2220/0008 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2310/00796

摘要： There is disclosed an implant for anchoring in bone and/or fibrous connective tissue and to which a prosthesis such as a dental bridge may be connected through connecting components. The implant is of tapered design defining a wide top portion for connection to the connecting components and a tapered body comprising upper and lower regions. The lower bone-engaging region of the implant is provided with a porous surface into which bone may grow thereby anchoring the implant. The upper region of the implant has a surface suitable for bone attachment which is different from the surface of the lower region. In one embodiment, the upper portion has a larger taper angle than the rest of the implant for increased stability and stress transfer to the surrounding bone. In another embodiment, the surface of the upper region is coated with a bioreactive coating to allow direct bonding of bone and/or soft connective tissue (gingival tissue) thereby inhibiting epithelial migration apically.

摘要翻译： 公开了用于锚固在骨和/或纤维结缔组织中的植入物，并且诸如牙桥的假体可以通过连接部件连接到该植入物上。 植入物具有锥形设计，其限定用于连接到连接部件的宽顶部部分和包括上部和下部区域的锥体。 植入物的下骨接合区域设置有多孔表面，骨可以生长，从而锚固植入物。 植入物的上部区域具有适于不同于下部区域的表面的骨骼附着的表面。 在一个实施例中，上部具有比其余植入物更大的锥角，以增加对周围骨骼的稳定性和应力传递。 在另一个实施方案中，上部区域的表面涂覆有生物反应性涂层，以允许骨和/或软结缔组织（牙龈组织）的直接结合从而抑制顶端上皮迁移。

公开(公告)号：US4206516A

公开(公告)日：1980-06-10

申请号：US858417

申请日：1977-12-07

申请人： Robert M. Pilliar

发明人： Robert M. Pilliar

IPC分类号： A61F2/00 ,  A61F2/30 ,  A61L27/06 ,  A61F1/24 ,  A61F1/00

CPC分类号： A61L27/06 ,  A61F2/30767 ,  A61F2002/30968 ,  A61F2310/00023 ,  A61F2310/00395 ,  A61F2310/00407

摘要： A surgical prosthetic device or implant is disclosed consisting of a coherent metal substrate and a pure metal porous coating. The pure metal porous coating is formed by thermal decomposition of a coating of thermally-decomposable metal compound particles and sintering of the metal particles so formed. The surface of the device or implant is irregular but the porosity is substantially uniformly distributed throughout the coating. The coating is strongly adherent to the substrate and supports the ingrowth of bone tissue for fixation of the device or implant in the body. Such coating also supports the ingrowth of fibrous tissue for the attachment of tendons and ligaments to the device.

摘要翻译： 公开了一种手术假体装置或植入物，其由相干金属基底和纯金属多孔涂层组成。 纯金属多孔涂层通过热分解可热分解的金属化合物颗粒的涂层和如此形成的金属颗粒的烧结而形成。 装置或植入物的表面是不规则的，但孔隙度基本均匀地分布在整个涂层中。 该涂层强烈地附着于基底并且支撑骨组织的向内生长以将该装置或植入物固定在体内。 这种涂层还支持纤维组织的向内生长以将肌腱和韧带附着到装置。

公开(公告)号：US07494614B2

公开(公告)日：2009-02-24

申请号：US10617358

申请日：2003-07-11

申请人： Robert M. Pilliar ,  Jenshong Hong ,  J. Paul Santerre

发明人： Robert M. Pilliar ,  Jenshong Hong ,  J. Paul Santerre

IPC分类号： B29C65/00

CPC分类号： C04B35/447 ,  A61B17/72 ,  A61B17/80 ,  A61B17/866 ,  A61B2017/00004 ,  A61L15/24 ,  A61L15/60 ,  A61L27/12 ,  A61L27/425 ,  A61L27/56 ,  A61L31/123 ,  A61L31/146 ,  C04B35/62665 ,  C04B35/64 ,  C04B38/00 ,  C04B41/009 ,  C04B41/48 ,  C04B41/483 ,  C04B41/83 ,  C04B2111/00836 ,  C04B2235/3201 ,  C04B2235/3206 ,  C04B2235/3212 ,  C04B2235/3217 ,  C04B2235/3232 ,  C04B2235/3244 ,  C04B2235/3251 ,  C04B2235/3272 ,  C04B2235/3275 ,  C04B2235/3279 ,  C04B2235/3281 ,  C04B2235/3418 ,  C04B2235/5436 ,  C04B2235/608 ,  C04B2235/6588 ,  C04B2235/661 ,  C04B2235/76 ,  C04B2235/77 ,  C04B2235/786 ,  C04B2235/94 ,  C04B2235/96 ,  C04B2235/9615 ,  Y10S623/901 ,  C04B2103/0072 ,  C04B41/4888 ,  C08L33/00

摘要： A sintering schedule to allow the reliable formation of inorganic or ceramic materials, exemplified using porous calcium polyphosphate samples to be used for forming novel implants for bone interfacing applications. The key to the successful definition of the process was the determination of the factors affecting the crystallization temperature of the powders that are gravity sintered to form porous samples of desired density and with a pore size range suitable for the particular application. The method involves applying a sintering procedure to a packed amorphous inorganic powder which gives control over densification and includes choosing sintering temperatures and times sequentially that correspond to the inorganic material being amorphous but having a viscosity to develop significant sinter necks between adjacent powder particles by a viscous flow sintering mechanism while maintaining a desired open-pored structure, followed by a second temperature at which crystallization of the packed amorphous inorganic powder occurs and during which slower diffusion-related mechanisms control sinter neck growth and densification to give a substantially crystalline porous, inorganic structure. In addition, interpenetrating phase composites of biodegradable organic polymers throughout the porous calcium polyphosphate samples were formed and resulted in the development of novel composites with attractive strength and toughness. These materials hold promise for formation of biodegradable fracture fixation implants and degradable anchoring systems for temporary stabilization of bone-interfacing implants designed for fixation by bone ingrowth.

摘要翻译： 烧结程序，以允许可靠地形成无机或陶瓷材料，例如使用多孔多磷酸钙样品用于形成用于骨接合应用的新型植入物。 成功确定该方法的关键是确定影响重结晶粉末的结晶温度的因素，以形成所需密度的多孔样品，并具有适合于特定用途的孔径范围。 该方法包括对填充的无定形无机粉末施加烧结程序，其对致密化进行控制，并且包括选择对应于无定形材料的无机材料的烧结温度和时间，但是具有粘性，以通过粘稠度在相邻粉末颗粒之间形成显着的烧结颈部 流动烧结机制，同时保持所需的开孔结构，随后是第二温度，在该第二温度下，发生包装的无定形无机粉末的结晶，并且其中较慢的扩散相关机制控制烧结颈部生长和致密化，得到基本上结晶的多孔，无机结构 。 此外，形成了生物可降解有机聚合物在整个多孔多磷酸钙样品中的互穿相复合材料，并且导致具有诱人的强度和韧性的新型复合材料的开发。 这些材料有望形成可生物降解的骨折固定植入物和可降解的锚定系统，用于临时稳定设计用于骨内向固定的骨界面植入物。