公开(公告)号：US08376982B2

公开(公告)日：2013-02-19

申请号：US12725175

申请日：2010-03-16

申请人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

发明人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

IPC分类号： A61B5/00

CPC分类号： A61B10/0051 ,  A61B5/14546 ,  A61B5/4261 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/54366 ,  Y10T436/25 ,  Y10T436/25125

摘要： An extraction method and apparatus is provided for obtaining quick, safe and highly sensitive testing of a variety of body fluids including saliva, blood, urine or other fluids for drugs of abuse or other analytes. The apparatus includes a latchable extraction wand for obtaining body fluid samples from a subject which is adapted to maximize the portion of the body fluid sample that will go into a graduated bottle containing a buffer solution, and a testing device wherein the sample will be received and into which test strips can be inserted to determine levels of drugs of abuse or other analyte in the sample. In one of the methods of the invention, energy is imparted to the sample and buffer solution, such as by shaking, and this facilitates reduction of sample viscosity, such as by promoting the breakdown of mucins when the sample is saliva.

摘要翻译： 提供一种提取方法和装置，用于对滥用药物或其他分析物质的唾液，血液，尿液或其他液体的各种体液进行快速，安全和高度灵敏的测试。 该装置包括可闩锁的提取棒，用于从受试者获得体液样本，其适于最大化将进入含有缓冲溶液的分级瓶的体液样品的部分;以及测试装置，其中将接收样品， 可以插入测试条以确定样品中滥用药物或其他分析物的水平。 在本发明的一种方法中，例如通过摇动将能量赋予样品和缓冲溶液，并且这有助于样品粘度的降低，例如当样品是唾液时促进粘蛋白的分解。

公开(公告)号：US20070259442A1

公开(公告)日：2007-11-08

申请号：US11827434

申请日：2007-07-12

申请人： Martin Gould ,  Robert Smalley ,  Robert Bernstine

发明人： Martin Gould ,  Robert Smalley ,  Robert Bernstine

IPC分类号： G01N21/00 ,  G01N21/01

CPC分类号： A61B10/007 ,  A61B10/0096 ,  A61B2010/0003 ,  A61B2010/0009 ,  B01L3/5025 ,  B01L2300/0663 ,  G01N33/493

摘要： An assay device for testing of liquid samples for drugs of abuse has a transparent cylindrical container for retaining a liquid sample and a portion of the cylindrical wall is flat. A test strip holder is within the container and is flat so that its front surface corresponds to the flat portion of the container wall. Immunoassay test strips are in pockets on the front face of the strip holder and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then wicks upwardly through the test strip to react with reagents within the test strip.

摘要翻译： 用于测试滥用药物的液体样品的测定装置具有用于保持液体样品的透明圆柱形容器，并且一部分圆柱形壁是平坦的。 测试条保持器在容器内并且是平坦的，使得其前表面对应于容器壁的平坦部分。 免疫测定试纸条位于条带夹的前表面的口袋中，并通过容器壁可见。 每个测试条被封装在具有底部开口的透明袋中，测试条的底部突出通过该底部开口接触容器内的液体样品。 然后液体向上通过测试条，与测试条内的试剂反应。

公开(公告)号：US20100172797A1

公开(公告)日：2010-07-08

申请号：US12725175

申请日：2010-03-16

申请人： Martin GOULD ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

发明人： Martin GOULD ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

IPC分类号： G01N21/01 ,  G01N33/48 ,  A61B5/00

CPC分类号： A61B10/0051 ,  A61B5/14546 ,  A61B5/4261 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/54366 ,  Y10T436/25 ,  Y10T436/25125

摘要： An extraction method and apparatus is provided for obtaining quick, safe and highly sensitive testing of a variety of body fluids including saliva, blood, urine or other fluids for drugs of abuse or other analytes. The apparatus includes a latchable extraction wand for obtaining body fluid samples from a subject which is adapted to maximize the portion of the body fluid sample that will go into a graduated bottle containing a buffer solution, and a testing device wherein the sample will be received and into which test strips can be inserted to determine levels of drugs of abuse or other analyte in the sample. In one of the methods of the invention, energy is imparted to the sample and buffer solution, such as by shaking, and this facilitates reduction of sample viscosity, such as by promoting the breakdown of mucins when the sample is saliva.

摘要翻译： 提供一种提取方法和装置，用于对滥用药物或其他分析物质的唾液，血液，尿液或其他液体的各种体液进行快速，安全和高度灵敏的测试。 该装置包括可闩锁的提取棒，用于从受试者获得体液样本，其适于最大化将进入含有缓冲溶液的分级瓶的体液样品的部分;以及测试装置，其中将接收样品， 可以插入测试条以确定样品中滥用药物或其他分析物的水平。 在本发明的一种方法中，例如通过摇动将能量赋予样品和缓冲溶液，并且这有助于样品粘度的降低，例如当样品是唾液时促进粘蛋白的分解。

公开(公告)号：US07695953B2

公开(公告)日：2010-04-13

申请号：US11621261

申请日：2007-01-09

申请人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

发明人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

IPC分类号： G01N33/533

CPC分类号： A61B10/0051 ,  A61B5/14546 ,  A61B5/4261 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/54366 ,  Y10T436/25 ,  Y10T436/25125

摘要： An extraction method and apparatus is provided for obtaining quick, safe and highly sensitive testing of any of a variety of body fluids including saliva, blood, urine or other fluids for drugs of abuse or other analytes. The apparatus includes a latchable extraction wand for obtaining body fluid samples from a subject which is adapted to maximize the portion of the body fluid sample that will go into a graduated bottle containing a buffer solution, and a testing device wherein the sample will be received and into which test strips can be inserted to determine levels of drugs of abuse or other analyte in the sample. In one of the methods of the invention, energy is imparted to the sample and buffer solution, such as by shaking, and this facilitates the reduction of sample viscosity, such as by promoting the breakdown of mucins when the sample is saliva.

摘要翻译： 提供了一种提取方法和装置，用于对滥用药物或其他分析物的唾液，血液，尿液或其他液体中的任何一种体液进行快速，安全和高度灵敏的测试。 该装置包括可闩锁的提取棒，用于从受试者获得体液样本，其适于最大化将进入含有缓冲溶液的分级瓶的体液样品的部分;以及测试装置，其中将接收样品， 可以插入测试条以确定样品中滥用药物或其他分析物的水平。 在本发明的一种方法中，例如通过摇动将能量赋予样品和缓冲溶液，这有利于样品粘度的降低，例如当样品是唾液时促进粘蛋白的分解。

公开(公告)号：US06678607B2

公开(公告)日：2004-01-13

申请号：US10153107

申请日：2002-05-22

申请人： Mark Akins ,  Scott Thompson ,  Robert Smalley, II ,  Daniel G. Showalter ,  Bryan Williams ,  Greg Smith ,  Eric Holloway

发明人： Mark Akins ,  Scott Thompson ,  Robert Smalley, II ,  Daniel G. Showalter ,  Bryan Williams ,  Greg Smith ,  Eric Holloway

IPC分类号： G06F1900

CPC分类号： F01M1/20

摘要： A system, method and apparatus are disclosed for creating a signal that indicates the pressure of the fluid in an engine. A switch or sensor determines whether the actual pressure is greater or less than a threshold pressure. If the actual pressure is less than the threshold pressure, a sensed pressure (e.g., the output of a pressure sensor) is used. If the sensed pressure is greater than the threshold pressure, then the output is derived from an estimate of the fluid pressure, where the estimate is based on other operating parameters of the engine. The output signal can be used as an input to a display visible by an operator, controller logs, diagnostic systems, and the like.

摘要翻译： 公开了一种用于创建指示发动机中的流体的压力的信号的系统，方法和装置。 开关或传感器确定实际压力是否大于或小于阈值压力。 如果实际压力小于阈值压力，则使用感测压力（例如，压力传感器的输出）。 如果感测到的压力大于阈值压力，则输出是从流体压力的估计得出的，其中估计基于发动机的其它操作参数。 输出信号可以用作操作者，控制器日志，诊断系统等可见的显示器的输入。

公开(公告)号：US20060292036A1

公开(公告)日：2006-12-28

申请号：US11443050

申请日：2006-05-31

申请人： Martin Gould ,  Robert Bernstine ,  Robert Smalley ,  Jacqueline Gale

发明人： Martin Gould ,  Robert Bernstine ,  Robert Smalley ,  Jacqueline Gale

IPC分类号： G01N31/22

CPC分类号： A61B10/0051 ,  A61B2010/0003 ,  A61B2010/0009 ,  B01L3/5023 ,  B01L3/5029 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/065 ,  B01L2400/0683

摘要： A saliva sample testing device has a base housing upon which is mounted an upper housing. The base housing has a drawer structure in which are formed reaction wells for receiving fluid specimens. The drawer may be slidable or pivotable out of this base housing to provide access to the reaction wells. In a modification the reaction wells are formed in the top surface of the base housing and the upper housing is tiltable upon or detached from the base housing to provide access to the reaction wells.

摘要翻译： 唾液样本测试装置具有底座外壳，其上安装有上壳体。 基座壳体具有抽屉结构，其中形成有用于接收流体试样的反应井。 抽屉可以可滑动或可枢转地离开该基座外壳以提供对反应井的通路。 在一个修改中，反应孔形成在基座壳体的顶表面中，并且上壳体可以从基座壳体倾斜或分离，以提供对反应井的通路。

公开(公告)号：US08287809B2

公开(公告)日：2012-10-16

申请号：US11760977

申请日：2007-06-11

申请人： Martin Gould ,  Robert Smalley ,  Robert Bernstine

发明人： Martin Gould ,  Robert Smalley ,  Robert Bernstine

IPC分类号： G01N15/06

CPC分类号： A61B10/0051

摘要： A method and device are provided for stimulating and increasing the production of saliva during immunoassay tests for drugs or other analytes wherein a scent or odor capable of stimulating saliva production is incorporated into a device for obtaining an oral sample from a test subject. The scent or odor may be impregnated into the oral sample collection device or may be part of an attachment to such a device, and the scent or odor is disposed in such a manner so as to maximize the exposure of the scent to the test subject and thus stimulate the production of saliva. The method and device of the invention are advantageous because the increased production of saliva will facilitate the testing of an oral sample for drugs or other analytes and will increase the likelihood of obtaining a complete and accurate result.

摘要翻译： 提供了一种方法和装置，用于在用于药物或其他分析物的免疫测定试验期间刺激和增加唾液的产生，其中将能够刺激唾液产生的气味或气味并入到用于从测试对象获得口服样品的装置中。 气味或气味可以浸渍到口腔样品采集装置中，或者可以是与这种装置的附件的一部分，并且气味或气味以如下方式设置，以便最大限度地将香味暴露于测试对象， 从而刺激唾液的产生。 本发明的方法和装置是有利的，因为唾液的增加的产量将有助于口服药物或其他分析物的测试，并且将增加获得完整和准确结果的可能性。

公开(公告)号：US20080305548A1

公开(公告)日：2008-12-11

申请号：US11760977

申请日：2007-06-11

申请人： Martin Gould ,  Robert Smalley ,  Rob Bernstine

发明人： Martin Gould ,  Robert Smalley ,  Rob Bernstine

IPC分类号： G01N33/50 ,  A61B10/00 ,  B01J19/00

CPC分类号： A61B10/0051

摘要： A method and device are provided for stimulating and increasing the production of saliva during immunoassay tests for drugs or other analytes wherein a scent or odor capable of stimulating saliva production is incorporated into a device for obtaining an oral sample from a test subject. The scent or odor may be impregnated into the oral sample collection device or may be part of an attachment to such a device, and the scent or odor is disposed in such a manner so as to maximize the exposure of the scent to the test subject and thus stimulate the production of saliva. The method and device of the invention are advantageous because the increased production of saliva will facilitate the testing of an oral sample for drugs or other analytes and will increase the likelihood of obtaining a complete and accurate result.

摘要翻译： 提供了一种方法和装置，用于在用于药物或其他分析物的免疫测定试验期间刺激和增加唾液的产生，其中将能够刺激唾液产生的气味或气味并入到用于从测试对象获得口服样品的装置中。 气味或气味可以浸渍到口腔样品采集装置中，或者可以是与这种装置的附件的一部分，并且气味或气味以如下方式设置，以便最大限度地将香味暴露于测试对象， 从而刺激唾液的产生。 本发明的方法和装置是有利的，因为唾液的增加的产量将有助于口服药物或其他分析物的测试，并且将增加获得完整和准确结果的可能性。

公开(公告)号：US20080166820A1

公开(公告)日：2008-07-10

申请号：US11621261

申请日：2007-01-09

申请人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

发明人： Martin Gould ,  Robert Smalley ,  Robert Bernstine ,  Jackie Gale ,  John Donovan

IPC分类号： G01N33/566 ,  B01J19/00 ,  B01L11/00 ,  G01N1/28 ,  G01N21/75

CPC分类号： A61B10/0051 ,  A61B5/14546 ,  A61B5/4261 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/54366 ,  Y10T436/25 ,  Y10T436/25125

摘要： An extraction method and apparatus is provided for obtaining quick, safe and highly sensitive testing of any of a variety of body fluids including saliva, blood, urine or other fluids for drugs of abuse or other analytes. The apparatus includes a latchable extraction wand for obtaining body fluid samples from a subject which is adapted to maximize the portion of the body fluid sample that will go into a graduated bottle containing a buffer solution, and a testing device wherein the sample will be received and into which test strips can be inserted to determine levels of drugs of abuse or other analyte in the sample. In one of the methods of the invention, energy is imparted to the sample and buffer solution, such as by shaking, and this facilitates the reduction of sample viscosity, such as by promoting the breakdown of mucins when the sample is saliva.

摘要翻译： 提供了一种提取方法和装置，用于对滥用药物或其他分析物的唾液，血液，尿液或其他液体中的任何一种体液进行快速，安全和高度灵敏的测试。 该装置包括可闩锁的提取棒，用于从受试者获得体液样本，其适于最大化将进入含有缓冲溶液的分级瓶的体液样品的部分;以及测试装置，其中将接收样品， 可以插入测试条以确定样品中滥用药物或其他分析物的水平。 在本发明的一种方法中，例如通过摇动将能量赋予样品和缓冲溶液，这有利于样品粘度的降低，例如当样品是唾液时促进粘蛋白的分解。