公开(公告)号：US08680247B2

公开(公告)日：2014-03-25

申请号：US12668965

申请日：2008-07-17

Applicant: Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

Inventor： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

IPC: C07K16/30 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46

CPC classification number: C07K16/28 ,  A61K39/00 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.

Abstract translation: 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。

公开(公告)号：US08609816B2

公开(公告)日：2013-12-17

申请号：US12092866

申请日：2006-12-08

Applicant: Alan J. Korman ,  Mark J. Selby ,  Li-Sheng Lu ,  Alison Witte ,  Haichun Huang

Inventor： Alan J. Korman ,  Mark J. Selby ,  Li-Sheng Lu ,  Alison Witte ,  Haichun Huang

IPC: C07K16/00 ,  C07K17/00 ,  C12P21/08

CPC classification number: C07K16/2827 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/55 ,  C12N15/00 ,  C12N15/09 ,  C12N15/62

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Abstract translation: 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症的方法。

公开(公告)号：US08448001B1

公开(公告)日：2013-05-21

申请号：US12715612

申请日：2010-03-02

Applicant: Jun Zhu ,  Ian Swarbrick ,  Joseph Jun Cao ,  Sheng Lu ,  Pantas Sutardja

Inventor： Jun Zhu ,  Ian Swarbrick ,  Joseph Jun Cao ,  Sheng Lu ,  Pantas Sutardja

IPC: G06F1/00 ,  G06F1/32 ,  G06F1/26

CPC classification number: G06F1/3206 ,  G06F1/3209 ,  G06F1/3237 ,  G06F1/3287 ,  Y02D10/128 ,  Y02D10/171

Abstract: A system includes a first device, a second device, and a main power management module. The first device is configured to communicate with a system bus. The second device is configured to communicate with the system bus. The second device includes a device power management module configured to manage power states of the second device. The main power management module is configured to manage power consumption of the second device independently of the first device by selectively supplying power and clock signals to the second device based on the power states of the second device. The main power management module and the device power management module each comprise a power handshake interface. The main power management module communicates with the device power management module via a power management bus using the power handshake interface.

Abstract translation: 系统包括第一设备，第二设备和主电源管理模块。 第一个设备被配置为与系统总线进行通信。 第二个设备被配置为与系统总线进行通信。 第二设备包括被配置为管理第二设备的电源状态的设备电源管理模块。 主电源管理模块被配置为基于第二设备的电源状态选择性地向第二设备提供电力和时钟信号来管理与第一设备无关的功率消耗。 主电源管理模块和设备电源管理模块各自包括电源握手接口。 主电源管理模块通过使用电源握手接口的电源管理总线与设备电源管理模块进行通信。

公开(公告)号：US20120133153A1

公开(公告)日：2012-05-31

申请号：US12955916

申请日：2010-11-30

Applicant: Hsin-Jen LI ,  Shin-Sheng LU

Inventor： Hsin-Jen LI ,  Shin-Sheng LU

IPC: F03G5/06

CPC classification number: F03G5/06

Abstract: A pedal power generating device includes a base having two supporting arms upwardly extending therefrom. The base has a gearbox mounted thereon. A pedal assembly is mounted between the two supporting arms. The pedal assembly has a pedal, a supporter extending from the pedal, a connecting rod assembled with the supporter and connected to the gearbox, and a twist spring mounted between the pedal and the two supporting arms. A transmitting assembly is mounted in the gearbox. The transmitting assembly includes a driver, a first gear train engaged with the driver, a second gear train engaged with the first gear train, and a steering gear set simultaneously engaging with the first gear train and the second gear train. A generator is mounted adjacent to the gearbox, and the generator has a rotor engaged with the second gear train.

Abstract translation: 踏板发电装置包括具有从其向上延伸的两个支撑臂的底座。 基座上安装有齿轮箱。 踏板组件安装在两个支撑臂之间。 踏板组件具有踏板，从踏板延伸的支撑件，与支撑件组装并连接到齿轮箱的连杆，以及安装在踏板和两个支撑臂之间的扭簧。 传动组件安装在变速箱中。 传动组件包括一个驱动器，一个与该驱动器接合的第一齿轮系，一个与第一齿轮系啮合的第二齿轮系，以及与第一齿轮系和第二齿轮系同时啮合的转向齿轮组。 发电机安装在齿轮箱附近，并且发电机具有与第二齿轮系啮合的转子。

公开(公告)号：US20120094334A1

公开(公告)日：2012-04-19

申请号：US13332523

申请日：2011-12-21

Applicant: Hsu-Chou Hsiao ,  Ting-Sheng Lu ,  Han-Ken Chen ,  Jinn-Tsyy Lai ,  Fwu-Lin Lee ,  Chung-Liang Chu ,  Chii-Cherng Liao

Inventor： Hsu-Chou Hsiao ,  Ting-Sheng Lu ,  Han-Ken Chen ,  Jinn-Tsyy Lai ,  Fwu-Lin Lee ,  Chung-Liang Chu ,  Chii-Cherng Liao

IPC: C12P19/04

CPC classification number: C12P19/04 ,  C12M27/06

Abstract: A technique for producing microbial cellulose is provided, including: preparing a liquid medium for microbial cultivation in a container; horizontally rotating multiple hollow tubes that are fitted together or separated from one another, so that each of the hollow tubes is alternately partially immersed in the liquid medium and partially exposed above the horizontal surface of the liquid medium; wherein each of the hollow tubes has a rough outer surface and a smooth inner surface, so as to allow microorganisms to form microbial cellulose on the outer surface of each hollow tube, as well as forming sheets of microbial cellulose on the horizontal surface of the liquid medium not being disturbed by the hollow tubes, and removing the microbial cellulose from the outer surfaces of the hollow tubes in order to obtain tubular microbial cellulose. In addition, the sheets of microbial cellulose are also harvested from the liquid medium.

Abstract translation: 提供了一种生产微生物纤维素的技术，包括：在容器中制备用于微生物培养的液体培养基; 水平旋转多个中空管，它们彼此装配在一起或分离，使得每个中空管交替地部分地浸没在液体介质中并部分地暴露在液体介质的水平表面之上; 其中每个中空管具有粗糙的外表面和平滑的内表面，以便允许微生物在每个中空管的外表面上形成微生物纤维素，以及在液体的水平表面上形成微生物纤维素片 介质不被中空管扰乱，并从中空管的外表面除去微生物纤维素，以获得管状微生物纤维素。 此外，微生物纤维素片也从液体培养基中收获。

公开(公告)号：US20110191365A1

公开(公告)日：2011-08-04

申请号：US12697845

申请日：2010-02-01

Applicant: Boas Betzler ,  Xing Fang ,  Neil A. Katz ,  Dong Jun Lan ,  Sheng Lu ,  Meng Ye ,  Zi Yu Zhu

Inventor： Boas Betzler ,  Xing Fang ,  Neil A. Katz ,  Dong Jun Lan ,  Sheng Lu ,  Meng Ye ,  Zi Yu Zhu

IPC: G06F17/30

CPC classification number: G06F17/30

Abstract: A system and method enabling the search for a three-dimensional virtual world object across the universe of virtual worlds by utilizing a two-step search process to first identify the object and second, to actively locate and generate a URI to all presently manifest instances of that object.

Abstract translation: 一种通过利用两步搜索过程来首先识别该对象，从而能够跨虚拟世界范围搜索三维虚拟世界对象的系统和方法，其次，主动定位并生成到所有当前显示的实例的URI 那个对象。

公开(公告)号：US20110107329A1

公开(公告)日：2011-05-05

申请号：US12613197

申请日：2009-11-05

Applicant: Boas Betzler ,  Xing Fang ,  Neil A. Katz ,  Sheng Lu ,  Meng Ye ,  Zi Y. Zhu

Inventor： Boas Betzler ,  Xing Fang ,  Neil A. Katz ,  Sheng Lu ,  Meng Ye ,  Zi Y. Zhu

IPC: G06F9/455

CPC classification number: G06F9/4411 ,  G06F9/455 ,  G06F9/5077 ,  G06T19/006 ,  G09G5/14

Abstract: The present invention describes a method and system for governing a physical device or application service in a real world through a virtual device in a virtual world. The physical device or application service registers at least one virtual adaptor of the physical device or application service to a virtual device broker. A user creates or composes the virtual device with the at least one virtual adaptor in the virtual device broker. The user commands to the virtual device through a user interface of the virtual device. The at least one virtual adaptor in the virtual device translates the command to a controlling signal to the physical device or application service. The controlling signal operates the physical device or application service according to the command to the virtual device.

Abstract translation: 本发明描述了一种用于通过虚拟世界中的虚拟设备来管理现实世界中的物理设备或应用服务的方法和系统。 物理设备或应用服务将物理设备或应用服务的至少一个虚拟适配器注册到虚拟设备代理。 用户使用虚拟设备代理中的至少一个虚拟适配器创建或组合虚拟设备。 用户通过虚拟设备的用户界面向虚拟设备发送命令。 虚拟设备中的至少一个虚拟适配器将命令转换为物理设备或应用服务的控制信号。 控制信号根据虚拟设备的命令操作物理设备或应用服务。

公开(公告)号：US07890578B2

公开(公告)日：2011-02-15

申请号：US12016549

申请日：2008-01-18

Applicant: Long Cheng ,  Xing Fang ,  Dong Jun Lan ,  Sheng Lu ,  Qingbo Wang ,  Meng Ye

Inventor： Long Cheng ,  Xing Fang ,  Dong Jun Lan ,  Sheng Lu ,  Qingbo Wang ,  Meng Ye

IPC: G06F15/16

CPC classification number: G06F17/30905 ,  H04L67/02

Abstract: A method for controlling display of a web page on the client, the contents in said web page being assigned different priorities, includes sending an access request for the web page from the client to the server; in response to said access request, the server sending controllers for implementing prioritization of said contents in the web page to the client, and the controllers retrieving the web page contents the server according to the priority order thereof for display. With the system and method, it is possible to prioritize different contents in a web page and to ensure contents with higher priority are downloaded and displayed earlier than those with lower priority, and thereby avoiding the disadvantage of multi-thread parallel download in the prior art.

Abstract translation: 一种用于控制客户端上的网页的显示的方法，所述网页中的内容被分配不同的优先级，包括从客户端向服务器发送网页的访问请求; 响应于所述访问请求，服务器发送控制器，用于将网页中的所述内容的优先级排列到客户端，并且检索网页的控制器根据其优先级顺序对服务器进行内容显示。 利用系统和方法，可以在网页中对不同内容进行优先级排序，并且确保比具有较低优先级的内容更早地下载和显示具有较高优先级的内容，从而避免了现有技术中的多线程并行下载的缺点 。

公开(公告)号：US20100124009A1

公开(公告)日：2010-05-20

申请号：US12494316

申请日：2009-06-30

Applicant: HUA JIANG ,  ZHAN-SHENG LU

Inventor： HUA JIANG ,  ZHAN-SHENG LU

IPC: G06F1/16 ,  H05K7/00

CPC classification number: G06F1/1679 ,  G06F1/162 ,  G06F1/1681 ,  G06F2200/1614

Abstract: A notebook computer includes a main body, two connecting assemblies, and a display. The main body comprises an upper surface and two first joint members disposed on two corners of the upper surface. Each of the connecting assemblies includes an arm, a connecting shaft, and a stop cover. One end of the arm is rotatably connected to a first joint member. The connecting shaft is perpendicularly is connected to the arm, and adjacent to a distal end of the arm from the first joint member. The stop cover is rotatably disposed on the distal end. The display defines a pair of axle holes at one sidewall. The display is disposed between the two arms of the two connecting assemblies, and each connecting shaft of each arm is rotatably inserted in the axle hole

Abstract translation: 笔记本电脑包括主体，两个连接组件和显示器。 主体包括上表面和设置在上表面的两个角上的两个第一接合构件。 每个连接组件包括臂，连接轴和止动盖。 臂的一端可旋转地连接到第一接头构件。 连接轴垂直地连接到臂，并且与第一接头构件的臂的远端相邻。 止动盖可旋转地设置在远端上。 显示器在一个侧壁处限定一对轴孔。 显示器设置在两个连接组件的两个臂之间，每个臂的每个连接轴可旋转地插入轴孔中

公开(公告)号：US20100074337A1

公开(公告)日：2010-03-25

申请号：US12557252

申请日：2009-09-10

Applicant: Yi Zhi Gao ,  Jia Jun Liu ,  Xing Liu ,  Bao Sheng Lu ,  Jia Wang

Inventor： Yi Zhi Gao ,  Jia Jun Liu ,  Xing Liu ,  Bao Sheng Lu ,  Jia Wang

IPC: H04N7/26

CPC classification number: H04N19/436 ,  H04N19/174 ,  H04N19/176 ,  H04N19/61

Abstract: A video stream encoding apparatus and method therefore is herein described. The video stream encoding apparatus includes a divider for dividing a frame in a video stream into a plurality of processing units, each processing unit including a plurality of macro-blocks; and an encoder for encoding the plurality of macro-blocks in each processing unit in parallel. The same quantization parameters are used for respective macro-blocks in the same processing unit in the quantization of the encoder. By the apparatus and the method of the invention, dependencies between macro-blocks are broken, and the precision of high rate controlling is kept while encoding the respective macro-blocks in parallel.

Abstract translation: 因此，在此描述视频流编码设备和方法。 视频流编码装置包括用于将视频流中的帧划分成多个处理单元的分频器，每个处理单元包括多个宏块; 以及并行地对每个处理单元中的多个宏块进行编码的编码器。 在编码器的量化中，相同处理单元中的相应宏块使用相同的量化参数。 通过本发明的装置和方法，宏块之间的依赖关系被破坏，并且在对相应的宏块进行并行编码的同时保持高速率控制的精度。