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1.发明申请POLYVALENT, PRIMARY HIV-1 GLYCOPROTEIN DNA VACCINES AND VACCINATION METHODS 审中-公开多肽，主要HIV-1糖蛋白DNA疫苗和疫苗接种方法公开(公告)号：US20110171258A1
公开(公告)日：2011-07-14
申请号：US13020492
申请日：2011-02-03
申请人： Shan Lu , Shixia Wang , Ranajit Pal , Vaniambadi Kalyanaraman , Stephen Charles Whitney , Tim Keen , Balachandran Nair , Phillip Markham
发明人： Shan Lu , Shixia Wang , Ranajit Pal , Vaniambadi Kalyanaraman , Stephen Charles Whitney , Tim Keen , Balachandran Nair , Phillip Markham
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55577 , A61K2039/57 , A61K2039/70 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided.
摘要翻译： 公开了用于诱导针对HIV的免疫应答的多价，一次分离的核酸组合物。 本文描述的组合物和方法是用于编码一种或多种不同HIV包膜糖蛋白的DNA组合物。 DNA组合物可编码HIV Gag蛋白。 编码一种或多种HIV蛋白质的DNA是由不同HIV主要群体遗传进化枝和/或不同蛋白质的初级分离物DNA产生的不同核酸（例如DNA质粒）的组合。 公开了用于诱导针对HIV的免疫应答的HIV蛋白质组合物。 提供了在施用DNA组合物之后使用蛋白质组合物作为增强剂的方法。
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2.发明授权Recombinant HIV-1 gp120 immunogen with three different V3 loops from viruses of different clades 有权重组HIV-1 gp120免疫原与不同进化枝病毒的三个不同的V3环公开(公告)号：US07847085B2
公开(公告)日：2010-12-07
申请号：US11772760
申请日：2007-07-02
申请人： Susan Zolla-Pazner , Shan Lu , Shixia Wang
发明人： Susan Zolla-Pazner , Shan Lu , Shixia Wang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , C07K2319/00 , C12N2740/16122 , C12N2740/16134
摘要： A novel immunogenic HIV-1 Env, particularly gp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each replacement V3 loop is a consensus sequence of V3 of a different clade. Such constructs are useful as immunogens as each presents three independent V3 epitopes, so that the immunized subject generates a more broadly reactive neutralizing antibody response than with conventional gp120 or V3 DNA or polypeptide immunogens. Also disclosed are methods of using the DNA construct to immunize a mammal, preferably a human, particularly in a priming regiment in which the DNA immunogen is followed by administration of a V3 fusion protein boosting immunogen.
摘要翻译： 公开了一种新型免疫原性HIV-1Env，特别是gp120，DNA构建体，其中V1 / V2环和V4环或所有三个可变环（包括V3）被V3序列替代，每个V3序列来自不同的 病毒分离株。 优选地，每个替换V3环是不同进化枝的V3的共有序列。 这样的构建体可用作免疫原，因为每个呈现三个独立的V3表位，使得免疫受试者比常规gp120或V3 DNA或多肽免疫原产生更广泛的反应性中和抗体应答。 还公开了使用DNA构建体免疫哺乳动物，优选人的方法，特别是在其中DNA免疫原之后是施用V3融合蛋白增强免疫原的引发团中。
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3.发明授权Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods 有权多价，初级HIV-1糖蛋白DNA疫苗和疫苗接种方法公开(公告)号：US07901690B2
公开(公告)日：2011-03-08
申请号：US10728195
申请日：2003-12-03
申请人： Shan Lu , Shixia Wang , Ranajit Pal , Vaniambadi Kalyanaraman , Stephen Charles Whitney , Tim Keen , Balachandran Nair , Phillip Markham
发明人： Shan Lu , Shixia Wang , Ranajit Pal , Vaniambadi Kalyanaraman , Stephen Charles Whitney , Tim Keen , Balachandran Nair , Phillip Markham
IPC分类号： A61K39/21 , A61K39/295 , C12N15/00 , C12P15/09
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55577 , A61K2039/57 , A61K2039/70 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The composition and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods fro using the protein compositions as boosts following administration of the DNA compositions are provided.
摘要翻译： 公开了用于诱导针对HIV的免疫应答的多价，一次分离的核酸组合物。 本文描述的组合物和方法是用于编码一种或多种不同HIV包膜糖蛋白的DNA组合物。 DNA组合物可编码HIV Gag蛋白。 编码一种或多种HIV蛋白质的DNA是由不同HIV主要群体遗传进化枝和/或不同蛋白质的初级分离物DNA产生的不同核酸（例如DNA质粒）的组合。 公开了用于诱导针对HIV的免疫应答的HIV蛋白质组合物。 提供了在施用DNA组合物之后使用蛋白质组合物作为增强剂的方法。
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公开(公告)号：US20070270361A1
公开(公告)日：2007-11-22
申请号：US10565314
申请日：2004-08-04
申请人： Shan Lu , Te-Hui Chou , Shixia Wang
发明人： Shan Lu , Te-Hui Chou , Shixia Wang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , A61K39/42 , A61K2039/53 , C12N2770/20022 , C12N2770/20034
摘要： Codon-optimized nucleic acids, proteins, vaccines, and antibodies are provided herein.
摘要翻译： 密码子优化的核酸，蛋白质，疫苗和抗体在本文中提供。
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5.发明申请Recombinant HIV-1 gp120 Immunogen with Three Different V3 Loops from Viruses of Different Clades 有权重组HIV-1 gp120免疫原与不同来源的病毒的三个不同的V3环公开(公告)号：US20080095791A1
公开(公告)日：2008-04-24
申请号：US11772760
申请日：2007-07-02
申请人： Susan Zolla-Pazner , Shan Lu , Shixia Wang
发明人： Susan Zolla-Pazner , Shan Lu , Shixia Wang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , C07K2319/00 , C12N2740/16122 , C12N2740/16134
摘要： A novel immunogenic HIV-1 Env, particularly gp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each replacement V3 loop is a consensus sequence of V3 of a different clade. Such constructs are useful as immunogens as each presents three independent V3 epitopes, so that the immunized subject generates a more broadly reactive neutralizing antibody response than with conventional gp120 or V3 DNA or polypeptide immunogens. Also disclosed are methods of using the DNA construct to immunize a mammal, preferably a human, particularly in a priming regiment in which the DNA immunogen is followed by administration of a V3 fusion protein boosting immunogen.
摘要翻译： 公开了一种新型免疫原性HIV-1Env，特别是gp120，DNA构建体，其中V1 / V2环和V4环或所有三个可变环（包括V3）被V3序列替代，每个V3序列来自不同的 病毒分离株。 优选地，每个替换V3环是不同进化枝的V3的共有序列。 这样的构建体可用作免疫原，因为每个呈现三个独立的V3表位，使得免疫受试者比常规gp120或V3 DNA或多肽免疫原产生更广泛的反应性中和抗体应答。 还公开了使用DNA构建体免疫哺乳动物，优选人的方法，特别是在其中DNA免疫原之后是施用V3融合蛋白增强免疫原的引发团中。
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6.发明授权Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and scaffold proteins containing said peptide 有权包含呈递HIV-1 GP120 3074mAb表位的修饰环肽和含有所述肽的支架蛋白的免疫原性多肽公开(公告)号：US09534020B2
公开(公告)日：2017-01-03
申请号：US13876918
申请日：2011-09-28
申请人： Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
发明人： Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
IPC分类号： C07K14/005 , C07K7/08 , A61K39/21 , C07K14/00 , C07K14/245 , C07K14/28 , A61K39/12 , A61K39/00
CPC分类号： C07K14/001 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55555 , A61K2039/6037 , C07K7/08 , C07K14/005 , C07K14/245 , C07K14/28 , C12N2740/16034
摘要： The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
摘要翻译： 本发明涉及重组免疫原性多肽。 多肽包括插入免疫原性支架蛋白的环肽。 环多肽具有呈现HIV gp120蛋白的3074 mAb或2219/2557 mAb靶向表位的氨基酸序列，而不是HIV gp120蛋白的其他已知表位。 当用作免疫原时，多肽诱导抗体应答，其分别以与针对3074mAb-或2219 / 2557mAb靶向表位观察到的模式相似的方式中和异源HIV-1病毒。 还公开了含有免疫原性多肽的药物组合物及其制备和使用方法。
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7.发明申请IMMUNOGENIC POLYPEPTIDES HAVING AN IMMUNOGENIC SCAFFOLD PROTEIN AND A LOOP PEPTIDE, PRESENTING A 3074- OR 2219/2557- MONOCLONAL ANTIBODY-TARGETED EPITOPE, WHICH IS PRESENT IN THE HIV GP120 PROTEIN 有权具有免疫原性SCAFFOLD蛋白和环腺苷的免疫多肽具有存在于HIV GP120蛋白中的3074-或2219 / 2557-单克隆抗体靶向抗原决定簇公开(公告)号：US20130287804A1
公开(公告)日：2013-10-31
申请号：US13876918
申请日：2011-09-28
申请人： Timothy Cardozo , Xian-peng Kong , Susan Zolla-Pazner , Abraham Pinter , Chavdar Krachmarov , Shan Lu , Shixia Wang , Maxim Totrov
发明人： Timothy Cardozo , Xian-peng Kong , Susan Zolla-Pazner , Abraham Pinter , Chavdar Krachmarov , Shan Lu , Shixia Wang , Maxim Totrov
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55555 , A61K2039/6037 , C07K7/08 , C07K14/005 , C07K14/245 , C07K14/28 , C12N2740/16034
摘要： The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
摘要翻译： 本发明涉及重组免疫原性多肽。 多肽包括插入免疫原性支架蛋白的环肽。 环多肽具有呈现HIV gp120蛋白的3074 mAb或2219/2557 mAb靶向表位的氨基酸序列，而不是HIV gp120蛋白的其他已知表位。 当用作免疫原时，多肽诱导抗体应答，其分别以与针对3074mAb-或2219 / 2557mAb靶向表位观察到的模式相似的方式中和异源HIV-1病毒。 还公开了含有免疫原性多肽的药物组合物及其制备和使用方法。
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公开(公告)号：US20090291472A1
公开(公告)日：2009-11-26
申请号：US12509670
申请日：2009-07-27
申请人： Shan Lu , Shixia Wang
发明人： Shan Lu , Shixia Wang
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , Y10S514/888
摘要： Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
摘要翻译： 编码流感多肽的密码子优化的核酸以及用于诱导免疫应答的核酸和多肽的用途在此提供。
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公开(公告)号：US07566454B2
公开(公告)日：2009-07-28
申请号：US11362617
申请日：2006-02-24
申请人： Shan Lu , Shixia Wang
发明人： Shan Lu , Shixia Wang
IPC分类号： A61K39/12 , A61K39/145 , A61K31/00 , A61K38/00 , A61K31/70
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , Y10S514/888
摘要： Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
摘要翻译： 编码流感多肽的密码子优化的核酸以及用于诱导免疫应答的核酸和多肽的用途在此提供。
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公开(公告)号：US20060217338A1
公开(公告)日：2006-09-28
申请号：US11362617
申请日：2006-02-24
申请人： Shan Lu , Shixia Wang
发明人： Shan Lu , Shixia Wang
IPC分类号： A61K48/00 , C07H21/02 , C07K14/11 , C12N15/86 , A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , Y10S514/888
摘要： Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
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