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1.发明授权Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and scaffold proteins containing said peptide 有权包含呈递HIV-1 GP120 3074mAb表位的修饰环肽和含有所述肽的支架蛋白的免疫原性多肽公开(公告)号：US09534020B2
公开(公告)日：2017-01-03
申请号：US13876918
申请日：2011-09-28
申请人： Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
发明人： Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
IPC分类号： C07K14/005 , C07K7/08 , A61K39/21 , C07K14/00 , C07K14/245 , C07K14/28 , A61K39/12 , A61K39/00
CPC分类号： C07K14/001 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55555 , A61K2039/6037 , C07K7/08 , C07K14/005 , C07K14/245 , C07K14/28 , C12N2740/16034
摘要： The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
摘要翻译： 本发明涉及重组免疫原性多肽。 多肽包括插入免疫原性支架蛋白的环肽。 环多肽具有呈现HIV gp120蛋白的3074 mAb或2219/2557 mAb靶向表位的氨基酸序列，而不是HIV gp120蛋白的其他已知表位。 当用作免疫原时，多肽诱导抗体应答，其分别以与针对3074mAb-或2219 / 2557mAb靶向表位观察到的模式相似的方式中和异源HIV-1病毒。 还公开了含有免疫原性多肽的药物组合物及其制备和使用方法。
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2.发明申请IMMUNOGENIC POLYPEPTIDES HAVING AN IMMUNOGENIC SCAFFOLD PROTEIN AND A LOOP PEPTIDE, PRESENTING A 3074- OR 2219/2557- MONOCLONAL ANTIBODY-TARGETED EPITOPE, WHICH IS PRESENT IN THE HIV GP120 PROTEIN 有权具有免疫原性SCAFFOLD蛋白和环腺苷的免疫多肽具有存在于HIV GP120蛋白中的3074-或2219 / 2557-单克隆抗体靶向抗原决定簇公开(公告)号：US20130287804A1
公开(公告)日：2013-10-31
申请号：US13876918
申请日：2011-09-28
申请人： Timothy Cardozo , Xian-peng Kong , Susan Zolla-Pazner , Abraham Pinter , Chavdar Krachmarov , Shan Lu , Shixia Wang , Maxim Totrov
发明人： Timothy Cardozo , Xian-peng Kong , Susan Zolla-Pazner , Abraham Pinter , Chavdar Krachmarov , Shan Lu , Shixia Wang , Maxim Totrov
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55555 , A61K2039/6037 , C07K7/08 , C07K14/005 , C07K14/245 , C07K14/28 , C12N2740/16034
摘要： The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
摘要翻译： 本发明涉及重组免疫原性多肽。 多肽包括插入免疫原性支架蛋白的环肽。 环多肽具有呈现HIV gp120蛋白的3074 mAb或2219/2557 mAb靶向表位的氨基酸序列，而不是HIV gp120蛋白的其他已知表位。 当用作免疫原时，多肽诱导抗体应答，其分别以与针对3074mAb-或2219 / 2557mAb靶向表位观察到的模式相似的方式中和异源HIV-1病毒。 还公开了含有免疫原性多肽的药物组合物及其制备和使用方法。
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3.发明授权Immunogen comprising the HIV GP120 V3 loop in a conformation that induces broadly neutralizing antibodies 有权包含诱导广泛中和抗体的构象的HIV GP120 V3环的免疫原公开(公告)号：US08961987B2
公开(公告)日：2015-02-24
申请号：US12195318
申请日：2008-08-20
申请人： Susan Zolla-Pazner , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
发明人： Susan Zolla-Pazner , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
CPC分类号： C07K14/005 , A61K38/03 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C07K2319/35 , C07K2319/55 , C12N2740/16122 , C12N2740/16134 , Y02A50/472
摘要： Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
摘要翻译： 将HIV-1 V3环肽从病毒糖蛋白gp120插入到选定的免疫原性支架蛋白中导致重组多肽，其是有效的V3免疫原。 V3免疫原包括天然和共有的V3序列和环状和反向肽。 优选的支架蛋白是霍乱毒素亚基B及其同系物，包括密切相关的大肠杆菌肠毒素。 这样的免疫原性多肽诱导可以中和异源HIV-1亚型和菌株的V3表位特异性的广泛反应性抗gp120抗体。 公开了这些多肽，其制备方法和诱导抗gp120（V3特异性）抗体的方法）。
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4.发明申请IMMUNOGEN PRESENTING HIV GP120 V3 LOOP IN A CONFORMATION THAT INDUCES BROADLY NEUTRALIZING ANTIBODIES 有权免疫细胞提供HIV GP120 V3环路，诱导大量中和抗体公开(公告)号：US20090098144A1
公开(公告)日：2009-04-16
申请号：US12195318
申请日：2008-08-20
申请人： Susan ZOLLA-PAZNER , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
发明人： Susan ZOLLA-PAZNER , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
CPC分类号： C07K14/005 , A61K38/03 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C07K2319/35 , C07K2319/55 , C12N2740/16122 , C12N2740/16134 , Y02A50/472
摘要： Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
摘要翻译： 将HIV-1 V3环肽从病毒糖蛋白gp120插入到选定的免疫原性支架蛋白中导致重组多肽，其是有效的V3免疫原。 V3免疫原包括天然和共有的V3序列和环状和反向肽。 优选的支架蛋白是霍乱毒素亚基B及其同系物，包括密切相关的大肠杆菌肠毒素。 这样的免疫原性多肽诱导可以中和异源HIV-1亚型和菌株的V3表位特异性的广泛反应性抗gp120抗体。 公开了这些多肽，其制备方法和诱导抗gp120（V3特异性）抗体的方法）。
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公开(公告)号：US20120040932A1
公开(公告)日：2012-02-16
申请号：US13205112
申请日：2011-08-08
申请人： Gavin Hirst , Raja Reddy , Scott Hecker , Maxim Totrov , David C. Griffith , Olga Rodny , Michael N. Dudley , Serge Boyer
发明人： Gavin Hirst , Raja Reddy , Scott Hecker , Maxim Totrov , David C. Griffith , Olga Rodny , Michael N. Dudley , Serge Boyer
CPC分类号： A61K31/69 , A61K9/0019 , A61K9/0053 , A61K31/407 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/546 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及1种环状硼酸酯衍生物及其作为治疗剂的用途。
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公开(公告)号：US09012491B2
公开(公告)日：2015-04-21
申请号：US14241412
申请日：2012-08-30
申请人： Raja K. Reddy , Serge Henri Boyer , Maxim Totrov , Scott Hecker
发明人： Raja K. Reddy , Serge Henri Boyer , Maxim Totrov , Scott Hecker
IPC分类号： A61K31/381 , C07D333/10 , A61K31/69 , A61K45/06 , A61K31/427 , A61K31/43 , A61K31/546 , C07F5/02 , A61K31/426 , A61K47/26 , A61K9/08 , A61K9/00
CPC分类号： A61K31/69 , A61K9/0014 , A61K9/0019 , A61K9/08 , A61K31/426 , A61K31/427 , A61K31/43 , A61K31/546 , A61K45/06 , A61K47/26 , C07F5/025 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及环状硼酸酯化合物及其作为治疗剂的用途。
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公开(公告)号：US20140206648A1
公开(公告)日：2014-07-24
申请号：US14241412
申请日：2012-08-30
申请人： Raja K. Reddy , Serge Henri Boyer , Maxim Totrov , Scott Hecker
发明人： Raja K. Reddy , Serge Henri Boyer , Maxim Totrov , Scott Hecker
IPC分类号： C07F5/02 , A61K31/426 , A61K45/06 , A61K31/69
CPC分类号： A61K31/69 , A61K9/0014 , A61K9/0019 , A61K9/08 , A61K31/426 , A61K31/427 , A61K31/43 , A61K31/546 , A61K45/06 , A61K47/26 , C07F5/025 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及环状硼酸酯化合物及其作为治疗剂的用途。
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8.发明授权Hydrazide compounds as thyroid hormone receptor modulators and uses thereof 有权酰肼化合物作为甲状腺激素受体调节剂及其用途公开(公告)号：US08394811B2
公开(公告)日：2013-03-12
申请号：US12450922
申请日：2008-04-18
申请人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
发明人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
IPC分类号： A61K31/438 , A61K31/4418 , A61P5/16 , C07D211/70 , C07D471/10
CPC分类号： C07D471/10 , C07D211/70
摘要： A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
摘要翻译： 公开了鉴定调节甲状腺激素活性的化合物的方法，以及这些化合物及其组合物用于此目的的用途。 化合物可以选自：化合物可以制备为药物组合物，并且可以用于预防和治疗与异常甲状腺激素活性如甲状腺功能亢进和甲状腺毒症有因果关系的病症。
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9.发明申请HYDRAZIDE COMPOUNDS AS THYROID HORMONE RECEPTOR MODULATORS AND USES THEREOF 有权作为甲状腺激素受体调节剂的氢化物化合物及其用途公开(公告)号：US20100286182A1
公开(公告)日：2010-11-11
申请号：US12450922
申请日：2008-04-18
申请人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
发明人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
IPC分类号： A61K31/438 , A61K31/4418 , C07D471/10 , C07D211/70 , A61P5/16
CPC分类号： C07D471/10 , C07D211/70
摘要： A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
摘要翻译： 公开了鉴定调节甲状腺激素活性的化合物的方法，以及这些化合物及其组合物用于此目的的用途。 化合物可以选自：化合物可以制备为药物组合物，并且可以用于预防和治疗与异常甲状腺激素活性如甲状腺功能亢进和甲状腺毒症有因果关系的病症。
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公开(公告)号：US08680136B2
公开(公告)日：2014-03-25
申请号：US13205112
申请日：2011-08-08
申请人： Gavin Hirst , Raja Reddy , Scott Hecker , Maxim Totrov , David C. Griffith , Olga Rodny , Michael N. Dudley , Serge Boyer
发明人： Gavin Hirst , Raja Reddy , Scott Hecker , Maxim Totrov , David C. Griffith , Olga Rodny , Michael N. Dudley , Serge Boyer
IPC分类号： A61K31/44 , A61K31/381 , C07D213/02 , C07D333/10
CPC分类号： A61K31/69 , A61K9/0019 , A61K9/0053 , A61K31/407 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/546 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及1种环状硼酸酯衍生物及其作为治疗剂的用途。
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