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    CONDENSATION REACTION CURABLE SILICONE ORGANIC BLOCK COPOLYMER COMPOSITION CONTAINING A PHOSPHONATE CATALYST AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITION
    2.
    发明申请
    CONDENSATION REACTION CURABLE SILICONE ORGANIC BLOCK COPOLYMER COMPOSITION CONTAINING A PHOSPHONATE CATALYST AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITION 审中-公开
    含有磷酸酯催化剂的凝结反应可固化有机硅嵌段共聚物组合物及其组合物的制备和使用方法

    公开(公告)号：US20140024774A1

    公开(公告)日：2014-01-23

    申请号：US14007734

    申请日：2012-03-12

    申请人： Simon Cook ,  Geraldine Durand ,  Thomas Easton ,  Sarah O'Hare ,  Avril Surgenor ,  Richard Taylor

    发明人： Simon Cook ,  Geraldine Durand ,  Thomas Easton ,  Sarah O'Hare ,  Avril Surgenor ,  Richard Taylor

    IPC分类号： C08G77/46 ,  C09D183/12 ,  C08K5/5419

    CPC分类号： C08K5/5419 ,  C08G77/12 ,  C08G77/18 ,  C08G77/20 ,  C08G77/46 ,  C08K5/0025 ,  C08K5/524 ,  C08K5/5317 ,  C08K5/5425 ,  C08L83/12 ,  C09D183/12

    摘要： A condensation reaction curable composition comprises a new catalyst, Dow Corning® 4-6085, and a polyorganosiloxane polyoxyalkylene block copolymer having one or more polyorganosiloxane blocks and one or more polyoxyalkylene blocks linked to each other via divalent radicals which comprises at least two silicon-bonded alkoxy groups, preferably of the form PS-(A-PO)m-(A-PS)n, wherein PO is a polyoxyalkylene block, PS represents a polyorganosiloxane block, A is a divalent radical, subscripts m and n have independently a value of at least 1, comprising at least one alkoxy-substituted siloxane unit of the formula (R′)q(OR)—SiO3-q/2, wherein R represents an alkyl group having 1 to 4 carbon atoms and each R′ represents an alkyl group having 1 to 6 carbon atoms, a phenyl group, or an alkoxy group of the formula —OR and subscript q has a value of 0, 1 or 2, provided at least two silicon-bonded groups OR are present in the block copolymer.

    摘要翻译： 缩合反应固化的组合物包含新的催化剂，Dow Corning 4-6085和具有一个或多个聚有机硅氧烷嵌段和一个或多个聚氧化烯嵌段的聚有机硅氧烷聚氧化烯嵌段共聚物，该聚有机硅氧烷嵌段通过二价基团彼此连接，该二价基团包含至少两个硅键合 烷氧基，优选形式为PS-（A-PO）m-（A-PS）n，其中PO是聚氧化烯嵌段，PS表示聚有机硅氧烷嵌段，A是二价基团，下标m和n独立地为 至少一个，包含至少一个式（R'）q（OR）-SiO 3-q / 2的烷氧基取代的硅氧烷单元，其中R表示具有1至4个碳原子的烷基，并且每个R'表示 具有1至6个碳原子的烷基，苯基或式-OR和下标q的烷氧基具有0,1或2的值，只要至少两个硅键合基团或存在于嵌段共聚物中 。

    Morpholine dopamine agonists
    4.
    发明授权
    Morpholine dopamine agonists 失效
    吗啉多巴胺激动剂

    公开(公告)号：US07576081B2

    公开(公告)日：2009-08-18

    申请号：US11425030

    申请日：2006-06-19

    申请人： Charlotte Moira Norfor Allerton ,  Andrew Douglas Baxter ,  Andrew Simon Cook ,  David Hepworth ,  Stephen Kwok-Fung Wong

    发明人： Charlotte Moira Norfor Allerton ,  Andrew Douglas Baxter ,  Andrew Simon Cook ,  David Hepworth ,  Stephen Kwok-Fung Wong

    IPC分类号： A61K31/5377 ,  C07D413/04

    CPC分类号： C07D265/30 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.

    摘要翻译： 本发明提供式（I），（Ia）和（Ib）化合物，其中A选自CX和N，B选自CY和N，R 1选自H和（C 1 -C 6）烷基， R2选自H和（C1-C6）烷基，X选自H，HO，C（O）NH2，NH2Y选自H，HO，NH2，Br，Cl和FZ选自H，HOF ，CONH2和CN; 其药学上可接受的盐，溶剂合物和前药; 条件是：对于式（I），（Ia）或（Ib）的化合物，当A是CX时，B是CY，R 1是H或（C 1 -C 6）烷基，R 2是H或（C 1 -C 6） ）烷基，X，Y和Z中的至少一个必须是OH; 对于式（I）化合物，当A为C-X且B为C-Y时，Y为H，Z为H，R 1为H且R 2为H，则X不能为OH; 这些化合物可用作药物。

    New Amino Derivatives and Their Use as Pharmaceuticals
    7.
    发明申请
    New Amino Derivatives and Their Use as Pharmaceuticals 审中-公开
    新型氨基衍生物及其作为药物的用途

    公开(公告)号：US20090005354A1

    公开(公告)日：2009-01-01

    申请号：US12208148

    申请日：2008-09-10

    申请人： Charlotte Moira Norfor Allerton ,  Andrew Simon Cook ,  David Hepworth ,  Duncan Charles Miller

    发明人： Charlotte Moira Norfor Allerton ,  Andrew Simon Cook ,  David Hepworth ,  Duncan Charles Miller

    IPC分类号： A61K31/397 ,  C07D413/02 ,  A61K31/5377 ,  A61P25/00 ,  A61P15/00 ,  C07D401/02

    CPC分类号： C07D413/04 ,  C07D401/04

    摘要： The present invention provides for compounds of formula (I): which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供了式（I）化合物：其是一类多巴胺激动剂，更特别的是在D2上对D3具有选择性的一类激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤起障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。