公开(公告)号：US07736863B2

公开(公告)日：2010-06-15

申请号：US11613866

申请日：2006-12-20

Applicant: Stephen Poole ,  Mehul Patel

Inventor： Stephen Poole ,  Mehul Patel

IPC: G01N33/567 ,  C12M1/34

CPC classification number: G01N33/6869 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5091 ,  G01N33/6863 ,  G01N2333/5412 ,  G01N2800/7095

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

Abstract translation: 描述了改进的单核细胞活化试验，其更能够检测医疗产品中的非内毒素热原，其中将样品与包含至少一个包含聚丙烯的表面的测定系统中的含单核细胞的试剂一起温育。 本发明还涉及用于这些测试的测定系统，其包括至少一个微量滴定孔，其具有至少一个包含聚丙烯的内表面，并且具有使含单核细胞的试剂在孔中浓缩以提供更大的细胞与细胞接触的形状。 本发明还涉及可用于测试样品中非内毒素热原的存在的诊断试剂盒。

公开(公告)号：US20070191307A1

公开(公告)日：2007-08-16

申请号：US11538766

申请日：2006-10-04

Applicant: Mark Bartlett ,  Angela Mastaloudis ,  Carsten Smidt ,  Stephen Poole

Inventor： Mark Bartlett ,  Angela Mastaloudis ,  Carsten Smidt ,  Stephen Poole

IPC: A61K31/702

CPC classification number: A61K47/48969 ,  A23L33/115 ,  A23L33/12 ,  A23L33/155 ,  A23V2002/00 ,  A61K9/4866 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61K31/355 ,  A61K31/724 ,  A61K47/40 ,  A61K47/44 ,  A61K47/6951 ,  A23V2200/224 ,  A23V2250/5112 ,  A23V2250/211 ,  A23V2250/1882 ,  A23V2250/702 ,  A23V2250/712

Abstract: Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.

Abstract translation: 制备纳米营养配方以增强营养剂吸收的方法。 这些方法包括环糊精与类胡萝卜素的络合，并将复合物掺入营养补充剂中，而无需中间收集，分离和干燥步骤。

公开(公告)号：US06790832B2

公开(公告)日：2004-09-14

申请号：US10127572

申请日：2002-04-23

Applicant: Jürgen Römisch ,  Gerhard Dickneite ,  Peter Gronski ,  Bernhard Vohwinkel ,  Harald Stauss ,  Elaine Gray ,  Pauline Sxouter ,  Stephen Poole

Inventor： Jürgen Römisch ,  Gerhard Dickneite ,  Peter Gronski ,  Bernhard Vohwinkel ,  Harald Stauss ,  Elaine Gray ,  Pauline Sxouter ,  Stephen Poole

IPC: A61K3800

CPC classification number: A61K38/57 ,  Y10S514/825

Abstract: A pharmaceutical preparation is described while is useful for the treatment of inflammatory processes being accompanied by an increased distribution of cytokines and/or tissue factor in the human body, which preparation contains Antithrombin III as active ingredient.

Abstract translation: 描述了药物制剂，同时可用于治疗炎性过程，伴随着人体中细胞因子和/或组织因子的分布增加，该制剂含有抗凝血酶III作为活性成分。

公开(公告)号：US06399572B1

公开(公告)日：2002-06-04

申请号：US09492790

申请日：2000-01-28

Applicant: Jürgen Römisch ,  Gerhard Dickneite ,  Peter Gronski ,  Bernhard Vohwinkel ,  Harald Stauss ,  Elaine Gray ,  Pauline Sxouter ,  Stephen Poole

Inventor： Jürgen Römisch ,  Gerhard Dickneite ,  Peter Gronski ,  Bernhard Vohwinkel ,  Harald Stauss ,  Elaine Gray ,  Pauline Sxouter ,  Stephen Poole

IPC: A61K3800

CPC classification number: A61K38/57 ,  Y10S514/825

Abstract: A pharmaceutical preparation is described while is useful for the treatment of inflammatory processes being accompanied by an increased distribution of cytokines and/or tissue factor in the human body, which preparation contains Antithrombin III as active ingredient.

Abstract translation: 描述了药物制剂，同时可用于治疗炎性过程，伴随着人体中细胞因子和/或组织因子的分布增加，该制剂含有抗凝血酶III作为活性成分。

公开(公告)号：US4572837A

公开(公告)日：1986-02-25

申请号：US625646

申请日：1984-06-28

Applicant: Stephen Poole ,  Stuart I. West ,  Clifford L. Walters

Inventor： Stephen Poole ,  Stuart I. West ,  Clifford L. Walters

IPC: A21D13/00 ,  A21D13/08 ,  A23G3/00 ,  A23G3/44 ,  A23G3/52 ,  A23J3/00 ,  A23L1/00 ,  A23L1/04 ,  A23L1/24

CPC classification number: A21D13/0093 ,  A23G3/44 ,  A23G3/52 ,  A23J3/00 ,  A23P30/40 ,  Y10S426/804

Abstract: An aqueous dispersion containing both acidic and basic proteins and gives better foaming, gelling and emulsion properties than solutions of acidic proteins alone. The basic protein may be made by modifying an acidic protein. Improved aerated products such as meringues and nougat may be made using the solutions.

Abstract translation: 含有酸性和碱性蛋白质的水分散体，并且比单独的酸性蛋白质溶液具有更好的起泡，胶凝和乳液性能。 碱性蛋白质可以通过改变酸性蛋白质来制备。 改进的充气产品，如蛋白酥皮和牛轧糖，可以使用这些解决方案。

公开(公告)号：US772791A

公开(公告)日：1904-10-18

申请号：US1902099358

申请日：1902-03-21

Applicant: STEPHEN POOLE SANDERS

Inventor： DOW EDGAR L

CPC classification number: B01F3/04539 ,  Y02B30/545 ,  Y10S261/37

公开(公告)号：US20100203551A1

公开(公告)日：2010-08-12

申请号：US12767537

申请日：2010-04-26

Applicant: Stephen Poole ,  Mehul Patel

Inventor： Stephen Poole ,  Mehul Patel

IPC: G01N33/53

CPC classification number: G01N33/6869 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5091 ,  G01N33/6863 ,  G01N2333/5412 ,  G01N2800/7095

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

公开(公告)号：US07464081B2

公开(公告)日：2008-12-09

申请号：US10823370

申请日：2004-04-12

Applicant: James Michael McKinley ,  Timothy Joseph Kane ,  Stephen Poole ,  Tammy Nguyen ,  Wahome Muchiri

Inventor： James Michael McKinley ,  Timothy Joseph Kane ,  Stephen Poole ,  Tammy Nguyen ,  Wahome Muchiri

IPC: G06F17/30

CPC classification number: H04L67/02 ,  H04L69/08 ,  Y10S707/99934

Abstract: A method and system of translating data from a first format into one or more translated formats includes initiating a translation request on one of plurality of client systems. The translation request includes source data to be translated from the first format into desired translated formats and configuration data defining each type of translation to be performed on the source data. The translation request is communicated to a server system and is processed on the server system to determine from the configuration data the type of each data translation to be performed on the data. The data is provided to an appropriate translation service on the server system and is translated to the appropriate translated format via the corresponding translation service. A return translation request is communicated to the client system, the return translation request including the data in each translated format.

Abstract translation: 将数据从第一格式转换为一个或多个翻译格式的方法和系统包括在多个客户端系统之一上发起翻译请求。 翻译请求包括要从第一格式转换为期望的翻译格式的源数据和定义要对源数据执行的每种类型的翻译的配置数据。 将翻译请求传送到服务器系统，并在服务器系统上进行处理，从配置数据中确定要对数据执行的每个数据转换的类型。 将数据提供给服务器系统上的适当的翻译服务，并通过相应的翻译服务转换为适当的翻译格式。 返回翻译请求被传送到客户端系统，返回翻译请求包括每种转换格式的数据。

公开(公告)号：US20060101414A1

公开(公告)日：2006-05-11

申请号：US11247790

申请日：2005-10-11

Applicant: Stephen Poole

Inventor： Stephen Poole

IPC: G06F9/44 ,  G06F11/00

CPC classification number: G06F11/3684 ,  G06F9/44589

Abstract: Generates self-checking software by providing characteristics of a specification; traversing points in state space defined by the characteristics to generate stand-alone test code; determining if the generated code is deterministic; and forming expected results of the test code into a standalone, self-checking body of test cases. The expected results may be merged back into randomly generated test cases to form the standalone, self-checking body of test cases.

Abstract translation: 通过提供规格的特征生成自检软件; 通过由特征定义的状态空间中的遍历点来生成独立测试代码; 确定所生成的代码是否是确定性的; 并将测试代码的预期结果形成为独立的自检单元的测试用例。 预期的结果可能会被并入随机生成的测试用例中，形成独立的自检实体。

公开(公告)号：US08058021B2

公开(公告)日：2011-11-15

申请号：US12767514

申请日：2010-04-26

Applicant: Stephen Poole ,  Mehul Patel

Inventor： Stephen Poole ,  Mehul Patel

IPC: G01N33/00 ,  C12M3/00 ,  C12M1/34

CPC classification number: G01N33/6869 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5091 ,  G01N33/6863 ,  G01N2333/5412 ,  G01N2800/7095

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.