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1.发明申请LEAFHOPPER ECDYSONE RECEPTOR NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF 有权LEAFHOPPER ECDYSONE受体核酸，多糖及其用途公开(公告)号：US20080280321A9
公开(公告)日：2008-11-13
申请号：US10490971
申请日：2002-02-20
Applicant: Subba Palli
Inventor： Subba Palli
IPC: A01N37/18 , C07H21/04 , C07K14/705 , C12N5/06
CPC classification number: C07K14/43563
Abstract: The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene eypression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate leafhopper ecdysone receptor activity.
Abstract translation: 本发明涉及一种新型的分离的叶蝉蜕皮激素受体多肽。 本发明还涉及编码叶蝉蜕皮激素受体多肽的分离的核酸，包含它们的载体及其用途，特别是用于调节基于蜕皮激素受体的基因表达调节系统中的基因表达的方法以及用于鉴定调节的分子的方法 叶蝉蜕皮激素受体活性。
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公开(公告)号：US20070161086A1
公开(公告)日：2007-07-12
申请号：US11677968
申请日：2007-02-22
Applicant: Subba Palli , Marianna Kapitskaya , Dean Cress
Inventor： Subba Palli , Marianna Kapitskaya , Dean Cress
IPC: C12P21/06 , C12N15/09 , C07K14/705 , C07H21/04
CPC classification number: C12N15/63 , C07K2319/71 , C07K2319/715 , C07K2319/80 , C12N15/1055 , C12N15/85 , C12N2510/00 , C12N2830/002 , C12N2830/15
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及一种新的诱导型基因表达系统和调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质和抗体的大规模生产，基于细胞的高通量筛选测定，功能基因组学和调节 的转基因植物和动物的性状。
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3.发明申请TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX 审中-公开用于通过ECDYSONE受体复合物调节外源基因表达的四氢喹啉公开(公告)号：US20050228016A1
公开(公告)日：2005-10-13
申请号：US10460820
申请日：2003-06-12
Applicant: Enrique Michelotti , Colin Tice , Subba Palli , Christine Thompson , Tarlochan Dhadialla
Inventor： Enrique Michelotti , Colin Tice , Subba Palli , Christine Thompson , Tarlochan Dhadialla
IPC: A61K31/47 , C07D215/42 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , A61K31/4709 , C07D215/38 , C07D45/02 , C07D49/02
CPC classification number: C07D215/44 , A61K31/47 , C07D215/42 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06
Abstract: This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of 4-tetrahydroquinolines.
Abstract translation: 本发明涉及一种调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合域; 配体结合域; 反式激活域 并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。 配体包括一类4-四氢喹啉。
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公开(公告)号：US20080268499A9
公开(公告)日：2008-10-30
申请号：US10490976
申请日：2002-02-20
Applicant: Jianzhong Zhang , Dean Cress , Subba Palli , Tarlochart Dhadialla
Inventor： Jianzhong Zhang , Dean Cress , Subba Palli , Tarlochart Dhadialla
CPC classification number: G01N33/566 , C07K14/43577 , G01N2333/723
Abstract: The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.
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5.发明申请NOVEL SUBSTITUTION MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM 有权新型替代突变体受体及其在基于受体基因的诱导基因表达系统中的应用公开(公告)号：US20070300313A1
公开(公告)日：2007-12-27
申请号：US11841529
申请日：2007-08-20
Applicant: Subba Palli , Mohan Kumar , Dean Cress , Ted Fujimoto
Inventor： Subba Palli , Mohan Kumar , Dean Cress , Ted Fujimoto
CPC classification number: C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于H核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于基因治疗，大规模生产 蛋白质和抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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Patent Agency Ranking
公开(公告)号：US20080115237A1
公开(公告)日：2008-05-15
申请号：US11841495
申请日：2007-08-20
Applicant: Subba Palli , Marianna Kapitskaya , Dean Cress
Inventor： Subba Palli , Marianna Kapitskaya , Dean Cress
IPC: A01K67/027 , A01H5/00 , C07H21/00 , C07K14/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/63 , C12N5/04 , C12N5/06 , C12N5/08 , C12N5/10
CPC classification number: C12N15/63 , C07K2319/71 , C07K2319/715 , C07K2319/80 , C12N15/1055 , C12N15/85 , C12N2510/00 , C12N2830/002 , C12N2830/15
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及一种新的诱导型基因表达系统和调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质和抗体的大规模生产，基于细胞的高通量筛选测定，功能基因组学和调节 的转基因植物和动物的性状。
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7.发明申请公开(公告)号：US20080051344A1
公开(公告)日：2008-02-28
申请号：US11840659
申请日：2007-08-17
Applicant: Subba Palli , Tarlochan Dhadialla , Jianzhong Zhang , Dean Cress
Inventor： Subba Palli , Tarlochan Dhadialla , Jianzhong Zhang , Dean Cress
IPC: A61K38/16 , A61K31/7052 , A61P43/00 , C07H21/00 , C07K14/435 , C07K16/22 , C12N1/15 , C12N1/21 , C12N15/63 , C12N5/10 , C12Q1/02
CPC classification number: G01N33/566 , C07K14/43577 , G01N2333/723
Abstract: The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.
Abstract translation: 本发明涉及一种新型的孤立的粉虱蜕皮激素受体多肽。 本发明还涉及编码粉虱蜕皮激素受体多肽的分离的核酸，包含它们的载体及其用途，特别是用于调节基于蜕皮激素受体的基因表达调节系统中的基因表达的方法和用于鉴定调节的分子的方法 粉虱蜕皮激素受体活性。
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8.发明申请Mutant receptors and their use in a nuclear receptor-based inducible gene expression system 有权突变体受体及其在基于核受体的诱导型基因表达系统中的应用公开(公告)号：US20050266457A1
公开(公告)日：2005-12-01
申请号：US11118855
申请日：2005-04-28
Applicant: Subba Palli , Mohan Kumar
Inventor： Subba Palli , Mohan Kumar
IPC: A01K67/00 , A61K31/16 , A61K31/47 , C07D215/16 , C07H21/04 , C07K14/435 , C07K14/705 , C12N15/62 , C12P21/06 , C12Q1/68
CPC classification number: C12N15/85 , A61K31/16 , A61K31/47 , C07D215/44 , C07H21/04 , C07K14/43536 , C12N15/62 , C12N15/63 , C12N15/635 , Y10S530/858
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，大规模生产蛋白质和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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9.发明申请LEAFHOPPER ECDYSONE RECEPTOR NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF 有权LEAFHOPPER ECDYSONE受体核酸，多糖及其用途公开(公告)号：US20080064097A1
公开(公告)日：2008-03-13
申请号：US11837834
申请日：2007-08-13
Applicant: Subba Palli
Inventor： Subba Palli
CPC classification number: C07K14/43563
Abstract: The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate leafhopper ecdysone receptor activity.
Abstract translation: 本发明涉及一种新型分离的叶蝉蜕皮激素受体多肽。 本发明还涉及编码叶蝉蜕皮激素受体多肽的分离的核酸，包含它们的载体及其用途，特别是用于调节基于蜕皮激素受体的基因表达调节系统中的基因表达的方法以及用于鉴定调节的分子的方法 叶蝉蜕皮激素受体活性。
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10.发明申请Novel substitution mutant receptors and their use in an nuclear receptor-based inducible gene expression system 有权新型取代突变体受体及其在基于核受体的诱导型基因表达系统中的应用公开(公告)号：US20060100416A1
公开(公告)日：2006-05-11
申请号：US10468193
申请日：2002-02-20
Applicant: Subba Palli , Mohan Kumar , Dean Cress , Ted Fujimoto
Inventor： Subba Palli , Mohan Kumar , Dean Cress , Ted Fujimoto
IPC: A01K67/00 , C07H21/04 , C12P21/06 , C07K14/715
CPC classification number: C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于H核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于基因治疗，大规模生产 蛋白质和抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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