公开(公告)号：US08524238B2

公开(公告)日：2013-09-03

申请号：US13436411

申请日：2012-03-30

Applicant: Dong Fang ,  Paul Moore ,  Steve Ruben ,  Sudeepta Aggarwal

Inventor： Dong Fang ,  Paul Moore ,  Steve Ruben ,  Sudeepta Aggarwal

IPC: A61K39/395 ,  A61K39/00

CPC classification number: C07K16/249 ,  A61K39/39533 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/57 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/10

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供了使用癌症相关靶标（“CAT”）评估，治疗和预防疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US08168586B1

公开(公告)日：2012-05-01

申请号：US12275779

申请日：2008-11-21

Applicant: Dong Fang ,  Paul Moore ,  Steve Ruben ,  Sudeepta Aggarwal

Inventor： Dong Fang ,  Paul Moore ,  Steve Ruben ,  Sudeepta Aggarwal

IPC: A61K38/00 ,  G01N33/574 ,  C12Q1/68 ,  A61K51/10 ,  A61K39/00

CPC classification number: C07K16/249 ,  A61K39/39533 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/57 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/10

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供了使用癌症相关靶标（“CAT”）评估，治疗和预防疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US08486392B2

公开(公告)日：2013-07-16

申请号：US12901254

申请日：2010-10-08

Applicant: Steve Ruben ,  Paul Moore ,  Tao He ,  Candy N. Lee ,  Karen Van Orden

Inventor： Steve Ruben ,  Paul Moore ,  Tao He ,  Candy N. Lee ,  Karen Van Orden

IPC: A61K39/395

CPC classification number: C07K16/3076 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70546 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/2839 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N9/18 ,  C12N9/6424 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y301/01 ,  C12Y304/21 ,  C12Y304/21109 ,  G01N33/57488 ,  G01N33/57492

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US07776555B1

公开(公告)日：2010-08-17

申请号：US11822094

申请日：2007-07-02

Applicant: Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

Inventor： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

IPC: G01N33/53

CPC classification number: G01N33/57419

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US07521195B1

公开(公告)日：2009-04-21

申请号：US11490329

申请日：2006-07-21

Applicant: Elizabeth Joseloff ,  Aiqun Li ,  Tao He ,  Steve Ruben

Inventor： Elizabeth Joseloff ,  Aiqun Li ,  Tao He ,  Steve Ruben

IPC: G01N33/53

CPC classification number: G01N33/57423 ,  G01N2500/04 ,  Y10T436/143333

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.

Abstract translation: 本发明提供了诊断和检测与肺相关疾病的方法。 本发明提供在肺部疾病（LCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合LCAT。 本发明提供LCAT作为调节LCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肺相关疾病的方法。

公开(公告)号：US07611703B1

公开(公告)日：2009-11-03

申请号：US11717149

申请日：2007-03-13

Applicant: Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

Inventor： Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

IPC: A61K39/395

CPC classification number: C07K14/4748 ,  A61K2039/505 ,  C07K16/3038

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

Abstract translation: 本发明提供了诊断和检测与肾相关的疾病的方法。 本发明提供在肾脏疾病（KCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合KCAT。 本发明提供KCAT作为调节KCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肾相关的疾病的方法。

公开(公告)号：US20090123461A1

公开(公告)日：2009-05-14

申请号：US12255340

申请日：2008-10-21

Applicant: William Fitzhugh ,  Steve Ruben ,  Vaibhav Narayan ,  Charles E. Birse

Inventor： William Fitzhugh ,  Steve Ruben ,  Vaibhav Narayan ,  Charles E. Birse

IPC: A61K39/395 ,  C07K14/00 ,  C07K16/00 ,  C07H21/00 ,  A01K67/027 ,  C12N15/63 ,  A61P35/00 ,  C12N5/10 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6886 ,  A01K2217/05 ,  C07K14/705 ,  C12Q2600/136 ,  G01N2333/70596

Abstract: The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.

Abstract translation: 本发明提供一种诊断和检测癌症的方法。 本发明提供了一种或多种在癌症（podocalyxin）中差异表达的蛋白质或其片段，肽或核酸分子以及结合足芽荚膜球蛋白的抗体。 本发明提供了足孢菌素作为调节球蛋白活性的筛选剂的靶标。 此外，本发明提供了用于治疗与足荚体蛋白表达相关的疾病的方法。

公开(公告)号：US20070031419A1

公开(公告)日：2007-02-08

申请号：US11476141

申请日：2006-06-28

Applicant: Bruno Domon ,  Charles Birse ,  Candy Lee ,  Steve Ruben

Inventor： Bruno Domon ,  Charles Birse ,  Candy Lee ,  Steve Ruben

IPC: A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/10 ,  G01N2800/52

Abstract: Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro.

Abstract translation: 与健康细胞相比，用于检测和治疗与疾病细胞中CDCP1的差异表达相关的疾病，特别是癌症的方法和组合物。 还提供了CDCP1的拮抗剂或激动剂，以及筛选在体内或体外调节CDCP1水平或活性的药剂的方法。

公开(公告)号：US20050118679A1

公开(公告)日：2005-06-02

申请号：US10979092

申请日：2004-11-02

Applicant: Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

Inventor： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C12N1/21 ,  C12N9/00 ,  C12N9/64 ,  C12N15/57 ,  C07H21/04 ,  A61K39/395 ,  C07K16/40

CPC classification number: C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

Abstract translation: 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

公开(公告)号：US08334106B2

公开(公告)日：2012-12-18

申请号：US13339833

申请日：2011-12-29

Applicant: Steve Ruben ,  Candy N. Lee ,  Bruno Domon

Inventor： Steve Ruben ,  Candy N. Lee ,  Bruno Domon

IPC: G01N33/574

CPC classification number: G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.